Publications:

2010  2009  2008  2007  2006  2005  2004  2003  2002  2001 
2000  1999  1998  1997  1996  1995  1994  1993  1992  1991 
1990  1989  1988  1987  1986  1985  1984 


2010 219.  Hessel,S., John,A., Seidel,A., Glatt,H., and Lampen, A. Effects of quercetin on the detoxification of the food contaminant benzo[a]pyrene in the human intestinal Caco-2 cell model, in “Risk assessment of phytochemicals in food - novel approaches” (G. Eisenbrand ed.), (2010) accepted.

 

2009   218.  Hessel, S., John, A., Seidel, A., and Lampen, A. (2009) All-trans retinoic acid induces breast cancer resistance protein expression in Caco-2 cells and enhances the transport of benzo[a]pyrene-3-sulfate, Toxicol. Lett. 189 (Suppl.), in press.

 


  217. Eder, C., Frankenberger, M., Stanzel, F., Seidel, A., Schramm, K.-W., Ziegler-Heitbrock, L., and Hofer Th.P.J. Ultrafine Carbon particles down-regulate CYP1B1 expression in human monocytes. Part Fibre Toxicol 6, 27 (2009) – open access http://www.particleandfibretoxicology.com/content/6/1/27.

 


  216.  Monien, B.H., Müller, C., Bakhiya, N., Donath, C., Frank, H., Seidel, A., and Glatt, H.R. Probenecid, an inhibitor of transmembrane organic anion transporters, alters tissue distribution of DNA adducts in 1-hydroxymethylpyrene-treated rats. Toxicology. 262, 80-85 (2009).

 


  215.  Bakhiya, N., Monien, B., Frank, H., Seidel, A., and Glatt, H.R. Renal organic anion transporters OAT1 and OAT3 mediate the cellular accumulation of 5-sulfooxy-methylfurfural, a reactive, nephrotoxic metabolite of the Maillard product 5-hydroxy-methylfurfural. Biochem. Pharmacol. 78, 414-419 (2009).

 


  214.  Marczynski, B., Pesch, B., Wilhelm, M., Rossbach, B., Preuss, R., Hahn, J.-U., Rabstein, S., Raulf-Heimsoth, M., Seidel, A., Rihs, H.-P., Adams, A., Scherenberg, M., Erkes, A., Engelhardt, B., Straif, K., Käfferlein, H. U., Angerer, J., and Brüning, T. Occupational Exposure to Polycyclic Aromatic Hydrocarbons and DNA Damage by Industry – A Nationwide Study in Germany. Arch. Tox. 83, 947-957 (2009).

 


  213.  Monien, B.H., Frank, H., Seidel, A., and Glatt, H. Conversion of the common food constituent, 5-hydroxymethylfurfural into a mutagenic and carcinogenic sulfuric acid ester in the mouse in vivo. Chem Res. Toxicol. 22, 1123-1128 (2009).

 


  212.  Kuhn, K., Nowak, B., Behnke, A., Seidel, A., and Lampen, A. Combined chemical and effect-directed analysis of Polycyclic Aromatic Hydrocarbons in smoked pork. Food Addit Contam. 26, 1104-1112 (2009).

 


  211.  Schreck, I., Chudziak, D., Schneider, S., Seidel, A., Platt, K.-L., Oesch, F., and Weiss, C. Influence of aryl hydrocarbon-(Ah) receptor and genotoxins on DNA repair gene expression and cell survival of mouse hepatoma cells. Toxicology 259, 91-96 (2009).

 


  210.  Kabler, S.L., Seidel, A., Jacob, J., Doehmer, J., Morrow, C.S., and Townsend, A.J. Protection by human glutathione S-transferase P1 against cytotoxicity by benzo[a]pyrene or benzo[a]pyrene-7,8-dihydrodiol enantiomers in bi-transgenic cell lines that co-express rat or human cytochrome P4501A1. Chem.-Biol. Interact. 179, 240-246 (2009).

 

2008   209.  Yagi, H., Frank, H., Seidel, A., and Jerina, D.M. Revised assignment of absolute configuration of the cis- and trans-N6-deoxyadenosine adducts at C14 of (±)-11β,12α-dihydroxy-13α,14α-epoxy-11,12,13,14-tetrahydrodibenzo[a,l]pyrene by stereoselective synthesis. Chem. Res. Toxicol. 21, 2379-2392. (2008).

 


  208.  Monien, B.H., Muller, C., Engst, W., Frank, H., Seidel, A. and Glatt, H. Time course of hepatic 1-methylpyrene DNA adducts in rats determined by isotope dilution LC-MS/MS and 32P-postlabeling. Chem. Res. Toxicol., 21, 2017-2025 (2008).

 


  207.  Lagerqvist, A., Håkansson, D., Prochazka, G., Lundin, C., Dreij, K., Segerbäck, D., Jernström, B., Törnqvist, M., Seidel, A., Erixon, K., and Jenssen, D. Both replication bypass fidelity and repair efficiency influence the yield of mutations per target dose in intact mammalian cells induced by benzo[a]pyrene-diol-epoxide and dibenzo[a,l]pyrene-diol-epoxide. DNA Repair. 7, 1202-1212 (2008).

 


  206.  Glatt, H., Rost, K., Frank, H., Seidel, A., and Kollock, R. Detoxification of promutagenic aldehydes derived from methylpyrenes by human aldehyde dehydrogenases ALDH2 and ALDH3A1. Arch. Biochem. Biophys., 477, 196-205 (2008).

 


  205.  Kuhn, K., Nowak, N., Klein, G., Behnke, A., Seidel, A., and Lampen, A. Determination of polycyclic aromatic hydrocarbons in smoked pork by effect directed bioassay with confirmation by chemical analysis. J. Food Protect. 71, 993-999 (2008).

 


  204.  Seidel, A., Spickenheuer, A., Straif, K., Rihs, H.-P., Marczynski, B., Scherenberg, M., Dettbarn, G., Angerer, J., Wilhelm, M., Brüning, T., Jacob, J., and Pesch, B. New biomarkers of occupational exposure to polycyclic aromatic hydrocarbons. J. Toxicol. Environ. Health A 71, 1–12 (2008).

 


  203.  Kollock, R., Frank, H., Seidel, A., Meinl, W. and Glatt, H. Oxidation of alcohols and reduction of aldehydes derived from methyl- and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases. Toxicology, 245, 65-75 (2008).

 


  202.  Pääjärvi, G., Jernström, B., Seidel, A., and Stenius U. Anti-diol epoxide of benzo[a]pyrene induces transient Mdm2 and p53 Ser15 phosphorylation, while anti-diol epoxide of dibenzo[a,l]pyrene induces a nontransient p53 Ser15 phosphorylation. Mol Carcinog, 47, 301-309 (2008).

 


  201.  Kollock, R., Meinl, W., Schneider, H., Batke, M., Frank, H., Seidel, A. and Glatt, H. Efficient oxidation of promutagenic hydroxymethylpyrenes by cDNA-expressed human alcohol dehydrogenase ADH2 and its inhibition by various agents. Biochem. Pharmacol., 75, 527-537 (2008).

 

2007   200.  Pesch, B., Kappler, M., Straif, K., Marczynski, B., Preuss, R., Rossbach, B., Rihs, H.P., Weiss, T., Rabstein, S., Pierl, C., Scherenberg, M., Adams, A., Kafferlein, H.U., Angerer, J., Wilhelm, M., Seidel, A. and Bruning, T. Dose-response modeling of occupational exposure to polycyclic aromatic hydrocarbons with biomarkers of exposure and effect. Cancer Epidemiol. Biomarkers Prev., 16, 1863-1873 (2007).

 


  199.  Bakhiya, N., Batke, M., Laake, J., Monien, B.H., Frank, H., Seidel, A., Engst, W. and Glatt, H. Directing role of organic anion transporters in the excretion of mercapturic acids of alkylated polycyclic aromatic hydrocarbons. Drug Metab. Dispos., 35, 1824-1831 (2007).

 


  198.  Halter, R., Hansen, T., Seidel, A., Ziemann, C., and Borlak, J. Importance of DNA-adduct formation and gene expression profiling of disease candidate genes in rats exposed to bitumen fumes. J. Occup. Environ. Hyg, 4 (Suppl 1) 44-64 (2007).

 


  197.  Yagi, H., Frank, H., Seidel, A., and Jerina, D.M. Synthesis and absolute configuration of cis and trans opened cyclopenta[cd]pyrene 3,4-oxide N2-deoxyguanosine adducts: conversion to phosphoramidites for oligonucleotide synthesis. Chem. Res. Toxicol. 20, 650-661 (2007)

 


  196.  Hansen, T., Seidel, A., and Borlak, J. The environmental carcinogen 3-nitrobenzanthrone and its main metabolite 3-aminobenzanthrone induce production of reactive oxygen intermediates in human epithelial lung cells. Toxicol Appl Pharmacol, 221, 222–234 (2007).

 


  195.  Glatt, H.R., Schneider, H., Seidel, A. Polycyclische aromatische Kohlenwasserstoffe. In: Handbuch der Lebensmitteltoxikologie (H. Dunkelberg, T. Gebel, A. Hartwig, eds.), Wiley-VCH Verlag, Weinheim, 2007, 1121-1155.

 


  194.  Ebert, B., Seidel, A., and Lampen, A. Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate. Toxicol. Sci. 96, 227-236 (2007)

 


  193.  Rihs, H.-P., John, A., Scherenberg, M., Seidel, A., and Brüning, T. Concordance between the deduced acetylation status generated by Real-time PCR based NAT2 genotyping of seven single nucleotide polymorphisms and human NAT2 phenotypes determined with caffeine. Clinica Chim. Acta, 376, 240-243 (2007).

 

2006   192.  Simon, R., Palme, S., Anklam E. and Collaborators: L. Delaire; V. Hanot; H. Holzer; W. Jira; C. Levasseur; F. Monteau; M.W. Obiedzinski; M. Ojala; D. Peschke; S. Ramakrishnan; C. Ranta; A. Ruthenschrör; M. Schirmacher; A. Seidel; P. Sopelana; G. Wolz; and C. Wright. Method Validation for Determination of the 15 European-Priority Polycyclic Aromatic Hydrocarbons in Primary Smoke Condensates by Gas Chromatography/Mass Spectrometry: Interlaboratory Study. Journal of AOAC International, 89, 772-781 (2006).

 


  191.  Wang, B., Sayer, J.M., Yagi, H., Frank, H., Seidel, A., and Jerina, D.M. Facile interstrand migration of the hydrocarbon moiety of a dibenzo[a,l]pyrene 11,12-diol 13,14-epoxide adduct at N2 of deoxyguanosine in a duplex oligonucleotide. J. Am. Chem. Soc. 128, 10079-10084 (2006).

 


  190.  Schober, W., Luch, A., Soballa, V.J., Raab, G., Stegeman, J.J., Doehmer, J., Jacob, J. and Seidel, A. On the species-specific biotransformation of dibenzo[a,l]pyrene. Chem. Biol. Interact. 161, 37-48 (2006).

 


  189.  Bakhiya, N., Stephani, M., Seidel, A., Bahn, A., Ugele, B., Burckhardt, G. and Glatt, H.R. Uptake of chemically reactive, DNA-damaging sulfuric acid esters into renal cells by human organic anion transporters. J. Am. Soc. Nephrol. 17, 1414-1421 (2006).

 

2005   188.  van Lipzig, M.M.H., Vermeulen, N.P.E., Gusino, R., Legler, J., Frank, H., Seidel. A., and Meerman, J.H.N. Formation of estrogenic metabolites of benzo[a]pyrene and chrysene by cytochrome P450 activity and their combined and supra-maximal estrogenic activity. Environ. Toxicol. Pharmacol. 19, 41-55 (2005).

 


  187.  Musafija-Jeknic, T., Luch, A., Seidel, A., Johns, C., Pereira, C., and Baird, W.M., Effect of nucleotide sequence on the binding of (–)-anti-dibenzo[a,l]pyrene-11,12-diol 13,14-epoxide to short oligodeoxyribonucleotides. Polycycl. Aromat. Compds. 25, 103-111 (2005).

 


  186.  Seidel, A. Biomonitoring of PAHs - Human Exposure, in “The carcinogenic effects of polycyclic aromatic hydrocarbons” (Luch, A., ed.) Imperial College Press (ICP), London (UK) p 97-136 (2005).

 


  185.  Ebert, B., Seidel, A., and Lampen, A. Identification of BCRP as transporter of benzo[a]-pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists. Carcinogenesis, 26, 1754-1763 (2005).

 


  184.  Ebert, B., Jacob, J., Seidel, A., and Lampen, A. Oltipraz, flavone and indole-3-carbinol enhance the formation and transport of sulfate conjugates of benzo[a]pyrene in human enterocytes. Tox. Lett. 157, 140-151 (2005).

 


  183.  Mensing, T., Marczynski, B., Engelhardt, B., Wilhelm, M., Preuss, R., Kappler, M., Angerer, J., Käfferlein, H.U., Scherenberg, M., Seidel, A., Brüning, T. DNA adduct formation of benzo[a]pyrene in white blood cells of workers exposed to polycyclic aromatic hydrocarbons. Int. J. Hyg. Environ. Health. 208, 173-178 (2005).

 


  182.  Rihs, H.-P., Pesch, B., Kappler, M., Rabstein, S., Roßbach, B., Angerer, J., Scherenberg, M., Adams, A., Wilhelm, M., Seidel, A., and Brüning, T. Occupational exposure to polycyclic aromatic hydrocarbons in German industries: Association between ambient exposure and urinary metabolites and its modulation by enzyme polymorphisms. Tox. Lett. 157, 241-255 (2005).

 


  181.  Dreij, K., Seidel, A., and Jernström, J. Differential removal of DNA-adducts derived from anti-diol epoxides of dibenzo[a,l]pyrene and benzo[a]pyrene in human cells. Chem Res. Toxicol. 18, 655-664 (2005).

 


  180.  Marczynski, B., Preuss, R., Mensing, T., Angerer, J., Seidel, A., El Mourabit, A., Wilhelm, M., and Brüning, T. Genotoxic risk assessment in white blood cells of occupationally exposed workers before and after alteration of the polycyclic aromatic hydrocarbon (PAH) profile in the production material: comparison with PAH air and urinary metabolite levels. Int Arch Occup Environ Health 78, 98-108 (2005).

 

2004   179.  Angerer, J., Roßbach, B., und Seidel, A. Bestandsaufnahme zur Frage des Zusammenhangs zwischen dem DNA-Adduktgehalt in weißen Blutzellen und in humanem Lungengewebe. In: Poly-cyclische aromatische Kohlenwasserstoffe – DFG Forschungsbericht (Jacob, J., und Greim, H., Hrsg.) WILEY-VCH Verlag GmbH & Co KGaA, (Weinheim) S. 77-117 (2004).

 


  178.  Seidel, A., und Angerer, J., Nukleobasen-Addukte von PAH im Humanurin. In: Poly-cyclische aromatische Kohlenwasserstoffe – DFG Forschungsbericht (Jacob, J., und Greim, H., Hrsg.) WILEY-VCH Verlag GmbH & Co KGaA, (Weinheim) S. 70-76 (2004).

 


  177.  Jacob, J., und Seidel, A. Biomonitoring von PAH-Metaboliten im Humanurin. In: Polycyclische aromatische Kohlenwasserstoffe – DFG Forschungsbericht (Jacob, J., und Greim, H., Hrsg.) WILEY-VCH Verlag GmbH & Co KGaA, (Weinheim) S. 42-69 (2004).

 


  176.  Jacob, J., und Seidel, A. Verwendung eines auf Wirkungsäquivalenten basierenden Summenparameters für die Abschätzung der PAH-Exposition und ihres Krebs erregenden Potentials. In: Polycyclische aromatische Kohlenwasserstoffe – DFG Forschungsbericht (Jacob, J., und Greim, H., Hrsg.) WILEY-VCH Verlag GmbH & Co KGaA, (Weinheim) S. 8-22 (2004).

 


  175.  Seidel, A., Frank, H., Behnke, A., Schneider, D., and Jacob, J. Determination of dibenzo[a,l]pyrene and other fjord-region PAH isomers with mw 302 in environmental samples. Polycycl. Aromat. Compds., 24, 759-771 (2004).

 


  174.  Dreij, K. Bajak E., Sundberg K., Cotgreave I., Jernström. B., Seidel, A. and Gusnanto A. DNA adducts of benzo[a]pyrene- and dibenzo[a,l]pyrene-diol epoxides in human lung epithelial cells: kinetics of adduct removal, effects on cell cycle checkpoints, and gene expression. Polycycl. Aromat. Compds., 24, 549-566 (2004).

 


  173.  Päärjävi, G. Jernström. B., Stenius, U., and Seidel, A. Exposure of mammalian cells to diol epoxides from benzo[a]pyrene and dibenzo[a,l]pyrene and effects on Mdm2 and p53. Polycycl. Aromat. Compds., 24, 537-548 (2004).

 


  172.  Lampen, A., Ebert, B., Stumkat, L., Jacob, J., and Seidel, A. Induction of gene expression of xenobiotic metabolism enzymes and ABC-transport proteins by PAH and a reconstituted PAH mixture in human Caco-2 cells. Biochim. Biophys. Acta 1681, 38-46 (2004).

 

2003   171.  Wu, J., Zhu, B.B., Yu, J., Zhu, H., Qiu, L., Kindy, M.S., Gu, L., Seidel, A., Li, G.M. In vitro and in vivo modulations of benzo[c]phenanthrene-DNA adducts by DNA mismatch repair system. Nucleic Acids Res. 31, 6428-6434 (2003).

 


  170.  Arlt, V.M., Glatt, H.R., Muckel, E., Pabel, U., Sorg, B.L., Seidel, A., Frank, H., Schmeiser, H.H., and Phillips, D.H. Activation of 3-nitrobenzanthrone and its metabolites by human acetyltransferases, sulfotransferases and cytochrome P450 expressed in Chinese hamster V79 cells. Int. J. Cancer 105, 583-592 (2003).

 


  169.  Mahadevan, B., Dashwood, W.-M., Luch, A., Pecaj, A., Doehmer, J., Seidel, A., and Baird, W.M. Mutations induced by (–)-anti-11R,12S-dihydrodiol 13S,14R-epoxide of dibenzo[a,l]pyrene in the coding region of the hypoxanthine phosphoribosyltransferase (hprt) gene in Chinese hamster V79 cells. Environ. Mol. Mutagen. 41, 131-139 (2003).

 


  168.  Arlt V.M., Bernd L. Sorg, B.L., Osborne, M., Hewer, A., Seidel, A., Schmeiser, H.H., and Phillips, D.H. DNA adduct formation by the ubiquitous environmental pollutant 3-nitro-benzanthrone and its metabolites in rats. Biochem. Biophys. Res. Commun. 300, 107-114 (2003).

 


  167.  Buesen, R., Mock, M., Nau, H., Seidel, A., Jacob, J., and Lampen, A. Evidence for an active transport of polar [14C]-benzo[a]pyrene metabolites in human intestinal Caco-2 cells. Chem.-biol. Interact. 142, 201-344 (2003).

 

2002   166.  Buesen, R., Mock, M., Seidel, A., Jacob, J., and Lampen, A. Interaction between metabolism and transport of benzo[a]pyrene and its metabolites in enterocytes. Toxicol. Appl. Pharmacol. 183, 168-178 (2002).

 


  165.  Sundberg, K., Dreij, K., Jernström, B. and Seidel, A., Detoxification of polycyclic aromatic hydrocarbon diol epoxides by human glutathione transferases: efficiency of conjugation in intact cells relative to purified enzymes. Polycycl. Aromat. Compds., 22, 947-953 (2002).

 


  164.  Dreij, K., Sundberg, K., Jernström, B., Johansson, A.-S., Mannervik, B., and Seidel, A., Inactivation of carcinogenic diol epoxides of dibenzo[a,l]pyrene (dibenzo[def,p]chrysene by human alpha class glutathione transferases. Polycycl. Aromat. Compds., 22, 823-829 (2002).

 


  163.  Luch, A., Greim, H., Buters, J.T.M., Mahadevan, B., Baird, W.M., Doehmer, J., Seidel, A., and Glatt, H.R., The role of cytochrome P450 1B1 in dibenzo[a,l]pyrene-induced carcinogenesis. Polycycl. Aromat. Compds., 22, 781-789 (2002).

 


  162.  Baird, W.M., Hooven, L.A., Mahadevan, B., Luch, A., Seidel, A., Iversen, P.L., Responses of human cells to PAH-induced DNA damage. Polycycl. Aromat. Compds., 22, 771-780 (2002).

 


  161.  Jacob, J. and Seidel, A., Biomonitoring of polycyclic aromatic hydrocarbons (review) J. Chromatogr. B 778, 31-47 (2002).

 


  160.  Dreij, K., Sundberg, K., Johansson, A.-S., Nordling, E., Seidel, A., Persson, E., Mannervik, B., and Jernström, B. Catalytic activities of human alpha class glutathione transferases towards carcinogenic dibenzo[a,l]pyrene diol epoxides. Chem. Res. Toxicol. 15, 825-831 (2002).

 


  159.  Jacob, J. and Seidel, A. Zur Problematik der Verwendung von Benzo[a]pyren als Leitkomponente für das PAH-bedingte karzinogene Potential in Umweltmatrices. Gefahrstoffe - Reinhaltung der Luft, 62, 239-246 (2002).

 


  158.  Platt, K.-L., Degenhardt, C., Grupe, S., Frank, H., and Seidel, A. Microsomal activation of anthanthrene, a hexacyclic aromatic hydrocarbon without a bay-region, to mutagenic metabolites. Chem. Res. Toxicol. 15, 332-342 (2002).

 


  157.  Seidel, A., Dahmann, D., Krekeler, H., and Jacob, J. Biomonitoring of polycyclic aromatic compounds in the urine of mining workers occupationally exposed to diesel-exhaust. Inter. J. Hyg. Environ. Health, 204, 333-338 (2002).

 


  156.  Sundberg, K., Dreij, K., Seidel, A., and Jernström, B. Glutathione conjugation and DNA adduct formation of dibenzo[a,l]pyrene and benzo[a]pyrene diol epoxides in V79 cells stably expressing different human glutathione transferases. Chem. Res. Toxicol. 15, 170-179 (2002).

 


  155.  Schwerdtle, T., Seidel, A., and Hartwig, A. Effect of soluble particulate nickel compounds on the formation and repair of stable benzo[a]pyrene DNA adducts in human lung cells. Carcinogenesis, 23, 47-53 (2002).

 

2001   154.  Seidel, A., Grimmer, G., Dettbarn, G., and Jacob, J. Nachweis von kanzerogenen aromatischen Aminen im Harn von Nichtrauchern. Umweltmed. Forsch. Prax. 6, 213-220 (2001).

 


  153.  Mahadevan, B., Luch, A., Seidel, A., Pelling, J.C., and Baird, W.M. Effects of (–)-anti-11R,12S-dihydrodiol 13S,14R-epoxide of dibenzo[a,l]pyrene on DNA adduct formation and cell cycle arrest in human diploid fibroblasts. Carcinogenesis, 22, 161-169 (2001).

 

2000   152.  Ma, L., Landsiedel, R., Seidel, A., and Glatt, H.R. Detection of mercapturic acids and nucleoside adducts in blood, urine and faeces of rats treated with 1-hydroxy-methylpyrene. Polycycl. Arom. Compds., 21, 135-149 (2000).

 


  151.  Sundberg, K., Townsend, A., Luch, A., Seidel, A., and Jernström, B. Effect of glutathione transferases on DNA-adduct formation of polycyclic aromatic hydrocarbons in mammalian cells. Polycycl. Arom. Compds., 21, 123-133 (2000).

 


  150.  Jacob, J., Schober, W., Raab, G., Frank, H., Luch, A., Doehmer, J., and Seidel, A. Species dependent metabolism of benzo[c]chrysene mediated by c-DNA-expressed human, rodent and fish cytochrome P450 enzymes. Polycycl. Arom. Compds., 21, 109-121 (2000).

 


  149.  Luch, A., Schober, W., Greim, H., Doehmer, J., Jacob, J., Seidel, A., and Baird, W.M. Metabolic activation of dibenzo[a,l]pyrene by cytochrome P450 enzymes to stable DNA adducts occurs exclusively through the formation of the (–)-trans-(11R,12R)-dihydrodiol. Polycycl. Arom. Compds., 21, 87-98 (2000).

 


  148.  Borlak, J., Hansen, T., Yuan, X.Y., Sikka, H.C., Kumar, S., Schmidbauer, S., Raab, G., Frank, H., Jacob, J., and Seidel, A. Metabolism and DNA binding of 3-nitrobenzanthrone in human fetal bronchial epithelial and alveolar typ II cells. Polycycl. Arom. Compds., 21, 73-86 (2000).

 


  147.  Kroth, H., Yagi, H., Seidel, A., and Jerina, D.M. New and highly efficient synthesis of cis- and trans-opened benzo[a]pyrene 7,8-diol 9,10-epoxide adducts at the exocyclic amino group of deoxyguanosine. J. Org. Chem., 65, 5558-5564 (2000).

 


  146.  Doehmer, J., Krebsfänger, N., Schober, W., Luch, A., Buters, J.T.M., Jacob, J., Seidel, A., Mürdter, T., Zanger, U.M., and Eichelbaum, M. Building a bio-technology platform for metabolism studies in pharmacology and toxicology. In: Progress in the Reduction, Refinement and Replacement of Animal Experimentation, (Balls, M., van Zeller, A.-M., and Halder, M.E., ed's), Elsevier Science B.V., pp 139-146 (2000).

 


  145.  Buterin, T., Hess, M.T., Luneva, N., Geacintov, N.E., Amin, S., Kroth, H., Seidel, A., and Naegeli, H. Unrepaired fjord region polycyclic aromatic hydrocarbon-DNA adducts in ras codon 61 mutational hot spots, Cancer Res., 60, 1849-1856 (2000).

 


  144.  Li, D.N., Seidel, A., Pritchard, M.P., Wolf, C.R., and Friedberg, T. Polymorphisms in P450 CYP1B1 affect the conversion of estradiol to the potentially carcinogenic metabolite 4-hydroxyestradiol. Pharmacogenetics, 10, 343-353 (2000).

 


  143.  Grimmer, G., Dettbarn, G., Seidel, A., and Jacob, J. Detection of carcinogenic aromatic amines in the urine of non-smokers. Sci. Total Environ., 247, 81-90 (2000).

 


  142.  Melendez-Colon, V.J., Luch, A., Seidel, A., and Baird, W.M. Formation of stable DNA adducts and apurinic sites upon metabolic activation of bay and fjord region polycyclic aromatic hydrocarbons in human cell cultures. Chem. Res. Toxicol., 13, 10-17 (2000).

 

1999   141.  Sundberg, K., Seidel, A., Mannervik, B., and Jernström, B., Catalytic efficiency of glutathione transferase P1-1 variants towards bay- and fjord-region diol epoxides of polycyclic aromatic hydrocarbons. Polycycl. Aromat. Compds., 17, 43-51 (1999).

 


  140.  Pradhan, P., Gräslund, A., Seidel, A., and Jernström, B., Studies on adduct formation of (+)-anti-benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide with the oligonucleotides 5'-d(CCTA TCGTTATCC) and 5'-d(CCTATCm5GTTATCC). Polycycl. Aromat. Compds., 17, 21-32 (1999).

 


  139.  Jacob, J., Raab, G., Soballa, V.J., Luch, A., Grimmer, G., Greim, H., Doehmer, J., Morrison, H.G., Stegeman, J.J., and Seidel, A., Species-dependent metabolism of benzo[c]phenanthrene and dibenzo[a,l]pyrene by various CYP450 isoforms. Polycycl. Aromat. Compds., 16, 191-203 (1999).

 


  138.  Baird, W.M., Kaspin, L.C., Kudla, K., Seidel, A., Greim, H., and Luch, A., Relationship of dibenzo[a,l]pyrene-DNA binding to the induction of p53, p21WAF1 and cell cycle arrest in human cells in culture. Polycycl. Aromat. Compds., 16, 119-129 (1999).

 


  137.  Luch, A., Coffing, S.L., Seidel, A., Greim, H., Baird, W.M., and Doehmer, J., DNA modification induced after metabolic activation of the potent carcinogen dibenzo[a,l]pyrene in V79 Chinese hamster cells stably expressing single cytochromes P450. Polycycl. Aromat. Compds., 16, 71-78 (1999).

 


  136.  Pradhan, P., Gräslund, A., Seidel, A., and Jernström, B. Implications of cytosine methylation on (+)-anti-benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide N2-dG adduct formation in 5'-d(CGT), 5'-d(CGA), and 5'-d(CGC) sequence contexts of single- and double-stranded oligonucleotides. Chem. Res. Toxicol., 12, 816-821 (1999).

 


  135.  Luch, A., Kishiyama, S., Seidel, A., Doehmer, J., Greim, H., and Baird, W.M. The K-region trans-8,9-diol does not significantly contribute as an intermediate in the metabolic activation of dibenzo[a,l]pyrene to DNA-binding metabolites by human cytochrome P450 1A1 or 1B1. Cancer Res., 59, 4603-4609 (1999).

 


  134.  Li, K.-M., George, M., Gross, M.L., Lin, Ch.-H., Small, G.J., Jankowiak, R., Seidel, A., Kroth, H., Eleanor G. Rogan, E.L., and Cavalieri, E.L. Structure elucidation of the adducts formed by fjord-region dibenzo[a,l]pyrene 11,12-diol 13,14-epoxides with deoxy­guanosine. Chem. Res. Toxicol., 12, 778-788 (1999).

 


  133.  Li, K.-M., George, M., Gross, M.L., Seidel, A., Luch, A., Rogan, E.G., and Cavalieri, E.L. Structure elucidation of the adducts formed by fjord-region dibenzo[a,l]pyrene 11,12-diol 13,14-epoxides with deoxyadenosine. Chem. Res. Toxicol., 12, 758-767 (1999).

 


  132.  Pal, A., Seidel, A., Xia, H., Hu, X., Oesch, F., and Singh, S.V. Specificity of murine glutathione S-transferase isozymes in the glutathione conjugation of (-)-anti- and (+)-syn-stereoisomers of benzo[g]chrysene 11,12-dihydrodiol 13,14-epoxide. Carcinogenesis, 20, 1997-2001 (1999).

 


  131.  Melendez-Colon, V.J., Luch, A., Seidel, A., and Baird, W.M. Cancer initiation by polycyclic aromatic hydrocarbons results from formation of stable DNA adducts rather than apurinic sites. Carcinogenesis, 20, 1885-1891 (1999).

 


  130.  Pradhan, P., Jernström, B., Seidel, A., Nordén, B., and Gräslund, A. Studies on the adduct heterogeneity of benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide stereo-isomers covalently bound to deoxyribooligonucleotides by induced circular dichroism and light absorption spectroscopy. Chem. Res. Toxicol., 12, 403-411 (1999).

 


  129.  Bluvshtein, E., Glass, G.A., Volohonsky, G., Yaakubowitz, M., Harness, E., Smorodinsky, N., Seidel, A., Frank, H., Steinberg, P., and Stark, A.A. Inhibition of the hydrolytic and transpeptidase activities of rat kidney g-glutamyl-transpeptidase by specific monoclonal antibodies. Eur. J. Biochem., 260, 844-854 (1999).

 


  128.  Melendez-Colon, V.J., Luch, A., Seidel, A., and Baird, W.M. Comparison of cytochrome P450 and peroxidase dependent metabolic activation of the potent carcinogen dibenzo[a,l]pyrene in human cell lines: formation of stable DNA adducts and absence of a detectable increase in apurinic sites. Cancer Res., 59, 1412-1416 (1999).

 


  127.  Luch, A., Friesel, H., Seidel, A., and Platt, K.L. Tumor-initiating activity of the (+)-(S,S)- and (-)-(R,R)-enantiomers of trans-11,12-dihydroxy-11,12-dihydrodibenzo[a,l]pyrene in mouse skin. Cancer Lett. 136, 119-128 (1999).

 


  126.  Luch, A., Schober, W., Soballa, V.J., Raab, G., Greim, H., Jacob, J., Doehmer, J. and Seidel, A. Metabolic activation of dibenzo[a,l]pyrene by human cytochrome P450 1A1 and P450 1B1 expressed in V79 Chinese hamster cells. Chem. Res. Toxicol. 12, 353-364 (1999).

 


  125.  Erb, C., Seidel, A., Frank, H., Platt, K.L., Oesch, F., and Klein, J. Formation of N-methyl­nicotinamide in the brain from a dihydropyridine-type pro-drug: Effect on brain choline.. Biochem. Pharmacol. 57, 681-684 (1999).

 


  124.  Luch, A., Kudla, K., Seidel, A., Doehmer, J., Greim, H., and Baird, W.M. The level of DNA modification by (+)-syn-(11S,12R,13S,14R)- and (-)-anti-(11R,12S,13S,14R)-dihydrodiol epoxides of dibenzo[a,l]pyrene determines the effect on the proteins p53 and p21WAF1 in the human mammary carcinoma cell line MCF-7. Carcinogenesis, 20, 859-865 (1999).

 


  123.  Bock, K.W., Raschko, F.T., Gschaidmeier, H., Seidel, A., Oesch, F., Grove, A.D., Ritter, J.K. Mono- and diglucuronide formation from benzo[a]pyrene and chrysene diphenols by AHH-1 cell-expressed UDP-glucuronosyltransferase UGT1A7. Biochem. Pharmacol., 57, 653-656 (1999).

 


  122.  Doehmer, J., Buters, J.T.M., Luch, A., Soballa, V., Baird, W.M., Morisson, H., Stegeman, J.J., Townsend, A.J., Greenlee, W.F., Glatt, H.R., Seidel, A., Jacob, J., and Greim, H. Molecular studies on the toxifying effects by genetically engeneered cytochromes P450. Drug Met. Rev., 31, 423-435 (1999).

 

1998   121.  Sundberg, K., Seidel, A., Mannervik, B. and Jernström, B. Detoxification of carcinogenic fjord-region diol epoxides of polycyclic aromatic hydrocarbons by glutathione transferase P1-1 variants and glutathione. FEBS Lett., 438, 206-210 (1998).

 


  120.  Seidel, A., Friedberg, T., Löllmann, B., Schwierzok, A., Funk, M., Frank, H., Holler, R., Oesch, F., and Glatt, H.R. Detoxication of optically active bay- and fjord-region polycyclic aromatic hydrocarbon dihydrodiol epoxides by human glutathione transferase P1-1 expressed in Chinese hamster V79 cells. Carcinogenesis, 19, 1975-1981 (1998).

 


  119.  Hu, X., Seidel, A., Frank, H., Srivastava, S.K., Xia, H., Pal, A., Zheng, S., Oesch, F., and Singh, S.V., Differential enantioselectivity of murine glutathione S-transferase isoenzymes in the glutathione conjugation of trans-3,4-dihydroxy-1,2-oxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene stereoisomers. Ach. Biochem. Biophys., 358, 40-48 (1998).

 


  118.  Landsiedel, R., Frank, H., Glatt, H.R., and Seidel, A. Optical resolution of trans-dihydrodiol enantiomers of fjord-region polycyclic aromatic hydrocarbons by HPLC on a chiral cellulose-phase: relationship between elution order and absolute configuration. J. Chromatogr. A, 822, 29-35 (1998).

 


  117.  Khan, Q.A., Agarwal, R., Seidel, A., Frank, H., Vousden, K.H., and Dipple, A. Effects of optical isomers of benzo[g]chrysene anti dihydrodiol epoxide on passage of MCF-7 cells through the cell cycle. Mol. Carcinog. 23, 115-120 (1998).

 


  116.  Luch, A., Schneider, A., Coffing, S. L., Soballa, V. J., Greim, H., Jefcoate, C.R., Greenlee, W.F., Seidel, A., Baird, W.M., and Doehmer, J. Stable expression of human cytochrome P450 1B1 in V79 Chinese hamster cells and metabolically catalyzed DNA adduct formation of dibenzo[a,l]pyrene. Chem. Res. Toxicol., 11, 686-695 (1998).

 


  115.  Jankowiak, R., Ariese, F., Hewer, A., Luch, A., Zamzow, D., Hughes, N.C., Phillips, D., Seidel, A., Platt, K.L., Oesch, F., and Small, G.J. Structure, conformations, and repair of DNA adducts from dibenzo[a,l]pyrene: 32P-Postlabeling and fluorescence studies. Chem. Res. Toxicol. 11, 674-685 (1998).

 


  114.  Landsiedel, R., Pabel, U., Engst, W., Ploschke, J., Seidel, A. and Glatt, H.R. Chiral inversion of 1-hydroxymethylpyrene enantiomers mediated by enantioselective sulfotransferases. Biochem. Biophys. Res. Commun., 247, 181-185 (1998).

 


  113.  Seidel, A., Soballa, V.J., Raab, G., Frank, H., Grimmer, G., Greim, H., Jacob, J., and Doehmer, J. Regio- and stereoselectivity in the metabolism of benzo[c]phenanthrene mediated by genetically engineered V79 Chinese hamster cells expressing rat and human cytochromes P450. Environ. Toxicol. Pharmacol., 5, 179-196 (1998).

 


  112.  Luch, A., Platt, K.L., and Seidel, A. Synthesis of fjord region tetraols and their use in hepatic biotransformation studies of dihydrodiols of benzo[c]chrysene, benzo[g]chrysene and dibenzo[a,l]pyrene. Carcinogenesis, 19, 639-648 (1998).

 


  111.  Pradhan, P., Jernström, B., Seidel, A., Nordén, B., and Gräslund, A. Induced circular dichroism of benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide stereoisomers covalently bound to deoxyribooligonucleotides used to probe equilibrium distribution between groove binding and intercalative adduct conformations. Biochemistry, 37, 4664-4673 (1998).

 


  110.  Glatt, H.R., Bartsch, I., Christoph, St., Coughtrie, M.W.H., Falany, C.N., Hagen, M., Landsiedel, R., Pabel, U., Phillips, D.H., Seidel, A., Yamazoe, Y. Sulfotransferase-mediated activation of mutagens, studied using heterologous expression systems. Chem.-biol. Interact., 109, 195-219 (1998).

 


  109.  Sundberg, K., Johansson, A.S., Stenberg, G., Widersten, M., Seidel, A., Mannervik, B. and Jernström, B. Differences in the catalytic efficiencies of allelic variants of glutathione transferase P1-1 towards carcinogenic diol epoxides of polycyclic aromatic hydrocarbons. Carcinogenesis 19, 433-436 (1998).

 

1997   108.    Melendez-Colon, V.J., Smith, C.A., Seidel, A., Luch, A., Platt, K.L., and Baird, W.M. Formation of stable adducts and absence of depurinating adducts upon reaction of the diol epoxides of the potent carcinogen dibenzo[a,l]pyrene with DNA in solution and in cells. Proc. Natl. Acad. Sci. U.S.A., 94, 13542-13547 (1997).

 


  107.    Giles, A.S., Seidel, A., and Phillips, D.H. Covalent DNA adducts formed by benzo[c]-chrysene in mouse epidermis and by benzo[c]chrysene fjord-region diol-epoxides reacted with DNA and polynucleotides. Chem. Res. Toxicol., 10, 1275-1284 (1997).

 


  106.    Sundberg, K., Widersten, M., Seidel, A., Mannervik, B., and Jernström, B. Glutathione conjugation of bay- and fjord-region diol epoxides of polycyclic aromatic hydrocarbons by glutathione transferases M1b-1b and P1-1. Chem. Res. Toxicol. 10, 1221-1227 (1997).

 


  105. Luch, A., Seidel, A., Glatt, H.R., and Platt, K.L. Metabolic activation of the (+)-(S,S)- and (-)-(R,R)-enantiomers of trans-11,12-dihydroxy-11,12-dihydrodi-benzo[a,l]pyrene: stereo-selectivity, DNA adduct formation, and mutagenicity in Chinese hamster V79 cells. Chem. Res. Toxicol. 10, 1161-1170 (1997).

 


  104. Funk, M., Pontén, I., Seidel, A., and Jernström, B. Critical parameters for adduct formation of the four stereoisomeric benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxides with oligo­nucleotides. Bioconjugate Chem., 8, 310-317 (1997).

 


  103. Steinberg, P., Heck, R., Frank, H., Odenthal, M., Dienes, H.-P., and Seidel, A. The role of the Ha-ras gene in the malignant transformation of rat liver oval cells. Inter. J. Cancer. 71, 680-685 (1997).

 


  102. Ralston, S., Coffing, S., Seidel, A., Luch, A., Platt, K.L., and Baird, W.M. Stereoselective activation of dibenzo[a,l]pyrene and its trans-11,12-dihydrodiol to fjord region 11,12-diol 13,14-epoxides in a human mammary carcinoma MCF-7 cell-mediated V79 cell mutation assay. Chem. Res. Toxicol. 10, 687-693 (1997).

 


  101. Jankowiak, R., Ariese, F., Zamzow, D., Luch, A., Kroth, H., Seidel, A., and Small, G.J. Conformational studies of stereoisomeric tetraols derived from syn- and anti-dibenzo[a,l]pyrene diolepoxides. Chem. Res. Toxicol. 10, 677-686 (1997).

 


  100. Hanelt, S., Helbig, R., Hartmann, A., Lang, M., Seidel, A., and Speit, G. (1997) A comparative investigation of DNA adducts, DNA strand breaks and gene mutations induced by benzo[a]pyrene and (±)-benzo[a]pyrene-7,8-diol-9,10-epoxide in cultured human cells. Mutagenesis 390, 179-188 (1997).

 


  99. Müller, F., Arand, A., Frank, H., Seidel, A., Hinz, W., Winkler, L., Hänel, K., Blée, E., Beetham, J.K., Hammock, B.D., and Oesch, F. Visualization of the covalent intermediate formed between microsomal epoxide hydrolase and 9,10-epoxystearic acid during enzymatic epoxide hydrolysis. Eur. J. Biochem., 245, 490-496 (1997).

 


  98. Turchi, G., Glatt, H.R., Seidel, A., Puliti, A., and Sbrana, I. Structure-activity relationship in the induction of chromosomal aberrations and spindle disturbances in Chinese hamster epithelial liver cells by regioisomeric phenanthrene quinones. Cell Biol. Toxicol., 13, 155-165 (1997).

 

1996   97. Kroth, H., Oesch, F., and Seidel, A. Synthesis of stereoisomeric N6-deoxy-adenosine adducts of syn- and anti-dihydrodiol epoxides of benzo[a]pyrene and their incorporation into 18-mer DNA sequences from human Ha-ras protooncogene. Polycycl. Arom. Compds., 11, 349-356 (1996).

 


  96. Landsiedel, R., Engst, W., Scholtyssek, M., Seidel, A., Glatt, H.R. Nucleophilic displacement reactions at the benzylic position of the sulfuric acid ester 1-sulfo-oxymethylpyrene: Potential influence on in vivo reactivity. Polycycl. Arom. Compds., 11, 341-348 (1996).

 


  95. Buchwald-Goebel, S., Oesch, F., and Seidel, A. A tandem photochemical approach for the synthesis of biologically important metabolites of benzo[b]fluoranthene. Polycycl. Arom. Compds., 11, 325-332 (1996).

 


  94. Steinberg, P., Oesch, F., and Seidel, A. The stereoisomeric fjord-region benzo[c]-phenanthrene-3,4-dihydrodiol 1,2-oxides malignantly transform rat liver epithelial cells. Polycycl. Arom. Compds., 10, 275-282 (1996).

 


  93. Baird, W.M., Ralston, S., Luch, A., Platt, K.L., and Seidel, A. Stereoselective metabolic activation of dibenzo[a,l]pyrene in the human mammary carcinoma cell line MCF-7 results in formation of (-)-anti and (+)-syn-11,12-diol-13,14-epoxide-deoxyadenosine adducts in DNA. Polycycl. Arom. Compds., 10, 235-242 (1996).

 


  92. Pfau, W., Seidel, A., Phillips, D.H., Oesch, F., and Grover, P.L. 32P-postlabelling/ HPLC analysis of DNA adducts formed from chrysene and its metabolites. Polycycl. Arom. Compds., 10, 219-226 (1996).

 


  91. Seidel, A., Sun, Z., Kroth, H., Steinbrecher, T., Oesch, F., and Friedberg, T. DNA-polymerase action on oligonucleotide templates from human Ha-ras proto-oncogenes containing N6-deoxyadenosine adducts derived from trans addition of (+)- and (-)-anti-benzo[c]­phenanthrene-3,4-dihydrodiol 1,2-oxide at Codon 61. Polycycl. Arom. Compds., 10, 161-170 (1996).

 


  90. Frank, H., Luch, A., Oesch, F., and Seidel, A. 4-[4(Dimethylamino)phenylazo]-benzoate, a new red-shifted chromophore for use in the exciton chirality method: Assignment of absolute configuration to fjord-region metabolites of dibenzo[a,l]pyrene. Polycycl. Arom. Compds., 10, 109-116 (1996).

 


  89. Luch, A., Seidel, A., Glatt, H.R., Oesch, F., and Platt, K.L. Correlation of the extent of fjord-region oxidation with DNA binding and mutagenicity of the enantiomeric 11,12-dihydrodiols of dibenzo[a,l]pyrene in vitro. Polycycl. Arom. Compds., 10, 101-108 (1996).

 


  88. Ponten, I., Seidel, A., Gräslund, A., and Jernström, B. Studies on oligonucleotides modified with the enantiomers of the anti- and syn-diastereomers of benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide. Polycycl. Arom. Compds., 10, 93-100 (1996).

 


  87. Degenhardt, C., Bors, W., Seidel, A., Frank, H., and Platt, K.L. Metabolic activation of anthanthrene: Significance of stable radicals derived from its key metabolite 3-hydroxy-anthanthrene. Polycycl. Arom. Compds., 10, 85-92 (1996).

 


  86. Reindl, M., Seidel, A., Frank, H. and Platt, K.L. Detection of reactive quinones in the metabolism of polycyclic aromatic hydrocarbons by the formation of their glutathione conjugates. Polycycl. Arom. Compds., 10, 77-84 (1996).

 


  85. Jernström, B., Mannervik, B., Funk, M., and Seidel, A. Glutathione conjugation of diol epoxides of polycyclic aromatic hydrocarbons catalyzed by human glutathione transferase A1-1. Polycycl. Arom. Compds., 10, 51-57 (1996).

 


  84. Jacob, J., Doehmer, J., Grimmer, G., Soballa, V., Raab, G., Seidel, A., and Greim, H. Metabolism of phenanthrene, benz[a]anthracene, benzo[a]pyrene and benzo[c]­phenanthrene by eight cDNA-expressed human and rat cytochromes. Polycycl. Arom. Compds., 10, 1-9 (1996).

 


  83. Speit, G., Hanelt, S., Helbig, R., Seidel, A. and Hartmann, A. Detection of DNA effects in human cells with the comet assay and their relevance for mutagenesis. Toxicol. Lett., 88, 91-98 (1996).

 


  82. Glatt, H.R., Christoph, S., Czich, A., Pauly, K., Schwierzok, A., Seidel, A., Coughtrie, M.W.H., Doehmer, J., Falany, C.N., Phillips, D.H., Yamazoe, Y., and Bartsch, I. Rat and human sulfotransferases expressed in Ames's Salmonella typhimurium strains and Chinese hamster V79 cells for the activation of mutagens. In: Control Mechanisms of Carcinogenesis (ed's J.G. Hengstler and F. Oesch), Publishing House of the Editors: J.G. Hengstler & F. Oesch, p. 98-115 (1996).

 


  81. Jernström, B., Funk, M., Frank, H., Mannervik, B., and Seidel, A. Glutathione tranferase A1-1 catalyzed conjugation of bay- and fjord-region diol epoxides of polycyclic aromatic hydrocarbons with glutathione. Carcinogenesis, 17, 1491-1498 (1996).

 


  80. Giles, A.S., Seidel, A., and Phillips, D.H. Covalent DNA adducts formed in mouse epidermis by benzo[g]chrysene. Carcinogenesis, 17, 1331-1336 (1996).

 


  79. Windsor, S.A., Tinker, M.H., Osborne, M.R. and Seidel, A. Studies of the binding of diol-epoxide metabolites of polycyclic aromatic hydrocarbons to DNA using electro-fluorescence polarization spectroscopy. Carcinogenesis, 17, 605-608 (1996).

 


  78. Jacob, J., Raab, G., Soballa, V., Holtkamp, D., Schmalix, W., Grimmer, G., Greim, H. Doehmer, J., and Seidel, A. Cytochrome P450-mediated activation of phenanthrene in genetically engineered V79 Chinese hamster cells. Environ. Toxicol. Pharmacol., 1, 1-11 (1996).

 


  77. Pontén, I., Seidel, A., Gräslund, A., and Jernström, B. Characterization of adducts derived from the syn-diastereomer of benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide and the oligo­nucleotide 5'-d(CCTATAGATATCC). Chem. Res. Toxicol., 9, 188-196 (1996).

 

1995   76. Glatt, H., Bartsch I., Czich A., Seidel A. and Falany C.N. Salmonella strains and mammalian cells genetically engineered for expression of sulfotransferases. Toxicol. Lett., 82-3, 829-834 (1995).

 


  75. Ralston, S., Seidel, A., Platt, K.L., Luch, A., and Baird, W.M. Stereochemical selectivity of activation of dibenzo[a,l]pyrene to (-)-anti- and (+)-syn-DB[a,l]P-11,12-diol-13,14-epoxide which bind extensively to deoxyadenosine residues of DNA in the human mammary carcinoma cell line MCF-7. Carcinogenesis, 16, 2899-2907 (1995).

 


  74. Sbrana, I., Puliti, A., Seidel, A., Glatt, H.R., and Turchi, G. Induction of chromosomal aberrations and spindle disturbances in Chinese hamster epithelial liver cells in culture by pyrene and benzo[a]pyrene quinones. Mutagenesis, 10, 505-512 (1995).

 


  73. Du, M.Q., Seidel, A., and Phillips, D.H. Activating mutations in human c-Ha-ras-1 protooncogene induced by the stereoisomeric fjord-region benzo[c]chrysene-9,10-diol 13,14-epoxides. Mol. Carcinogen., 14, 160-169 (1995).

 


  72. Seidel, A., Oesch, F., and Steinberg, P. Malignant transformation of the liver tumor precursor cell line OC/CDE 22 by the four stereoisomeric fjord-region 3,4-dihydrodiol 1,2-epoxides of benzo[c]phenanthrene. Carcinogenesis, 16, 2111-2115 (1995).

 


  71. Goeptar, A.R., te Koppele, J.M., Glatt, H.R., Groot, E.J., Seidel, A., Barrenscheen, M., Wölfel, C., Doehmer, J., Vermeulen, N.P.E. The cytotoxicity of mitomycin C and adriamycin in genetically engeneered V79 cell lines and freshly isolated hepatocytes. Chem.-Biol. Interact., 97, 149-168 (1995).

 


  70. Gschaidmaier, H., Seidel, A., Burchell, B. and Bock, K.W. Formation of mono- and diglucuronides and of other glycosides of benzo[a]pyrene-3,6-quinol by V79 cell-expressed human phenol UDP-glucuronsyltransferase of the UGT1 complex (UGT1.6 and UGT1.07). Biochem. Pharmacol., 49, 1601-1606 (1995).

 


  69. Funk, M., Gath, I., Seidel, A., Oesch, F., and Platt, K.L. Conjugation of anti-dihydrodiol epoxides of benzo[a]pyrene, chrysene, benzo[c]phenanthrene and dibenz[a,h]anthracene with glutathione catalysed by cytosol and by the mu-class glutathione transferase HTP II from rat liver. Chem. Biol. Interact. 95, 189-201 (1995).

 


  68. Giles, A., Seidel, A., and Phillips, D.H. Reactivities towards DNA of the fjord-region diol-epoxides of benzo[g]chrysene and benzo[c]phenanthrene as revealed by 32P-postlabeling. Chem. Res. Toxicol., 8, 591 - 599 (1995).

 


  67. Doehmer, J, Holtkamp, D, Soballa, V., Raab, G., Schmalix, W., Seidel, A., Greim, H. and Jacob, J. Cytochrome P450 mediated reactions studied in genetically engineered V79 Chinese hamster cells. Pharmacogenetics, 5, S91 - S96 (1995).

 

1994   66. Glatt, H.R., Pauly, K., Frank, H., Seidel, A., Oesch, F., Harvey, R.G., and Werle-Scheider, G. Substance-dependent sex differences in the activation of benzylic alcohols to mutagens by hepatic sulfotransferases of the rat. Carcinogenesis, 15, 2605-2611 (1994).

 


  65. Luch, A., Glatt, H.R., Platt, K.L., Oesch, F., and Seidel, A. Synthesis and mutagenicity of the diastereomeric fjord-region 11,12-dihydrodiol 13,14-epoxides of dibenzo[a,l]pyrene. Carcinogenesis, 15, 2507-2516 (1994).

 


  64. Glatt, H.R., Pauly, K., Piée-Staffa, Seidel, A., Hornhardt, S., and Czich, A. Activation of promutagens by endogenous and heterologous sulfotransferases expressed in continous cell cultures. Toxicology Lett., 72, 13-21 (1994).

 


  63. Glatt, H.R., Werle-Schneider, G., Enders, N., Monnerjahn, S., Pudil, J., Czich, A., Seidel, A., and Schwarz, M. 1-Hydroxymethylpyrene and its sulfuric acid ester: toxicological effects in vitro and in vivo, and metabolic aspects. Chem.-Biol. Interact., 92, 305-319 (1994).

 


  62. Glatt, H.R., Werle-Schneider, G., Seidel, A., and Schwarz, M. Initiation and promotion of enzyme-altered foci in rat liver by 1-hydroxymethylpyrene.. Polycycl. Arom. Compds., 7, 153-160 (1994).

 


  61. Glatt, H.R., Pudil, J., Seidel, A., and Czich, A. Stable expression of heterologous sulfo-transferase in V79 cells: activation of primary and secondary benzylic alcohols. Polycycl. Arom. Compds., 7, 67-74 (1994).

 


  60. Ralston, S.L., Lau, H.H.S., Seidel, A., Luch, A., Platt, K.L., and Baird, W.M. Identification of dibenzo[a,l]pyrene-DNA adducts formed in cells in culture and in mouse skin. Polycycl. Arom. Compds., 6, 199-206 (1994).

 


  59. Seidel, A., Luch, A., Platt, K.L., Oesch, F., and Glatt, H.R. Activated fjord-region metabolites of dibenzo[a,l]pyrene: Synthesis and mutagenic activities of the diastereomeric syn- and anti-11,12-dihydrodiol 13,14-epoxides. Polycycl. Arom. Compds., 6, 191-198 (1994).

 


  58. Glatt, H.R., Seidel, A., Oesch, F., and Gumbsch, A. Fjord-region diol-epoxides of benzo[c]chrysene are potent inducers of micronuclei in murine bone marrow. Mutat. Res., 309, 37-43 (1994).

 


  57. Post, K., Seidel, A., Platt, K. L., Oesch, F., and Klein, J. Regiospecific oxidation of dihydrodiols and reduction of quinones by rabbit liver dihydrodiol dehydrogenase. Chem.-Biol. Interact., 90, 157-168 (1994).

 


  56. Funk, M., Gath, I., Seidel, A., Platt, K. L., Oesch, F. and Zeller, H.D. Different enzyme kinetics during the glutathione conjugation of the four stereoisomeric forms of the fjord-region diolepoxide of benzo[c]phenanthrene by the acidic rat liver glutathione S-transferase HTP II. Biochem. Pharmacol., 47, 505-514 (1994) .

 


  55.       Ralston, S.L., Lau, H.H.S., Seidel, A., Luch, A., Platt, K.L., and Baird, W.M. The potent carcinogen dibenzo[a,l]pyrene is metabolically activated to fjord-region 11,12-diol 13,14-epoxides in human mammary carcinoma MCF-7 cell cultures. Cancer Res., 54, 887 - 890 (1994).

 

1993   54. Schmalix, W.A., Mäser, H., Kiefer, F., Reen, R., Wiebel, F.J., Gonzalez, F., Seidel, A., Glatt, H.R., Greim, H., and Doehmer, J. Stable expression of human cytochrome P450 1A1 cDNA in V79 Chinese hamster cells and metabolic activation of benzo[a]pyrene. Eur. J. Pharmacol. - Environ. Toxicol. Pharmacol. Sec., 248, 251 - 261 (1993).

 


  53. Glatt, H. R., Henschler, R., Frank, H., Seidel, A., Oesch, F., Yang, C. X., Abu-Shqara, E., and Harvey, R. G. Sulfotransferase-mediated mutagenicity of 1-hydroxymethyl-pyrene and 4H-cyclopenta[def]chrysen-4-ol and its enhancement by chloride anions. Carcinogenesis, 14, 599-602 (1993).

 


  52. Steinbrecher, T., Becker, A, Stezowski, J.J., Oesch, F., and Seidel, A. Synthesis of oligo­deoxynucleotides containing diastereomeric diol epoxide-N6-deoxy-adenosine adducts of polycyclic aromatic hydrocarbons. Tetrahedron Lett., 34, 1773-1774 (1993).

 


  51. Jernström, B., Funk, M., Steinbrecher, T., and Seidel, A. Glutathione transferase catalyzed conjugation of diol epoxides derived from polycyclic aromatic hydrocarbons with glutathione. Polycycl. Arom. Compds., 3, 213 - 219 (1993).

 


  50. Pfau, W., Lecoq, S., Hughes, N.C., Seidel, A., Platt, K.L., Grover, P.L., and Phillips, D.H. Formation of DNA adducts by 1-hydroxy-methylpyrene in liver cells in vivo and in vitro. In: Postlabelling Methods for Detection of DNA Adducts, IARC Scientific Publication No. 124, IARC, Lyon (France), pp 233 - 242 (1993).

 


  49. Monnerjahn, S., Seidel, A., Steinberg, P., Oesch, F., Hinz, M., Stezowski, J.J., Hewer, A., Phillips, D.H., and Glatt, H.R. Formation of DNA adducts by 1-hydroxymethylpyrene in liver cells in vivo and in vitro. In: Postlabelling Methods for Detection of DNA Adducts, IARC Scientific Publication No. 124, IARC, Lyon (France), pp 189 - 193 (1993).

 


  48. Glatt, H. R., Pauly, K., Wölfel, C., Dogra, S., Seidel, A., Lee, H., Harvey, R.G., Oesch, F., and Doehmer, J. Stable expression of heterologous cytochromes P450 in V79 cells: mutagenicity studies with polycyclic aromatic hydrocarbons. In: Polycyclic Aromatic Compounds: Synthesis, Properties, Analytical Measurements, Occurrence and Biological Effects (P. Garrigues and M. Lamotte, eds.) Gordon and Breach Science Publishers, Yverdon (Switzerland) pp 1167 - 1174 (1993).

 


  47. Lecoq, S., Platt, K.L., Seidel, A., Oesch, F., Phillips, D.H., and Grover, P.L. Comparisons of the metabolic activation of dibenz[a,h]anthracene and picene using 32P-postlabelling. In: Polycyclic Aromatic Compounds: Synthesis, Properties, Analytical Measurements, Occurrence and Biological Effects (P. Garrigues and M. Lamotte, eds.) Gordon and Breach Science Publishers, Yverdon (Switzerland) pp 921 - 928 (1993).

 


  46. Enders, N., Seidel, A., Monnerjahn, S. and Glatt, H.R. Synthesis of 11 benzylic sulfate esters and their bacterial mutagenicity in dependence of the presence of chloride, bromide and acetate anions. In: Polycyclic Aromatic Compounds: Synthesis, Properties, Analytical Measurements, Occurrence and Biological Effects (P. Garrigues and M. Lamotte, eds.) (Supplement to Polycyclic Aromatic Compounds, Vol. 3), Gordon and Breach Science Publishers, Yverdon (Switzerland) pp 887 - 894 (1993).

 


  45. Glatt, H.R., Wameling, C., Elsberg, S., Thomas, H., Marquardt, H., Hewer, A., Phillips, D.H., Oesch, F., and Seidel, A. "Reverse" diol-epoxides of chrysene: genotoxicity characteristics. In: Polycyclic Aromatic Compounds: Synthesis, Properties, Analytical Measurements, Occurrence and Biological Effects (P. Garrigues and M. Lamotte, eds.) Gordon and Breach Science Publishers, Yverdon (Switzerland) pp 879 - 886 (1993).

 


  44. Johannes, A., Schmoldt, A., Seidel, A., and Glatt, H.R. Sulfate conjugation of various hydroxy-PAH by rat liver sulfotransferases. In: Polycyclic Aromatic Compounds: Synthesis, Properties, Analytical Measurements, Occurrence and Biological Effects (P. Garrigues and M. Lamotte, eds.) Gordon and Breach Science Publishers, Yverdon (Switzerland) pp 703 - 710 (1993).

 


  43. Augustin, C., Schmoldt, A., Glatt, H.R., and Seidel, A. Various UDP-glucuronosyl-transferases involved in regiospecific conjugations of hydroxy-PAH. In: Polycyclic Aromatic Compounds: Synthesis, Properties, Analytical Measurements, Occurrence and Biological Effects (P. Garrigues and M. Lamotte, eds.) Gordon and Breach Science Publishers, Yverdon (Switzerland) pp 687 - 694 (1993).

 


  42. Steinbrecher, T., Wameling, C., Oesch, F., and Seidel, A. Synthesis of polycyclic aromatic hydrocarbon adducts attached to the exocyclic amino group of 2'-deoxyguanosine via nucleophilic substitution. In: Polycyclic Aromatic Compounds: Synthesis, Properties, Analytical Measurements, Occurrence and Biological Effects (P. Garrigues and M. Lamotte, eds.) Gordon and Breach Science Publishers, Yverdon (Switzerland) pp 223 - 230 (1993).

 


  41. Funk, M., Frank, H., Platt, K. L., Oesch, F., and Seidel, A. Synthesis and characterization of glutathione conjugates of diastereomeric bay- and fjord-region dihydrodiol epoxides. In: Polycyclic Aromatic Compounds: Synthesis, Properties, Analytical Measurements, Occurrence and Biological Effects (P. Garrigues and M. Lamotte, eds.) Gordon and Breach Science Publishers, Yverdon (Switzerland) pp 207 - 214 (1993).

 


  40. Wameling, C., Glatt, H.R., Oesch, F., and Seidel, A. Stereospecific synthesis of the diastereomeric "reverse" dihydrodiol epoxides of chrysene and picene. In: Polycyclic Aromatic Compounds: Synthesis, Properties, Analytical Measurements, Occurrence and Biological Effects (P. Garrigues andM. Lamotte, eds.) Gordon and Breach Science Publishers, Yverdon (Switzerland) pp 191 - 198 (1993).

 


  39b Steinbrecher, T., Wameling, C., Oesch, F., and Seidel, A. Activation of the C2 position of purine by the trifluoromethanesulfonate group: synthesis of N2-alkylated deoxy-guanosines. Angew. Chem. Int. Ed. Engl., 32, 404 - 406 (1993).

 


  39a Steinbrecher, T., Wameling, C., Oesch, F., and Seidel, A. Die Trifluormethan- sulfonatfunktion als neue Aktivierung der C-2-Position am Purin: Synthese von N2-alkylierten Deoxyguanosinen. Angew. Chem., 105, 408-410 (1993).

 


  38. Glatt, H.R., Wameling, C., Elsberg S., Thomas H., Marquardt H., Hewer A.,Phillips D.H., Oesch F., and Seidel, A. Genotoxicity characteristics of prebay-region diol-epoxides of chrysene. Carcinogenesis. 14, 11-19 (1993).

 

1992   37. Bock, K.W., Gschaidmeier, H., Seidel, A., S. Baird, and Burchell, B. Mono- and diglucuronide formation of chrysene and benzo[a]pyrene phenols by 3-methylcholanthrene-inducible phenol UDP-glucuronosyltransferase (UGT1A1). Mol. Pharmacol., 42, 613-618 (1992).

 


  36. Jernström, B., Seidel, A., Funk, M., Oesch, F., and Mannervik, B. Glutathione conjugation of trans-3,4-dihydroxy 1,2-epoxy 1,2,3,4-tetrahydrobenzo[c]phenanthrene isomers by human glutathione transferases. Carcinogenesis, 13, 1549-1555 (1992).

 


  35. Wölfel, C., Heinrich-Hirsch, B., Schulz-Schalge, T., Seidel, A., Frank, H., Ramp, U., Wächter, F., Wiebel, F. J., Gonzalez, F., Greim, H., and Doehmer, J. Genetically engineered V79 chinese hamster cells for stable expression of human cytochrome P450IA2. Eur. J. Pharmacol. - Environ. Toxicol. Pharmacol. Sec., 228, 95-102 (1992).

 


  34. Klein, J., Post, K., Seidel, A., Frank, H., Oesch, F., and Platt, K.L. Quinone reduction and redox cycling catalysezed by purified rat liver dihydrodiol/3a-hydroxysteroid dehydrogenase. Biochem. Pharmacol., 44, 341-349 (1992).

 


  33. Doehmer, J., Janssens, C., Dogra, S., Doehmer, C., Seidel, A., Platt, K.-L., Oesch, F., and Glatt, H.R. Application of stable V79 derived cell lines expressing rat cytochromes P450IAI, IA2, and IIB1. Xenobiotica, 22, 1093-1099 (1992).

 


  32. Phillips, D.H., Hewer, A., Seidel, A., Steinbrecher, T., Schrode, R., Oesch, F., and Glatt, H.R. Relationship between mutagenicity and DNA adduct formation in mammalian cells for fjord- and bay-region diol-epoxides of polycyclic aromatic hydrocarbons. Chem.-Biol. Interactions, 80, 177-186 (1992).

 

1991   31. Klein, J., Seidel, A., Frank, H., Oesch, F., and Platt, K.L. Regiospecific oxidation of polycyclic aromatic dihydrodiols by rat liver dihydrodiol dehydrogenase. Chem.-Biol. Interactions, 79, 287-303 (1991).

 


  30. Doehmer, J., Dogra, S., Janssens, C., Edigkaufer, M., Seidel, A., Glatt, H.R., Platt, K.-L., and Oesch, F. Die gentechnologische Konstruktion von V79 Chinesischen Hamsterzellen zur stabilen Expression von Fremdstoff-metabolisierenden Enzymen und ihre Anwendung in Metabolismus- und Mutagenitäts-Studien von Pharmaka und anderen Fremdstoffen. Alternativen zu Tierexperimenten, 8, 52 - 64 (1991).

 


  29. Seidel, A., Bochnitschek, W., Glatt, H.R., Hodgson, R.M., Grover, P.L., and Oesch, F. Activated Metabolites of chrysene: Synthesis of 9-Hydroxychrysene-1,2-diol and the corresponding bay-region syn- and anti-triol-epoxides. In: Polynuclear Aromatic Hydrocarbons: Measurements, Means and Metabolism (ed's. M. Cooke, K. Loening and J. Meritt), Battelle Press, Columbus, OH, pp 801 - 817 (1991).

 


  28. Ludewig, G., Dogra, S., Seidel, A., Setiabudi, F., Oesch, F., and Glatt, H.R. Quinones derived from polycyclic aromatic hydrocarbons: Induction of diverse mutagenic and genotoxic effects in mammalian cells. In: Polynuclear Aromatic Hydrocarbons: Measurements, Means and Metabolism (ed's. M. Cooke, K. Loening and J. Meritt), Battelle Press, Columbus, OH, pp 545 - 556 (1991).

 


  27. Glatt, H.R., Piée A., Pauly K., Steinbrecher, T., Schrode R., Oesch, F. and Seidel, A. Fjord- and bay-region diol-epoxides investigated on stability, SOS induction in Escherichia coli, and mutagenicity in Salmonella typhimurium and mammalian cells. Cancer Res. 51, 1659-1667 (1991). 9.

 


  26. Glatt, H. R., Seidel, A., Schrode, R., Ribeiro, O., Kirkby, C. A., Hirom, P. C., and Oesch, F. 3-Hydroxybenzo[a]pyrene-7,8-dihydrodiol compared with benzo[a]pyrene-7,8-dihydrodiol and 3-hydroxybenzo[a]pyrene with regard to mutagenicity. In: Polynuclear Aromatic Hydrocarbons: Measurements, Means and Metabolism (ed's. M. Cooke, K. Loening and J. Meritt), Battelle Press, Columbus, OH, pp 357 - 368 (1991).

 

1990   25. Hradec, J., Seidel, A., Platt, K.L., Glatt, H.R., Oesch, F., and Koblyakov, V. The Initiator tRNA acceptance assay as a short-term test for carcinogens. 6. Results with 78 polycyclic aromatic compounds. Carcinogenesis, 11, 1921-1926 (1990).

 


  24. Steinberg, P., Schlemper, B., Molitor, E., Platt, K.L., Seidel, A., and Oesch, F. Rat liver Kupffer and endothelial cell-mediated mutagenicity of polycyclic aromatic hydrocarbons and aflatoxin B1. Environ. Health Perspect., 88, 71-76 (1990).

 


  23. Doehmer, J., Seidel, A., Oesch, F., and Glatt, H.R. Genetically-engineered V79 chinese hamster cells metabolically activate the cytostatic drugs cyclophosphamide and ifosfamide. Environ. Health Perspect., 88, 63 - 65 (1990).

 


  22. Glatt, H.R., Henschler, R., Phillips, D. H., Blake, J. W., Steinberg, P., Seidel, A., and Oesch, F. Sulfotransferase-mediated chlorination of 1-hydroxymethylpyrene to a mutagen capable of penetrating into indicator cells. Environ. Health Perspect., 88, 43 - 48 (1990).

 


  21. Masento, M.S., Taylor, G.W., Watson, D., Seidel, A., Bochnitschek, W., Oesch, F., and Grover, P.L. Metabolism of 3-hydroxychrysene by rat liver microsomal preparations. Chem.-Biol. Interactions, 74, 163-178, (1990).

 


  20. Dogra, S., Doehmer, J., Glatt, H.R., Siegert, P., Friedberg, T., Seidel, A., and Oesch, F. Stable expression of rat P450IA1 cDNA in V79 Chinese hamster cells and their use in mutagenicity testing. Mol. Pharmacol., 37, 608-613 (1990).

 


  19. Seidel, A., Glatt, H.R., Oesch, F., and Garrigues, P. 2,9-Dimethylpicene: Synthesis, mutagenic activity, and identification in natural samples. Polycycl. Arom. Compds., 1, 3-14 (1990).

 

1989   18. Knepper T., Lenhardt, S., Przybylski, M., Bosk, C., Platt, K.L., Seidel, A., and Oesch, F. Identification and structural characterization of mono- and bis- glutathionyl conjugates from polyaromatic quinone metabolites. In: Advances in Mass Spectrometry (ed. P. Longevialle), Vol. 11B (Proceedings of the 11th International Mass Spectrometry Conference held at Bordeaux 29. August - 2. September 1988), Heydon & Son, London, pp 1398 - 1399, (1989).

 


  17. Doehmer, J., Dogra, S., Edigkaufer, M., Molitor, E., Siegert, P., Friedberg, T., Glatt, H.R., Platt, K.L., Seidel, A., Thomas, H., and Oesch, F. Introduction of cytochrome P-450 genes into V79 Chinese hamster cells to generate new mutagenicity test systems. Arch. Toxicol., Suppl. 13, 164 - 168, (1989).

 

1988   16. Glatt, H.R., Hirom, P.C., Kirkby, C.A., Ribeiro, O., Seidel, A., and Oesch, F. Complex metabolic activation pathways of polycyclic aromatic hydrocarbons: 3-Hydroxy-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene as a proximate mutagen of 3-hydroxy-benzo[a]pyrene. In: Chemical Carcinogenesis (eds. F. Feo, P. Pani, A. Columbano, and R. Garcea), Plenum Publishing Corporation, New York, pp 37 - 44 (1988).

 


  15. Platt, K.L., Petrovic, P., Seidel, A., Beermann, D., and Oesch, F. Microsomal metabolism of picene. Chem.-Biol. Interactions, 66, 157-175 (1988).

 


  14. Heidmann, M., Fonrobert, P., Przybylski, M., Platt, K.L., Seidel, A., and Oesch, F. Conjugation reactions of polyaromatic quinones to mono- and bisglutathionyl adducts: Direct analysis by fast atom bombardment mass spectrometry. Biomed. Environm. Mass Spectrometry, 15, 329-332 (1988).

 

1987   13.       Hodgson, R.M., Seidel, A., Bochnitschek, W., Glatt, H.R., Oesch, F., and Grover, P. L. Formation of glutathion conjugates from chrysene diol- and triol-epoxides: Evidence for the further metabolism of the “bay-region” diol-epoxide of chrysene to a triol-epoxide. In: Glutathione S -Transferases and Carcinogenesis (eds. T.J. Mantle, C.B. Pickett, and J.D. Hayes), Taylor & Francis, London, pp 239 - 243 (1987).

 


  12.       Glatt, H.R., Seidel, A., Ribeiro, O., Kirkby, C., Hirom, P., and Oesch, F. Metabolic activation to a mutagen of 3-hydroxy-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene, a secondary metabolite of benzo[a]pyrene. Carcinogenesis, 8, 1621-1627 (1987).

 

1986   11. Glatt, H.R., Henschler, R., Klein, J., Ludewig, G., Martiné, U., Pauly, K., Piée, A., Platt, K.L., Seidel, A., Setiabudi, S. and Utesch, D. Multiple activation pathways of both benzene and polycyclic aromatic hydrocarbons leading to products with varying cytotoxic and genotoxic characteristics. In: Primary Changes and Control Factors in Carcinogenesis (eds. T. Friedberg, and F. Oesch) Deutscher Fach-schriften-Verlag, Wiesbaden (Germany), pp 55 - 59 (1986).

 


  10. Hodgson, R. M., Weston, A., Seidel, A., Bochnitschek, W., Glatt, H. R., Oesch, F., and Grover, P. L. Metabolism of chrysene to triols and a triol-epoxide in mouse skin and rat liver preparations. In: Polynuclear Aromatic Hydrocarbons: Chemistry, Characterization and Carcinogenesis (eds. M. Cooke, and A. J. Dennis), Battelle Press, Columbus, OH, pp. 387 - 399 (1986).

 


  9. Glatt, H. R., Seidel, A., Bochnitschek, W., Marquardt, H., Marquardt, H., Hodgson, R. M., Grover, P. L., and Oesch, F. Mutagenicity in bacterial and mammalian cells of diol-epoxides, triol-epoxides and other metabolites of chrysene. In: Polynuclear Aromatic Hydrocarbons: Chemistry, Characterization and Carcinogenesis (eds. M. Cooke , and A. J. Dennis), Battelle Press, Columbus, OH, pp. 343 - 358 (1986).

 


  8. Hodgson, R.M., Seidel, A., Bochnitschek, W., Glatt, H.R., Oesch, F., and Grover, P.L. Metabolism of the bay-region diol-epoxide of chrysene to a triol-epoxide and the enzyme-catalysed conjugation of these epoxides with glutathione. Carcinogenesis, 7, 2095-2098 (1986).

 


  7. Phillips, D.H., Glatt, H.R., Seidel, A., Bochnitschek, W., Oesch, F., and Grover, P.L. Mutagenic potential and DNA adducts formed by diol-epoxides, triol-epoxides and K-region epoxides of chrysene in mammalian cells. Carcinogenesis, 7, 1739-1743 (1986).

 


  6. Glatt, H.R., Seidel, A., Bochnitschek, W., Marquardt, H., Marquardt, H., Hodgson, R.M., Grover, P.L., and Oesch, F. Mutagenic and cell-transforming activities of triol-epoxides as compared to other chrysene metabolites. Cancer Res., 46, 4556-4565 (1986).

 


  5. Wermuth, B., Platt, K. L., Seidel, A., and Oesch, F. Carbonyl reductase provides the enzymatic basis of quinone detoxication in man. Biochem. Pharmacol., 35, 1277-1282 (1986).

 

1985   4. Hodgson, R. M., Seidel, A., Bochnitschek, W., Glatt, H.R., Oesch, F., and Grover, P.L. The formation of 9-hydroxychrysene-1,2-diol as an intermediate in the metabolic activation of chrysene. Carcinogenesis, 6, 135-139 (1985).

 


  3b. Bochnitschek, W., Seidel, A., Kunz, H., and Oesch, F. Reactive metabolites of carcinogenic polycyclic hydrocarbons: Synthesis and trapping reaction of 9-hydroxybenzo[a]pyrene 4,5-oxide. Angew. Chem. Int. Ed. Engl., 24, 699-700 (1985).

 


  3a. Bochnitschek, W., Seidel, A., Kunz, H., and Oesch, F. Reaktive Metabolite cancerogener polycyclischer Kohlenwasserstoffe: Synthese und Abfangreaktion von 9-Hydroxy-benzo[a]pyren-4,5-oxid. Angew. Chem., 97, 703-704 (1985).

 

1984   2.          Oesch, F., Glatt, H. R., Vogel, K., Seidel, A., Petrovic, P., and Platt, K. L. Dihydrodiol dehydrogenase: A new level of control by both sequestration of proximate and inactivation of ultimate carcinogens. In: Biochemical Basis of Chemical Carcinogenesis (eds. H. Greim, R. Jung, M. Kramer, H. Marquardt, and F. Oesch) Raven Press, New York, pp. 23 - 31 (1984).

 


  1.          Beermann, D., Petrovic, P., Seidel, A., and Oesch, F. A facile microsynthesis of 14C-labelled picene. J. Labelled Compds. Radiopharm., 21, 781-787 (1984).
 

About us | Site Map | Impressum | Contact us
 
ISPAC
ISPAC

 

 
Eurotox