2016
Nr. 257Wohak, L.E., Krais, A.M., Kucab, J.E., Stertmann, J., Ovrebo, S., Seidel, A., Phillips, D.H. Arlt, V.M.
Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism.
Arch. Toxicol., 90 (2016) 291-304
Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism.
Arch. Toxicol., 90 (2016) 291-304
Nr. 256Sachse, B., Walter Meinl, W., Sommer, Y., Glatt, H.R., Seidel, A., Monien, B.H.
Bioactivation of suspected food carcinogens 5-hydroxymethylfurfural and furfuryl alcohol by sulfotransferases from human, mouse and rat: a comparative study.
Arch. Toxicol., 90 (2016) 137-148
Bioactivation of suspected food carcinogens 5-hydroxymethylfurfural and furfuryl alcohol by sulfotransferases from human, mouse and rat: a comparative study.
Arch. Toxicol., 90 (2016) 137-148
Nr. 255Krais, A.M., Speksnijder, E.N., Melis, J.P.M., Indra, R., Moserova, M., Godschalk, R.W., van Schooten, F.-J., Seidel, A., Schmeiser, H.H., Stiborova, M., Phillips, D.H., Luijten M., and Arlt, V.M.
The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/-) and Trp53(-/-) mice.
Arch. Toxicol., 90 (2016) 839-851
The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/-) and Trp53(-/-) mice.
Arch. Toxicol., 90 (2016) 839-851
Nr. 254Völkel, W., Kiranoglu, M., Dettbarn, G., Jessel, S., Seidel, A., Fromme, H.
Toxicokinetic of Di-(isononyl)-cyclohexane-1,2-dicarboxylate (DINCH®) in humans following single oral administration.
Tox. Lett., 248 (2016) 16-24
Toxicokinetic of Di-(isononyl)-cyclohexane-1,2-dicarboxylate (DINCH®) in humans following single oral administration.
Tox. Lett., 248 (2016) 16-24
Nr. 253Schreck, I., Grico, N., Hansjosten, I., Marquardt, C., Bormann, S., Seidel, A., Kvietkova, D. L., Pieniazek, D., Segerbäck, D., Diabate, S., van der Horst, G. T., Oesch-Bartlomowicz, B., Oesch, F., Weiss, C.
The nucleotide excision repair protein XPC is essential for bulky DNA adducts to promote interleukin 6 expression via activation of p38-SAPK.
Oncogene, 35 (2016) 908-918
The nucleotide excision repair protein XPC is essential for bulky DNA adducts to promote interleukin 6 expression via activation of p38-SAPK.
Oncogene, 35 (2016) 908-918
2015
Nr. 252Waizenegger, J., Lenze, D., Luckert, C., Seidel, A., Lampen, A., Hessel, S.
Dose-dependent induction of signaling pathways by the flavonoid quercetin in human primary hepatocytes: a transcriptomic study
Mol. Nutr. Food Res, 59 (2015) 1117-1129
Dose-dependent induction of signaling pathways by the flavonoid quercetin in human primary hepatocytes: a transcriptomic study
Mol. Nutr. Food Res, 59 (2015) 1117-1129
Nr. 251Ehlers, A., Florian, S., Schumacher, F., Meinl, H., Lenze, D., Hummel, M., Heise, T., Seidel, A., Glatt, HR., Lampen, A.
The glucosinolate metabolite 1-methoxy-3-indolylmethyl alcohol induces a gene expression profile in mouse liver similar to the expression signature caused by known genotoxic hepatocarcinogens.
Mol. Nutr. Food Res, 59 (2015) 685-697
The glucosinolate metabolite 1-methoxy-3-indolylmethyl alcohol induces a gene expression profile in mouse liver similar to the expression signature caused by known genotoxic hepatocarcinogens.
Mol. Nutr. Food Res, 59 (2015) 685-697
2014
Nr. 250Wohak, L.U.E., Krais, A.M., Kucab, J.E., Stertmann, J., Øvrebø, S., Seidel, A., Phillips, D.H., and Arlt, V.M.
Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53 dependent mechanism.
Arch. Toxicol., 90 (2014) 291-304
Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53 dependent mechanism.
Arch. Toxicol., 90 (2014) 291-304
Nr. 249Kranz, J., Hessel, S., Aretz, J., Seidel, A., Petzinger, E., Geyer, J., Lampen, A.
The role of the efflux carriers Abcg2 and Abcc2 for the hepatobiliary elimination of benzo[a]pyrene and its metabolites in mice.
Chem.-Biol. Interact, 224C (2014) 36-41
The role of the efflux carriers Abcg2 and Abcc2 for the hepatobiliary elimination of benzo[a]pyrene and its metabolites in mice.
Chem.-Biol. Interact, 224C (2014) 36-41
Nr. 248Polanska, K., Dettbarn, G., Jurewicz, J., Sobala, W., Magnus, P., Seidel, A., Hanke, W.
Effect of prenatal polycyclic aromatic hydrocarbons exposure on birth outcomes: the Polish mother and child cohort study.
BioMed Research International, Article ID 408939, 10 pages, open access (2014)
Effect of prenatal polycyclic aromatic hydrocarbons exposure on birth outcomes: the Polish mother and child cohort study.
BioMed Research International, Article ID 408939, 10 pages, open access (2014)
Nr. 247Polanska, K., Hanke, W., Dettbarn, G., Sobala, W., Gromadzinska, J., Magnus, P., Seidel, A.
Exposure of the Polish population to polycyclic aromatic hydrocarbons - a multiple urinary biomarker study among non-smoking pregnant women.
Sci. Total Environ., 487 (2014) 102-109
Exposure of the Polish population to polycyclic aromatic hydrocarbons - a multiple urinary biomarker study among non-smoking pregnant women.
Sci. Total Environ., 487 (2014) 102-109
Nr. 246Westberg, E., Hedebrant, U., Haglund, J., Alsberg, T., Eriksson, J., Seidel, A., Törnqvist, M.
Conditions for sample preparation and HPLC/MS-MS-analysis of bulky adducts to serum albumin with diolepoxides of polycyclic aromatic hydrocarbons as models.
Anal. Bioanal. Chem., 406 (2014) 1519-1530
Conditions for sample preparation and HPLC/MS-MS-analysis of bulky adducts to serum albumin with diolepoxides of polycyclic aromatic hydrocarbons as models.
Anal. Bioanal. Chem., 406 (2014) 1519-1530
Nr. 245Schwarz, M., Behnke, A., Brandt, M., Eisenträger, A., Hassauer, M., Kalberlah, F., Seidel, A.
Semipolar polycyclic aromatic compounds: Identification of 15 priority substances and the need of regulatory steps under reach regulation.
Integr. Environ. Assess. Manag., 10 (2014) 415-428
Semipolar polycyclic aromatic compounds: Identification of 15 priority substances and the need of regulatory steps under reach regulation.
Integr. Environ. Assess. Manag., 10 (2014) 415-428
Nr. 244Schumacher, F., Florian, S., Schnapper, A., Monien, B. H., Mewis, I., Schreiner, M., Seidel, A., Engst, W., Glatt. H.
A secondary metabolite of Brassicales, 1-methoxy-3-indolylmethyl glucosinolate, as well as its degradation product, 1-methoxy-3-indolylmethyl alcohol, forms DNA adducts in the mouse, but in varying tissues and cells.
Arch. Toxicol., 88 (2014) 823-836
A secondary metabolite of Brassicales, 1-methoxy-3-indolylmethyl glucosinolate, as well as its degradation product, 1-methoxy-3-indolylmethyl alcohol, forms DNA adducts in the mouse, but in varying tissues and cells.
Arch. Toxicol., 88 (2014) 823-836
2013
Nr. 243Hessel, S., Stumkat, L., Lampen, A., and Seidel, A.
Polycyclic aromatic hydrocarbons in food - Efflux of the conjugated biomarker 1-hydroxypyrene is mediated by Breast Cancer Resistance Protein (ABCG2) in human intestinal Caco-2 cells.
Food Chem. Toxicol., 62 (2013) 797-804
Polycyclic aromatic hydrocarbons in food - Efflux of the conjugated biomarker 1-hydroxypyrene is mediated by Breast Cancer Resistance Protein (ABCG2) in human intestinal Caco-2 cells.
Food Chem. Toxicol., 62 (2013) 797-804
Nr. 242Seidel, A., Steinberg, P.
Polycyclische aromatische Kohlenwasserstoffe (PAK) in Lebensmitteln – Analytische Methoden und gesetzliche Höchstmengen.
GIT Labor-Fachzeitschrift, 9 (2013) 550-555
Polycyclische aromatische Kohlenwasserstoffe (PAK) in Lebensmitteln – Analytische Methoden und gesetzliche Höchstmengen.
GIT Labor-Fachzeitschrift, 9 (2013) 550-555
Nr. 241Luckert, C., Ehlers, A., Buhrke, T., Seidel, A., Lampen, A., and Hessel, S.
Polycyclic aromatic hydrocarbons stimulate human CYP3A4 promoter activity via PXR.
Toxciol Lett., 222 (2013) 180-188
Polycyclic aromatic hydrocarbons stimulate human CYP3A4 promoter activity via PXR.
Toxciol Lett., 222 (2013) 180-188
Nr. 240Stempin, S., Andres, S., Bumke Scheer, M., Rode, A., Nau, H., Seidel , A., and Lampen, A.
Valproic acid and its derivatives enhanced estrogenic activity but not androgenic activity in a structure dependent manner.
Reprod. Toxicol., 42C (2013) 49-57
Valproic acid and its derivatives enhanced estrogenic activity but not androgenic activity in a structure dependent manner.
Reprod. Toxicol., 42C (2013) 49-57
Nr. 239Seidel, A., Steinberg, P., Appel, K., Lampen, A., H.M. Bolt, und Koss, G.
Kohlenwasserstoffe.
Toxikologie (Marquardt, H., Schäfer, S., und Barth, H., Hrsg.) Wissenschaftliche Verlagsgesellschaft mbH (WVG), Stuttgart (2013) S. 593-659
Kohlenwasserstoffe.
Toxikologie (Marquardt, H., Schäfer, S., und Barth, H., Hrsg.) Wissenschaftliche Verlagsgesellschaft mbH (WVG), Stuttgart (2013) S. 593-659
Nr. 238Seidel, A., Steinberg, P.
Acrolein aus Lebensmitteln – Analytische Erfassung der Humanbelastung.
GIT Labor-Fachzeitschrift, 4 (2013) 231-233
Acrolein aus Lebensmitteln – Analytische Erfassung der Humanbelastung.
GIT Labor-Fachzeitschrift, 4 (2013) 231-233
Nr. 237Nilsson, R., Antić, R., Berni, A., Dallner, G., Dettbarn, G., Gromadzinska, J., Joksić, G., Lundin, C., Palitti, F., Prochazka, G., Rydzynski, K., Segerbäck, D., Souček, P., Michael Tekle, M., and Seidel, A.
Exposure to polycyclic aromatic hydrocarbons in women from Poland, Serbia, and Italy – Relation between PAH metabolite excretion, DNA damage, diet and genotype (the EU DIEPHY project).
Biomarkers, 18 (2013) 165-173
Exposure to polycyclic aromatic hydrocarbons in women from Poland, Serbia, and Italy – Relation between PAH metabolite excretion, DNA damage, diet and genotype (the EU DIEPHY project).
Biomarkers, 18 (2013) 165-173
Nr. 236Hessel, S., John, A., Seidel, A., and Lampen, A.
Multidrug resistance-associated proteins are involved in the transport of the glutathione conjugates of the ultimate carcinogen of benzo[a]pyrene in human Caco-2 cells.
Arch. Toxicol, 87 (2013) 269-280
Multidrug resistance-associated proteins are involved in the transport of the glutathione conjugates of the ultimate carcinogen of benzo[a]pyrene in human Caco-2 cells.
Arch. Toxicol, 87 (2013) 269-280
2012
Nr. 235Schumacher, F., Engst, W., Monien, B.H., Florian, S., Schnapper, A., Steinhauser, L., Albert, K., Frank, H., Seidel, A., and Glatt, H.
Detection of DNA adducts originating from 1-methoxy-3-indolylmethyl glucosinolate using isotope-dilution UPLC-ESI-MS/MS.
Anal. Chem., 84 (2012) 6256-6262
Detection of DNA adducts originating from 1-methoxy-3-indolylmethyl glucosinolate using isotope-dilution UPLC-ESI-MS/MS.
Anal. Chem., 84 (2012) 6256-6262
Nr. 234Monien, B.H., Engst, W., Barknowitz, G., Seidel, A., and Glatt, H.
Mutagenicity of 5-hydroxymethylfurfural in V79 cells expressing human SULT1A1: Identification and mass spectrometric quantification of DNA adducts formed.
Chem. Res. Toxicol., 25 (2012) 1484-1492
Mutagenicity of 5-hydroxymethylfurfural in V79 cells expressing human SULT1A1: Identification and mass spectrometric quantification of DNA adducts formed.
Chem. Res. Toxicol., 25 (2012) 1484-1492
Nr. 233John, A., Hessel, S., Lampen, A., and Seidel, A.
Analysis of GSH conjugates of bay- and fjord-region dihydrodiol epoxides of benzo[a]pyrene and dibenzo[a,l]pyrene and their transport in enterocyte-like Caco-2 cells.
Polycycl. Arom. Compds., 32 (2012) 221-237
Analysis of GSH conjugates of bay- and fjord-region dihydrodiol epoxides of benzo[a]pyrene and dibenzo[a,l]pyrene and their transport in enterocyte-like Caco-2 cells.
Polycycl. Arom. Compds., 32 (2012) 221-237
2011
Nr. 232Roelofzen, J.H., van der Valk, P.G., Godschalk, R., Dettbarn, G., Seidel, A., Golsteijn, L., Anzion, R., Aben, K.K., van Schooten, F.J., Kiemeney, L.A., Scheepers, P.T.
DNA adducts in skin biopsies and 1-hydroxypyrene in urine of psoriasis patients and healthy volunteers following treatment with coal tar.
Toxicol Lett., 213 (2011) 39-44
DNA adducts in skin biopsies and 1-hydroxypyrene in urine of psoriasis patients and healthy volunteers following treatment with coal tar.
Toxicol Lett., 213 (2011) 39-44
Nr. 231Lagerqvist, A., Hakansson, D., Lundin, C., Prochazka, G., Dreij, K., Segerback, D., Jernstrom, B., Tornqvist, M., Frank, H., Seidel, A., Erixon, K. and Jenssen, D.
DNA repair and replication influence the number of mutations per adduct of polycyclic aromatic hydrocarbons in mammalian cells.
DNA Repair (Amst), 10 (2011) 877-886
DNA repair and replication influence the number of mutations per adduct of polycyclic aromatic hydrocarbons in mammalian cells.
DNA Repair (Amst), 10 (2011) 877-886
Nr. 230Schubert, J., Hahn, J., Dettbarn, G., Seidel, A., Luch, A., and Schulz, T.G.
Mainstream Smoke of the Waterpipe: Does This Environmental Matrix Reveal As Significant Source of Toxic Compounds?
Toxicol. Lett., 205 (2011) 275-284
Mainstream Smoke of the Waterpipe: Does This Environmental Matrix Reveal As Significant Source of Toxic Compounds?
Toxicol. Lett., 205 (2011) 275-284
Nr. 229Breuer, D., Hahn, J.-U., Höber, D., Emmel, Ch., Musanke, U., Rühl, R., Spickenheuer, A., Raulf-Heimsoth, M., Bramer, R., Seidel, A., Schilling, B., Heinze, E., Kendzia, B., Marczynski, B., Welge, P., Angerer, J., Brüning, Th., and Pesch, B.
Air sampling and determination of vapours and aerosols of bitumen and polycyclic aromatic hydrocarbons in hot mastic-asphalt applications.
Arch Toxicol, 85 (Suppl 1) (2011) S11-20
Air sampling and determination of vapours and aerosols of bitumen and polycyclic aromatic hydrocarbons in hot mastic-asphalt applications.
Arch Toxicol, 85 (Suppl 1) (2011) S11-20
Nr. 228Lichtenstein, N., Buchwald, K.E., Hennig, M., Bernards, M., Werner, S., Hahn, J.U., Assenmacher-Maiworm, H., Kreyenschmidt, M., Brodkorb, F., Dettbarn, G., Jacob, J., and Seidel, A.
Inhalative Exposition von Dachdeckern gegenüber 2-Naphthylamin und anderen krebserzeugenden aromatischen Aminen bei der Heißverarbeitung von teerhaltigen Klebemassen.
Gefahrstoffe – Reinhaltung der Luft, 71 (2011) 109-207
Inhalative Exposition von Dachdeckern gegenüber 2-Naphthylamin und anderen krebserzeugenden aromatischen Aminen bei der Heißverarbeitung von teerhaltigen Klebemassen.
Gefahrstoffe – Reinhaltung der Luft, 71 (2011) 109-207
Nr. 227Gminski, R., Decker, K., Heinz, C., Seidel, A., Konczol, M., Goldenberg, E., Grobety, B., Ebner, W., Giere, R. and Mersch-Sundermann, V.
Genotoxic effects of three selected black toner powders and their dimethyl sulfoxide extracts in cultured human epithelial A549 lung cells in vitro.
Environ. Mol. Mutagen., 52 (2011) 296-309
Genotoxic effects of three selected black toner powders and their dimethyl sulfoxide extracts in cultured human epithelial A549 lung cells in vitro.
Environ. Mol. Mutagen., 52 (2011) 296-309
Nr. 226Glatt, H., Baasanjav-Gerber, C., Schumacher, F., Monien, B.H., Frank, H., Seidel, A., and Engst, W.
1-Methoxy-3-indolylmethyl glucosinolate: mechanism of bioactivation to genotoxicants for bacteria and mammalian cells.
Chem.-Biol. Interact., 192 (2011) 81-86
1-Methoxy-3-indolylmethyl glucosinolate: mechanism of bioactivation to genotoxicants for bacteria and mammalian cells.
Chem.-Biol. Interact., 192 (2011) 81-86
2010
Nr. 225Seidel, A.
Polyzyklische aromatische Kohlenwasserstoffe. In: ”Sicherheitsrelevante Stoffe in Lebensmitteln - Toxikologie - in der praktischen Qualitätssicherung“ (Steinberg, P. und Hamscher, G., Hrsg.)
Behr’s Verlag (2010) p. 91-117
Polyzyklische aromatische Kohlenwasserstoffe. In: ”Sicherheitsrelevante Stoffe in Lebensmitteln - Toxikologie - in der praktischen Qualitätssicherung“ (Steinberg, P. und Hamscher, G., Hrsg.)
Behr’s Verlag (2010) p. 91-117
Nr. 224Lagerqvist, A., Håkansson, D., Erixon, K., Heinz Frank, Seidel, A., and Jenssen, D.
Structural requirements for mutation formation from polycyclic aromatic hydrocarbon dihydrodiol epoxides in their interaction with food chemopreventive compounds.
Food Chem. Toxicol., 49 (2010) 879-886
Structural requirements for mutation formation from polycyclic aromatic hydrocarbon dihydrodiol epoxides in their interaction with food chemopreventive compounds.
Food Chem. Toxicol., 49 (2010) 879-886
Nr. 223Singh, R., Teichert, F., Seidel, A., Roach, J., Cordell, R., Cheng, M.-K., Frank, H., Steward, W.P., Manson M.M., and Farmer, P.B.
Development of a targeted adductomic method for the determination of polycyclic aromatic hydrocarbon DNA adducts using online column-switching liquid chromatography tandem mass spectrometry.
Rapid Commun. Mass Spectrom. , 24 (2010) 2329–2340
Development of a targeted adductomic method for the determination of polycyclic aromatic hydrocarbon DNA adducts using online column-switching liquid chromatography tandem mass spectrometry.
Rapid Commun. Mass Spectrom. , 24 (2010) 2329–2340
Nr. 222Hessel, S., S., John, A., Seidel, A., Glatt, H., Lampen, A.
Effects of quercetin on the detoxification of the food contaminant benzo[a]pyrene in the human intestinal Caco-2 cell model, in “Risk Assessment of Phytochemicals in Food: Novel Approaches”
Deutsche Forschungsgemeinschaft (DFG) (G. Eisenbrand ed.), Wiley-VCH (2010) p. 404-411
Effects of quercetin on the detoxification of the food contaminant benzo[a]pyrene in the human intestinal Caco-2 cell model, in “Risk Assessment of Phytochemicals in Food: Novel Approaches”
Deutsche Forschungsgemeinschaft (DFG) (G. Eisenbrand ed.), Wiley-VCH (2010) p. 404-411
2009
Nr. 221Hessel, S., John, A., Seidel, A., Lampen, A.
All-trans retinoic acid induces breast cancer resistance protein expression in Caco-2 cells and enhances the transport of benzo[a]pyrene-3-sulfate
Toxicol. Lett., 189 (Suppl.) (2009) S228, F05
All-trans retinoic acid induces breast cancer resistance protein expression in Caco-2 cells and enhances the transport of benzo[a]pyrene-3-sulfate
Toxicol. Lett., 189 (Suppl.) (2009) S228, F05
Nr. 220Eder, C., Frankenberger, M., Stanzel, F., Seidel, A., Schramm, K.-W., Ziegler-Heitbrock, L., and Hofer Th.P.J.
Ultrafine Carbon particles down-regulate CYP1B1 expression in human monocytes.
Part Fibre Toxicol, 6 (2009) 27
Ultrafine Carbon particles down-regulate CYP1B1 expression in human monocytes.
Part Fibre Toxicol, 6 (2009) 27
Nr. 219Monien, B.H., Müller, C., Bakhiya, N., Donath, C., Frank, H., Seidel, A., and Glatt, H.R.
Probenecid, an inhibitor of transmembrane organic anion transporters, alters tissue distribution of DNA adducts in 1-hydroxymethylpyrene-treated rats.
Toxicology., 262 (2009) 80-85
Probenecid, an inhibitor of transmembrane organic anion transporters, alters tissue distribution of DNA adducts in 1-hydroxymethylpyrene-treated rats.
Toxicology., 262 (2009) 80-85
Nr. 218Bakhiya, N., Monien, B., Frank, H., Seidel, A., and Glatt, H.R.
Renal organic anion transporters OAT1 and OAT3 mediate the cellular accumulation of 5-sulfooxymethylfurfural, a reactive, nephrotoxic metabolite of the Maillard product 5-hydroxymethylfurfural.
Biochem. Pharmacol., 78 (2009) 414-419
Renal organic anion transporters OAT1 and OAT3 mediate the cellular accumulation of 5-sulfooxymethylfurfural, a reactive, nephrotoxic metabolite of the Maillard product 5-hydroxymethylfurfural.
Biochem. Pharmacol., 78 (2009) 414-419
Nr. 217Marczynski, B., Pesch, B., Wilhelm, M., Rossbach, B., Preuss, R., Hahn, J.-U., Rabstein, S., Raulf-Heimsoth, M., Seidel, A., Rihs, H.-P., Adams, A., Scherenberg, M., Erkes, A., Engelhardt, B., Straif, K., Käfferlein, H. U., Angerer, J., and Brüning, T.
Occupational Exposure to Polycyclic Aromatic Hydrocarbons and DNA Damage by Industry – A Nationwide Study in Germany.
Arch. Tox., 83 (2009) 947-957
Occupational Exposure to Polycyclic Aromatic Hydrocarbons and DNA Damage by Industry – A Nationwide Study in Germany.
Arch. Tox., 83 (2009) 947-957
Nr. 216Monien, B.H., Frank, H., Seidel, A., and Glatt, H.
Conversion of the common food constituent, 5-hydroxymethylfurfural into a mutagenic and carcinogenic sulfuric acid ester in the mouse in vivo.
Chem Res. Toxicol., 22 (2009) 1123-1128
Conversion of the common food constituent, 5-hydroxymethylfurfural into a mutagenic and carcinogenic sulfuric acid ester in the mouse in vivo.
Chem Res. Toxicol., 22 (2009) 1123-1128
Nr. 215Kuhn, K., Nowak, B., Behnke, A., Seidel, A., and Lampen, A.
Combined chemical and effect-directed analysis of polycyclic aromatic hydrocarbons in smoked pork.
Food Addit Contam., 26 (2009) 1104-1112
Combined chemical and effect-directed analysis of polycyclic aromatic hydrocarbons in smoked pork.
Food Addit Contam., 26 (2009) 1104-1112
Nr. 214Schreck, I., Chudziak, D., Schneider, S., Seidel, A., Platt, K.-L., Oesch, F., and Weiss, C.
Influence of aryl hydrocarbon- (Ah) receptor and genotoxins on DNA repair gene expression and cell survival of mouse hepatoma cells.
Toxicology, 259 (2009) 91-96
Influence of aryl hydrocarbon- (Ah) receptor and genotoxins on DNA repair gene expression and cell survival of mouse hepatoma cells.
Toxicology, 259 (2009) 91-96
Nr. 213Kabler, S.L., Seidel, A., Jacob, J., Doehmer, J., Morrow, C.S., and Townsend, A.J.
Protection by human glutathione S-transferase P1 against cytotoxicity by benzo[a]pyrene or benzo[a]pyrene-7,8-dihydrodiol enantiomers in bi-transgenic cell lines that co-express rat or human cytochrome P4501A1.
Chem.-Biol. Interact., 179 (2009) 240-246
Protection by human glutathione S-transferase P1 against cytotoxicity by benzo[a]pyrene or benzo[a]pyrene-7,8-dihydrodiol enantiomers in bi-transgenic cell lines that co-express rat or human cytochrome P4501A1.
Chem.-Biol. Interact., 179 (2009) 240-246
2008
Nr. 212Yagi, H., Frank, H., Seidel, A., and Jerina, D.M.
Revised assignment of absolute configuration of the cis- and trans-N6-deoxyadenosine adducts at C14 of (±)-11β,12α-dihydroxy-13α,14α-epoxy-11,12,13,14-tetrahydrodibenzo[a,l]pyrene by stereoselective synthesis.
Chem. Res. Toxicol., 21 (2008) 2379-2392
Revised assignment of absolute configuration of the cis- and trans-N6-deoxyadenosine adducts at C14 of (±)-11β,12α-dihydroxy-13α,14α-epoxy-11,12,13,14-tetrahydrodibenzo[a,l]pyrene by stereoselective synthesis.
Chem. Res. Toxicol., 21 (2008) 2379-2392
Nr. 211Monien, B.H., Muller, C., Engst, W., Frank, H., Seidel, A. and Glatt, H.
Time course of hepatic 1-methylpyrene DNA adducts in rats determined by isotope dilution LC-MS/MS and 32P-postlabeling.
Chem. Res. Toxicol., 21 (2008) 2017-2025
Time course of hepatic 1-methylpyrene DNA adducts in rats determined by isotope dilution LC-MS/MS and 32P-postlabeling.
Chem. Res. Toxicol., 21 (2008) 2017-2025
Nr. 210Lagerqvist, A., Håkansson, D., Prochazka, G., Lundin, C., Dreij, K., Segerbäck, D., Jernström, B., Törnqvist, M., Seidel, A., Erixon, K., and Jenssen, D.
Both replication bypass fidelity and repair efficiency influence the yield of mutations per target dose in intact mammalian cells induced by benzo[a]pyrene-diol-epoxide and dibenzo[a,l]pyrene-diol-epoxide.
DNA Repair., 7 (2008) 1202-1212
Both replication bypass fidelity and repair efficiency influence the yield of mutations per target dose in intact mammalian cells induced by benzo[a]pyrene-diol-epoxide and dibenzo[a,l]pyrene-diol-epoxide.
DNA Repair., 7 (2008) 1202-1212
Nr. 209Glatt, H., Rost, K., Frank, H., Seidel, A., and Kollock, R.
Detoxification of promutagenic aldehydes derived from methylpyrenes by human aldehyde dehydrogenases ALDH2 and ALDH3A1.
Arch. Biochem. Biophys., 477 (2008) 196-205
Detoxification of promutagenic aldehydes derived from methylpyrenes by human aldehyde dehydrogenases ALDH2 and ALDH3A1.
Arch. Biochem. Biophys., 477 (2008) 196-205
Nr. 208Kuhn, K., Nowak, N., Klein, G., Behnke, A., Seidel, A., and Lampen, A.
Determination of polycyclic aromatic hydrocarbons in smoked pork by effect directed bioassay with confirmation by chemical analysis.
J. Food Protect., 71 (2008) 993-999
Determination of polycyclic aromatic hydrocarbons in smoked pork by effect directed bioassay with confirmation by chemical analysis.
J. Food Protect., 71 (2008) 993-999
Nr. 207Seidel, A., Spickenheuer, A., Straif, K., Rihs, H.-P., Marczynski, B., Scherenberg, M., Dettbarn, G., Angerer, J., Wilhelm, M., Brüning, T., Jacob, J., and Pesch, B.
New biomarkers of occupational exposure to polycyclic aromatic hydrocarbons.
J. Toxicol. Environ. Health, A 71 (2008) 1–12
New biomarkers of occupational exposure to polycyclic aromatic hydrocarbons.
J. Toxicol. Environ. Health, A 71 (2008) 1–12
Nr. 206Kollock, R., Frank, H., Seidel, A., Meinl, W. and Glatt, H.
Oxidation of alcohols and reduction of aldehydes derived from methyl- and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases.
Toxicology, 245 (2008) 65-75
Oxidation of alcohols and reduction of aldehydes derived from methyl- and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases.
Toxicology, 245 (2008) 65-75
Nr. 205Pääjärvi, G., Jernström, B., Seidel, A., and Stenius U.
Anti-diol epoxide of benzo[a]pyrene induces transient Mdm2 and p53 Ser15 phosphorylation, while anti-diol epoxide of dibenzo[a,l]pyrene induces a nontransient p53 Ser15 phosphorylation.
Mol Carcinog, 47 (2008) 301-309
Anti-diol epoxide of benzo[a]pyrene induces transient Mdm2 and p53 Ser15 phosphorylation, while anti-diol epoxide of dibenzo[a,l]pyrene induces a nontransient p53 Ser15 phosphorylation.
Mol Carcinog, 47 (2008) 301-309
Nr. 204Mattsson, Å., Malmlöf, M, Seidel, A., Stenius, U., Jernström, B.
H2AX, Mdm2 and p53 phosphorylations are differently affected by bay- and fjord-region diol epoxides derived from carcinogenic polycyclic aromatic hydrocarbons.
Polycyclic Aromat. Compd., 28 (2008) 392–401
H2AX, Mdm2 and p53 phosphorylations are differently affected by bay- and fjord-region diol epoxides derived from carcinogenic polycyclic aromatic hydrocarbons.
Polycyclic Aromat. Compd., 28 (2008) 392–401
Nr. 203Kollock, R., Meinl, W., Schneider, H., Batke, M., Frank, H., Seidel, A. and Glatt, H.
Efficient oxidation of promutagenic hydroxymethylpyrenes by cDNA-expressed human alcohol dehydrogenase ADH2 and its inhibition by various agents.
Biochem. Pharmacol., 75 (2008) 527-537
Efficient oxidation of promutagenic hydroxymethylpyrenes by cDNA-expressed human alcohol dehydrogenase ADH2 and its inhibition by various agents.
Biochem. Pharmacol., 75 (2008) 527-537
2007
Nr. 202Pesch, B., Kappler, M., Straif, K., Marczynski, B., Preuss, R., Rossbach, B., Rihs, H.P., Weiss, T., Rabstein, S., Pierl, C., Scherenberg, M., Adams, A., Kafferlein, H.U., Angerer, J., Wilhelm, M., Seidel, A. and Bruning, T.
Dose-response modeling of occupational exposure to polycyclic aromatic hydrocarbons with biomarkers of exposure and effect.
Cancer Epidemiol. Biomarkers Prev., 16 (2007) 1863-1873
Dose-response modeling of occupational exposure to polycyclic aromatic hydrocarbons with biomarkers of exposure and effect.
Cancer Epidemiol. Biomarkers Prev., 16 (2007) 1863-1873
Nr. 201Bakhiya, N., Batke, M., Laake, J., Monien, B.H., Frank, H., Seidel, A., Engst, W. and Glatt, H.
Directing role of organic anion transporters in the excretion of mercapturic acids of alkylated polycyclic aromatic hydrocarbons.
Drug Metab. Dispos., 35 (2007) 1824-1831
Directing role of organic anion transporters in the excretion of mercapturic acids of alkylated polycyclic aromatic hydrocarbons.
Drug Metab. Dispos., 35 (2007) 1824-1831
Nr. 200Halter, R., Hansen, T., Seidel, A., Ziemann, C., and Borlak, J.
Importance of DNA-adduct formation and gene expression profiling of disease candidate genes in rats exposed to bitumen fumes.
J. Occup. Environ. Hyg, 4 (Suppl 1) (2007) 44-64
Importance of DNA-adduct formation and gene expression profiling of disease candidate genes in rats exposed to bitumen fumes.
J. Occup. Environ. Hyg, 4 (Suppl 1) (2007) 44-64
Nr. 199Yagi, H., Frank, H., Seidel, A., and Jerina, D.M.
Synthesis and absolute configuration of cis and trans opened cyclopenta[cd]pyrene 3,4-oxide N2-deoxyguanosine adducts: conversion to phosphoramidites for oligonucleotide synthesis.
Chem. Res. Toxicol., 20 (2007) 650-661
Synthesis and absolute configuration of cis and trans opened cyclopenta[cd]pyrene 3,4-oxide N2-deoxyguanosine adducts: conversion to phosphoramidites for oligonucleotide synthesis.
Chem. Res. Toxicol., 20 (2007) 650-661
Nr. 198Hansen, T., Seidel, A., and Borlak, J.
The environmental carcinogen 3-nitrobenzanthrone and its main metabolite 3-aminobenzanthrone induce production of reactive oxygen intermediates in human epithelial lung cells.
Toxicol Appl Pharmacol, 221 (2007) 222-234
The environmental carcinogen 3-nitrobenzanthrone and its main metabolite 3-aminobenzanthrone induce production of reactive oxygen intermediates in human epithelial lung cells.
Toxicol Appl Pharmacol, 221 (2007) 222-234
Nr. 197Glatt, H.R., Schneider, H., Seidel, A.
Polycyclische aromatische Kohlenwasserstoffe.
Handbuch der Lebensmitteltoxikologie (H. Dunkelberg, T. Gebel, A. Hartwig, eds.), Wiley-VCH Verlag, Weinheim (2007) 1121-1155
Polycyclische aromatische Kohlenwasserstoffe.
Handbuch der Lebensmitteltoxikologie (H. Dunkelberg, T. Gebel, A. Hartwig, eds.), Wiley-VCH Verlag, Weinheim (2007) 1121-1155
Nr. 196Ebert, B., Seidel, A., and Lampen, A.
Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate.
Toxicol. Sci., 96 (2007) 227-236
Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate.
Toxicol. Sci., 96 (2007) 227-236
Nr. 195Rihs, H.-P., John, A., Scherenberg, M., Seidel, A., and Brüning, T.
Concordance between the deduced acetylation status generated by Real-time PCR based NAT2 genotyping of seven single nucleotide polymorphisms and human NAT2 phenotypes determined with caffeine.
Clinica Chim. Acta, 376 (2007) 240-243
Concordance between the deduced acetylation status generated by Real-time PCR based NAT2 genotyping of seven single nucleotide polymorphisms and human NAT2 phenotypes determined with caffeine.
Clinica Chim. Acta, 376 (2007) 240-243
2006
Nr. 194Simon, R., Palme, S., Anklam E. and Collaborators: L. Delaire; V. Hanot; H. Holzer; W. Jira; C. Levasseur; F. Monteau; M.W. Obiedzinski; M. Ojala; D. Peschke; S. Ramakrishnan; C. Ranta; A. Ruthenschrör; M. Schirmacher; A. Seidel; P. Sopelana; G. Wolz; and C. Wright
Method Validation for Determination of the 15 European-Priority Polycyclic Aromatic Hydrocarbons in Primary Smoke Condensates by Gas Chromatography/Mass Spectrometry: Interlaboratory Study.
Journal of AOAC International, 89 (2006) 772-781
Method Validation for Determination of the 15 European-Priority Polycyclic Aromatic Hydrocarbons in Primary Smoke Condensates by Gas Chromatography/Mass Spectrometry: Interlaboratory Study.
Journal of AOAC International, 89 (2006) 772-781
Nr. 193Wang, B., Sayer, J.M., Yagi, H., Frank, H., Seidel, A., and Jerina, D.M.
Facile interstrand migration of the hydrocarbon moiety of a dibenzo[a,l]pyrene 11,12-diol 13,14-epoxide adduct at N2 of deoxyguanosine in a duplex oligonucleotide.
J. Am. Chem. Soc., 128 (2006) 10079-10084
Facile interstrand migration of the hydrocarbon moiety of a dibenzo[a,l]pyrene 11,12-diol 13,14-epoxide adduct at N2 of deoxyguanosine in a duplex oligonucleotide.
J. Am. Chem. Soc., 128 (2006) 10079-10084
Nr. 192Schober, W., Luch, A., Soballa, V.J., Raab, G., Stegeman, J.J., Doehmer, J., Jacob, J. and Seidel, A.
On the species-specific biotransformation of dibenzo[a,l]pyrene.
Chem. Biol. Interact., 161 (2006) 37-48
On the species-specific biotransformation of dibenzo[a,l]pyrene.
Chem. Biol. Interact., 161 (2006) 37-48
Nr. 191Bakhiya, N., Stephani, M., Seidel, A., Bahn, A., Ugele, B., Burckhardt, G. and Glatt, H.R.
Uptake of chemically reactive, DNA-damaging sulfuric acid esters into renal cells by human organic anion transporters.
J. Am. Soc. Nephrol., 17 (2006) 1414-1421
Uptake of chemically reactive, DNA-damaging sulfuric acid esters into renal cells by human organic anion transporters.
J. Am. Soc. Nephrol., 17 (2006) 1414-1421
2005
Nr. 190van Lipzig, M.M.H., Vermeulen, N.P.E., Gusino, R., Legler, J., Frank, H., Seidel. A. and Meerman, J.H.N.
Formation of estrogenic metabolites of benzo[a]pyrene and chrysene by cytochrome P450 activity and their combined and supra-maximal estrogenic activity.
Environ. Toxicol. Pharmacol., 19 (2005) 41-55
Formation of estrogenic metabolites of benzo[a]pyrene and chrysene by cytochrome P450 activity and their combined and supra-maximal estrogenic activity.
Environ. Toxicol. Pharmacol., 19 (2005) 41-55
Nr. 189Musafija-Jeknic, T., Luch, A., Seidel, A., Johns, C., Pereira, C., and Baird, W.M.
Effect of nucleotide sequence on the binding of (–)-anti-dibenzo[a,l]pyrene-11,12-diol 13,14-epoxide to short oligodeoxyribonucleotides.
Polycycl. Aromat. Compds., 25 (2005) 103-111
Effect of nucleotide sequence on the binding of (–)-anti-dibenzo[a,l]pyrene-11,12-diol 13,14-epoxide to short oligodeoxyribonucleotides.
Polycycl. Aromat. Compds., 25 (2005) 103-111
Nr. 188Seidel, A.
Biomonitoring of PAHs - Human Exposure, in “The carcinogenic effects of polycyclic aromatic hydrocarbons” (Luch, A., ed.)
Imperial College Press (ICP), London (UK) (2005) p 97-136
Biomonitoring of PAHs - Human Exposure, in “The carcinogenic effects of polycyclic aromatic hydrocarbons” (Luch, A., ed.)
Imperial College Press (ICP), London (UK) (2005) p 97-136
Nr. 187Ebert, B., Seidel, A., and Lampen, A.
Identification of BCRP as transporter of benzo[a]-pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists.
Carcinogenesis, 26 (2005) 1754-1763
Identification of BCRP as transporter of benzo[a]-pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists.
Carcinogenesis, 26 (2005) 1754-1763
Nr. 186Ebert, B., Jacob, J., Seidel, A., and Lampen, A.
Oltipraz, flavone and indole-3-carbinol enhance the formation and transport of sulfate conjugates of benzo[a]pyrene in human enterocytes.
Tox. Lett., 157 (2005) 140-151
Oltipraz, flavone and indole-3-carbinol enhance the formation and transport of sulfate conjugates of benzo[a]pyrene in human enterocytes.
Tox. Lett., 157 (2005) 140-151
Nr. 185Mensing, T., Marczynski, B., Engelhardt, B., Wilhelm, M., Preuss, R., Kappler, M., Angerer, J., Käfferlein, H.U., Scherenberg, M., Seidel, A., Brüning, T.
DNA adduct formation of benzo[a]pyrene in white blood cells of workers exposed to polycyclic aromatic hydrocarbons.
Int. J. Hyg. Environ. Health., 208 (2005) 173-178
DNA adduct formation of benzo[a]pyrene in white blood cells of workers exposed to polycyclic aromatic hydrocarbons.
Int. J. Hyg. Environ. Health., 208 (2005) 173-178
Nr. 184Rihs, H.-P., Pesch, B., Kappler, M., Rabstein, S., Roßbach, B., Angerer, J., Scherenberg, M., Adams, A., Wilhelm, M., Seidel, A., and Brüning, T.
Occupational exposure to polycyclic aromatic hydrocarbons in German industries: Association between ambient exposure and urinary metabolites and its modulation by enzyme polymorphisms.
Tox. Lett., 157 (2005) 241-255
Occupational exposure to polycyclic aromatic hydrocarbons in German industries: Association between ambient exposure and urinary metabolites and its modulation by enzyme polymorphisms.
Tox. Lett., 157 (2005) 241-255
Nr. 183Dreij, K., Seidel, A., and Jernström, J.
Differential removal of DNA-adducts derived from anti-diol epoxides of dibenzo[a,l]pyrene and benzo[a]pyrene in human cells.
Chem Res. Toxicol., 18 (2005) 655-664
Differential removal of DNA-adducts derived from anti-diol epoxides of dibenzo[a,l]pyrene and benzo[a]pyrene in human cells.
Chem Res. Toxicol., 18 (2005) 655-664
Nr. 182Marczynski, B., Preuss, R., Mensing, T., Angerer, J., Seidel, A., El Mourabit, A., Wilhelm, M., and Brüning, T.
Genotoxic risk assessment in white blood cells of occupationally exposed workers before and after alteration of the polycyclic aromatic hydrocarbon (PAH) profile in the production material: comparison with PAH air and urinary metabolite levels.
Int Arch Occup Environ Health, 78 (2005) 98-108
Genotoxic risk assessment in white blood cells of occupationally exposed workers before and after alteration of the polycyclic aromatic hydrocarbon (PAH) profile in the production material: comparison with PAH air and urinary metabolite levels.
Int Arch Occup Environ Health, 78 (2005) 98-108
2004
Nr. 181Angerer, J., Roßbach, B., und Seidel, A.
Bestandsaufnahme zur Frage des Zusammenhangs zwischen dem DNA-Adduktgehalt in weißen Blutzellen und in humanem Lungengewebe.
Poly-cyclische aromatische Kohlenwasserstoffe – DFG Forschungsbericht (Jacob, J., und Greim, H., Hrsg.) WILEY-VCH Verlag GmbH & Co KGaA, (Weinheim) (2004) S. 77-117
Bestandsaufnahme zur Frage des Zusammenhangs zwischen dem DNA-Adduktgehalt in weißen Blutzellen und in humanem Lungengewebe.
Poly-cyclische aromatische Kohlenwasserstoffe – DFG Forschungsbericht (Jacob, J., und Greim, H., Hrsg.) WILEY-VCH Verlag GmbH & Co KGaA, (Weinheim) (2004) S. 77-117
Nr. 180Seidel, A., Angerer, J.
Nukleobasen-Addukte von PAH im Humanurin.
Poly-cyclische aromatische Kohlenwasserstoffe – DFG Forschungsbericht (Jacob, J., und Greim, H., Hrsg.) WILEY-VCH Verlag GmbH & Co KGaA, (Weinheim) (2004) S. 70-76
Nukleobasen-Addukte von PAH im Humanurin.
Poly-cyclische aromatische Kohlenwasserstoffe – DFG Forschungsbericht (Jacob, J., und Greim, H., Hrsg.) WILEY-VCH Verlag GmbH & Co KGaA, (Weinheim) (2004) S. 70-76
Nr. 179Jacob, J., Seidel, A.
Biomonitoring von PAH-Metaboliten im Humanurin.
Polycyclische aromatische Kohlenwasserstoffe – DFG Forschungsbericht (Jacob, J., und Greim, H., Hrsg.) WILEY-VCH Verlag GmbH & Co KGaA, (Weinheim) (2004) S. 42-69
Biomonitoring von PAH-Metaboliten im Humanurin.
Polycyclische aromatische Kohlenwasserstoffe – DFG Forschungsbericht (Jacob, J., und Greim, H., Hrsg.) WILEY-VCH Verlag GmbH & Co KGaA, (Weinheim) (2004) S. 42-69
Nr. 178Jacob, J., Seidel, A.
Verwendung eines auf Wirkungsäquivalenten basierenden Summenparameters für die Abschätzung der PAH-Exposition und ihres Krebs erregenden Potentials.
Polycyclische aromatische Kohlenwasserstoffe – DFG Forschungsbericht (Jacob, J., und Greim, H., Hrsg.) WILEY-VCH Verlag GmbH & Co KGaA, (Weinheim) (2004) S. 8-22
Verwendung eines auf Wirkungsäquivalenten basierenden Summenparameters für die Abschätzung der PAH-Exposition und ihres Krebs erregenden Potentials.
Polycyclische aromatische Kohlenwasserstoffe – DFG Forschungsbericht (Jacob, J., und Greim, H., Hrsg.) WILEY-VCH Verlag GmbH & Co KGaA, (Weinheim) (2004) S. 8-22
Nr. 177Seidel, A., Frank, H., Behnke, A., Schneider, D., and Jacob, J.
Determination of dibenzo[a,l]pyrene and other fjord-region PAH isomers with mw 302 in environmental samples.
Polycycl. Aromat. Compds., 24 (2004) 759-771
Determination of dibenzo[a,l]pyrene and other fjord-region PAH isomers with mw 302 in environmental samples.
Polycycl. Aromat. Compds., 24 (2004) 759-771
Nr. 176Dreij, K., Bajak E., Sundberg K., Cotgreave I., Jernström. B., Seidel, A. and Gusnanto A.
DNA adducts of benzo[a]pyrene- and dibenzo[a,l]pyrene-diol epoxides in human lung epithelial cells: kinetics of adduct removal, effects on cell cycle checkpoints, and gene expression.
Polycycl. Aromat. Compds., 24 (2004) 549-566
DNA adducts of benzo[a]pyrene- and dibenzo[a,l]pyrene-diol epoxides in human lung epithelial cells: kinetics of adduct removal, effects on cell cycle checkpoints, and gene expression.
Polycycl. Aromat. Compds., 24 (2004) 549-566
Nr. 175Päärjävi, G., Jernström. B., Stenius, U., and Seidel, A.
Exposure of mammalian cells to diol epoxides from benzo[a]pyrene and dibenzo[a,l]pyrene and effects on Mdm2 and p53.
Polycycl. Aromat. Compds., 24 (2004) 537-548
Exposure of mammalian cells to diol epoxides from benzo[a]pyrene and dibenzo[a,l]pyrene and effects on Mdm2 and p53.
Polycycl. Aromat. Compds., 24 (2004) 537-548
Nr. 174Lampen, A., Ebert, B., Stumkat, L., Jacob, J., and Seidel, A.
Induction of gene expression of xenobiotic metabolism enzymes and ABC-transport proteins by PAH and a reconstituted PAH mixture in human Caco-2 cells.
Biochim. Biophys. Acta, 1681 (2004) 38-46
Induction of gene expression of xenobiotic metabolism enzymes and ABC-transport proteins by PAH and a reconstituted PAH mixture in human Caco-2 cells.
Biochim. Biophys. Acta, 1681 (2004) 38-46
2003
Nr. 173Wu, J., Wu, J., Zhu, B.B., Yu, J., Zhu, H., Qiu, L., Kindy, M.S., Gu, L., Seidel, A., Li, G.M.
In vitro and in vivo modulations of benzo[c]phenanthrene-DNA adducts by DNA mismatch repair system.
Nucleic Acids Res., 31 (2003) 6428-6434
In vitro and in vivo modulations of benzo[c]phenanthrene-DNA adducts by DNA mismatch repair system.
Nucleic Acids Res., 31 (2003) 6428-6434
Nr. 172Arlt, V.M., Glatt, H.R., Muckel, E., Pabel, U., Sorg, B.L., Seidel, A., Frank, H., Schmeiser, H.H., and Phillips, D.H.
Activation of 3-nitrobenzanthrone and its metabolites by human acetyltransferases, sulfotransferases and cytochrome P450 expressed in Chinese hamster V79 cells.
Int. J. Cancer, 105 (2003) 583-592
Activation of 3-nitrobenzanthrone and its metabolites by human acetyltransferases, sulfotransferases and cytochrome P450 expressed in Chinese hamster V79 cells.
Int. J. Cancer, 105 (2003) 583-592
Nr. 171Mahadevan, B., Dashwood, W.-M., Luch, A., Pecaj, A., Doehmer, J., Seidel, A., and Baird, W.M.
Mutations induced by (–)-anti-11R,12S-dihydrodiol 13S,14R-epoxide of dibenzo[a,l]pyrene in the coding region of the hypoxanthine phosphoribosyltransferase (hprt) gene in Chinese hamster V79 cells.
Environ. Mol. Mutagen., 41 (2003) 131-139
Mutations induced by (–)-anti-11R,12S-dihydrodiol 13S,14R-epoxide of dibenzo[a,l]pyrene in the coding region of the hypoxanthine phosphoribosyltransferase (hprt) gene in Chinese hamster V79 cells.
Environ. Mol. Mutagen., 41 (2003) 131-139
Nr. 170Arlt V.M., Bernd L. Sorg, B.L., Osborne, M., Hewer, A., Seidel, A., Schmeiser, H.H., and Phillips, D.H.
DNA adduct formation by the ubiquitous environmental pollutant 3-nitro-benzanthrone and its metabolites in rats.
Biochem. Biophys. Res. Commun., 300 (2003) 107-114
DNA adduct formation by the ubiquitous environmental pollutant 3-nitro-benzanthrone and its metabolites in rats.
Biochem. Biophys. Res. Commun., 300 (2003) 107-114
Nr. 169Buesen, R., Mock, M., Nau, H., Seidel, A., Jacob, J., and Lampen, A.
Evidence for an active transport of polar [14C]-benzo[a]pyrene metabolites in human intestinal Caco-2 cells.
Chem.-biol. Interact., 142 (2003) 201-344
Evidence for an active transport of polar [14C]-benzo[a]pyrene metabolites in human intestinal Caco-2 cells.
Chem.-biol. Interact., 142 (2003) 201-344
2002
Nr. 168Buesen, R., Mock, M., Seidel, A., Jacob, J., and Lampen, A.
Interaction between metabolism and transport of benzo[a]pyrene and its metabolites in enterocytes.
Toxicol. Appl. Pharmacol., 183 (2002) 168-178
Interaction between metabolism and transport of benzo[a]pyrene and its metabolites in enterocytes.
Toxicol. Appl. Pharmacol., 183 (2002) 168-178
Nr. 167Sundberg, K., Dreij, K., Jernström, B. and Seidel, A.
Detoxification of polycyclic aromatic hydrocarbon diol epoxides by human glutathione transferases: efficiency of conjugation in intact cells relative to purified enzymes.
Polycycl. Aromat. Compds., 22 (2002) 947-953
Detoxification of polycyclic aromatic hydrocarbon diol epoxides by human glutathione transferases: efficiency of conjugation in intact cells relative to purified enzymes.
Polycycl. Aromat. Compds., 22 (2002) 947-953
Nr. 166Dreij, K., Sundberg, K., Jernström, B., Johansson, A.-S., Mannervik, B., and Seidel, A.
Inactivation of carcinogenic diol epoxides of dibenzo[a,l]pyrene (dibenzo[def,p]chrysene by human alpha class glutathione transferases.
Polycycl. Aromat. Compds., 22 (2002) 823-829
Inactivation of carcinogenic diol epoxides of dibenzo[a,l]pyrene (dibenzo[def,p]chrysene by human alpha class glutathione transferases.
Polycycl. Aromat. Compds., 22 (2002) 823-829
Nr. 165Luch, A., Greim, H., Buters, J.T.M., Mahadevan, B., Baird, W.M., Doehmer, J., Seidel, A., and Glatt, H.R.
The role of cytochrome P450 1B1 in dibenzo[a,l]pyrene-induced carcinogenesis.
Polycycl. Aromat. Compds., 22 (2002) 781-789
The role of cytochrome P450 1B1 in dibenzo[a,l]pyrene-induced carcinogenesis.
Polycycl. Aromat. Compds., 22 (2002) 781-789
Nr. 164Baird, W.M., Hooven, L.A., Mahadevan, B., Luch, A., Seidel, A., Iversen, P.L.
Responses of human cells to PAH-induced DNA damage.
Polycycl. Aromat. Compds., 22 (2002) 771-780
Responses of human cells to PAH-induced DNA damage.
Polycycl. Aromat. Compds., 22 (2002) 771-780
Nr. 163Jacob, J., Seidel, A.
Biomonitoring of polycyclic aromatic hydrocarbons (review)
J. Chromatogr. B, 778 (2002) 31-47
Biomonitoring of polycyclic aromatic hydrocarbons (review)
J. Chromatogr. B, 778 (2002) 31-47
Nr. 162Dreij, K., Sundberg, K., Johansson, A.-S., Nordling, E., Seidel, A., Persson, E., Mannervik, B., and Jernström, B.
Catalytic activities of human alpha class glutathione transferases towards carcinogenic dibenzo[a,l]pyrene diol epoxides.
Chem. Res. Toxicol., 15 (2002) 825-831
Catalytic activities of human alpha class glutathione transferases towards carcinogenic dibenzo[a,l]pyrene diol epoxides.
Chem. Res. Toxicol., 15 (2002) 825-831
Nr. 161Jacob, J., Seidel, A.
Zur Problematik der Verwendung von Benzo[a]pyren als Leitkomponente für das PAH-bedingte karzinogene Potential in Umweltmatrices
Gefahrstoffe - Reinhaltung der Luft, 62 (2002) 239-246
Zur Problematik der Verwendung von Benzo[a]pyren als Leitkomponente für das PAH-bedingte karzinogene Potential in Umweltmatrices
Gefahrstoffe - Reinhaltung der Luft, 62 (2002) 239-246
Nr. 160Platt, K.-L., Degenhardt, C., Grupe, S., Frank, H., and Seidel, A.
Microsomal activation of anthanthrene, a hexacyclic aromatic hydrocarbon without a bay-region, to mutagenic metabolites.
Chem. Res. Toxicol., 15 (2002) 332-342
Microsomal activation of anthanthrene, a hexacyclic aromatic hydrocarbon without a bay-region, to mutagenic metabolites.
Chem. Res. Toxicol., 15 (2002) 332-342
Nr. 159Seidel, A., Dahmann, D., Krekeler, H., and Jacob, J.
Biomonitoring of polycyclic aromatic compounds in the urine of mining workers occupationally exposed to diesel-exhaust.
Inter. J. Hyg. Environ. Health, 204 (2002) 333-338
Biomonitoring of polycyclic aromatic compounds in the urine of mining workers occupationally exposed to diesel-exhaust.
Inter. J. Hyg. Environ. Health, 204 (2002) 333-338
Nr. 158Sundberg, K., Dreij, K., Seidel, A., and Jernström, B.
Glutathione conjugation and DNA adduct formation of dibenzo[a,l]pyrene and benzo[a]pyrene diol epoxides in V79 cells stably expressing different human glutathione transferases.
Chem. Res. Toxicol., 15 (2002) 170-179
Glutathione conjugation and DNA adduct formation of dibenzo[a,l]pyrene and benzo[a]pyrene diol epoxides in V79 cells stably expressing different human glutathione transferases.
Chem. Res. Toxicol., 15 (2002) 170-179
Nr. 157Schwerdtle, T., Seidel, A., and Hartwig, A.
Effect of soluble particulate nickel compounds on the formation and repair of stable benzo[a]pyrene DNA adducts in human lung cells.
Carcinogenesis, 23 (2002) 47-53
Effect of soluble particulate nickel compounds on the formation and repair of stable benzo[a]pyrene DNA adducts in human lung cells.
Carcinogenesis, 23 (2002) 47-53
2001
Nr. 156Seidel, A., Grimmer, G., Dettbarn, G., and Jacob, J.
Nachweis von kanzerogenen aromatischen Aminen im Harn von Nichtrauchern.
Umweltmed. Forsch. Prax., 6 (2001) 213-220
Nachweis von kanzerogenen aromatischen Aminen im Harn von Nichtrauchern.
Umweltmed. Forsch. Prax., 6 (2001) 213-220
Nr. 155Mahadevan, B., Luch, A., Seidel, A., Pelling, J.C., and Baird, W.M.
Effects of (–)-anti-11R,12S-dihydrodiol 13S,14R-epoxide of dibenzo[a,l]pyrene on DNA adduct formation and cell cycle arrest in human diploid fibroblasts.
Carcinogenesis, 22 (2001) 161-169
Effects of (–)-anti-11R,12S-dihydrodiol 13S,14R-epoxide of dibenzo[a,l]pyrene on DNA adduct formation and cell cycle arrest in human diploid fibroblasts.
Carcinogenesis, 22 (2001) 161-169
2000
Nr. 154Ma, L., Landsiedel, R., Seidel, A., and Glatt, H.R.
Detection of mercapturic acids and nucleoside adducts in blood, urine and faeces of rats treated with 1-hydroxy-methylpyrene.
Polycycl. Arom. Compds., 21 (2000) 135-149
Detection of mercapturic acids and nucleoside adducts in blood, urine and faeces of rats treated with 1-hydroxy-methylpyrene.
Polycycl. Arom. Compds., 21 (2000) 135-149
Nr. 153Sundberg, K., Townsend, A., Luch, A., Seidel, A., and Jernström, B.
Effect of glutathione transferases on DNA-adduct formation of polycyclic aromatic hydrocarbons in mammalian cells.
Polycycl. Arom. Compds., 21 (2000) 123-133
Effect of glutathione transferases on DNA-adduct formation of polycyclic aromatic hydrocarbons in mammalian cells.
Polycycl. Arom. Compds., 21 (2000) 123-133
Nr. 152Jacob, J., Schober, W., Raab, G., Frank, H., Luch, A., Doehmer, J., and Seidel, A.
Species dependent metabolism of benzo[c]chrysene mediated by c-DNA-expressed human, rodent and fish cytochrome P450 enzymes.
Polycycl. Arom. Compds., 21 (2000) 109-121
Species dependent metabolism of benzo[c]chrysene mediated by c-DNA-expressed human, rodent and fish cytochrome P450 enzymes.
Polycycl. Arom. Compds., 21 (2000) 109-121
Nr. 151Luch, A., Schober, W., Greim, H., Doehmer, J., Jacob, J., Seidel, A., and Baird, W.M.
Metabolic activation of dibenzo[a,l]pyrene by cytochrome P450 enzymes to stable DNA adducts occurs exclusively through the formation of the (–)-trans-(11R,12R)-dihydrodiol.
Polycycl. Arom. Compds., 21 (2000) 87-98
Metabolic activation of dibenzo[a,l]pyrene by cytochrome P450 enzymes to stable DNA adducts occurs exclusively through the formation of the (–)-trans-(11R,12R)-dihydrodiol.
Polycycl. Arom. Compds., 21 (2000) 87-98
Nr. 150Borlak, J., Hansen, T., Yuan, X.Y., Sikka, H.C., Kumar, S., Schmidbauer, S., Raab, G., Frank, H., Jacob, J., and Seidel, A.
Metabolism and DNA binding of 3-nitrobenzanthrone in human fetal bronchial epithelial and alveolar typ II cells.
Polycycl. Arom. Compds., 21 (2000) 73-86
Metabolism and DNA binding of 3-nitrobenzanthrone in human fetal bronchial epithelial and alveolar typ II cells.
Polycycl. Arom. Compds., 21 (2000) 73-86
Nr. 149Kroth, H., Yagi, H., Seidel, A., and Jerina, D.M.
New and highly efficient synthesis of cis- and trans-opened benzo[a]pyrene 7,8-diol 9,10-epoxide adducts at the exocyclic amino group of deoxyguanosine.
J. Org. Chem., 65 (2000) 5558-5564
New and highly efficient synthesis of cis- and trans-opened benzo[a]pyrene 7,8-diol 9,10-epoxide adducts at the exocyclic amino group of deoxyguanosine.
J. Org. Chem., 65 (2000) 5558-5564
Nr. 148Doehmer, J., Krebsfänger, N., Schober, W., Luch, A., Buters, J.T.M., Jacob, J., Seidel, A., Mürdter, T., Zanger, U.M., and Eichelbaum, M.
Building a bio-technology platform for metabolism studies in pharmacology and toxicology.
Progress in the Reduction, Refinement and Replacement of Animal Experimentation, (Balls, M., van Zeller, A.-M., and Halder, M.E., ed's), Elsevier Science B.V. (2000) pp 139-146
Building a bio-technology platform for metabolism studies in pharmacology and toxicology.
Progress in the Reduction, Refinement and Replacement of Animal Experimentation, (Balls, M., van Zeller, A.-M., and Halder, M.E., ed's), Elsevier Science B.V. (2000) pp 139-146
Nr. 147Buterin, T., Hess, M.T., Luneva, N., Geacintov, N.E., Amin, S., Kroth, H., Seidel, A., and Naegeli, H.
Unrepaired fjord region polycyclic aromatic hydrocarbon-DNA adducts in ras codon 61 mutational hot spots
Cancer Res., 60 (2000) 1849-1856
Unrepaired fjord region polycyclic aromatic hydrocarbon-DNA adducts in ras codon 61 mutational hot spots
Cancer Res., 60 (2000) 1849-1856
Nr. 146Li, D.N., Seidel, A., Pritchard, M.P., Wolf, C.R., and Friedberg, T.
Polymorphisms in P450 CYP1B1 affect the conversion of estradiol to the potentially carcinogenic metabolite 4-hydroxyestradiol.
Pharmacogenetics, 10 (2000) 343-353
Polymorphisms in P450 CYP1B1 affect the conversion of estradiol to the potentially carcinogenic metabolite 4-hydroxyestradiol.
Pharmacogenetics, 10 (2000) 343-353
Nr. 145Grimmer, G., Dettbarn, G., Seidel, A., and Jacob, J.
Detection of carcinogenic aromatic amines in the urine of non-smokers.
Sci. Total Environ., 247 (2000) 81-90
Detection of carcinogenic aromatic amines in the urine of non-smokers.
Sci. Total Environ., 247 (2000) 81-90
Nr. 144Melendez-Colon, V.J., Luch, A., Seidel, A., and Baird, W.M.
Formation of stable DNA adducts and apurinic sites upon metabolic activation of bay and fjord region polycyclic aromatic hydrocarbons in human cell cultures.
Chem. Res. Toxicol., 13 (2000) 10-17
Formation of stable DNA adducts and apurinic sites upon metabolic activation of bay and fjord region polycyclic aromatic hydrocarbons in human cell cultures.
Chem. Res. Toxicol., 13 (2000) 10-17
1999
Nr. 143Sundberg, K., Seidel, A., Mannervik, B., and Jernström, B.
Catalytic efficiency of glutathione transferase P1-1 variants towards bay- and fjord-region diol epoxides of polycyclic aromatic hydrocarbons.
Polycycl. Aromat. Compds., 17 (1999) 43-51
Catalytic efficiency of glutathione transferase P1-1 variants towards bay- and fjord-region diol epoxides of polycyclic aromatic hydrocarbons.
Polycycl. Aromat. Compds., 17 (1999) 43-51
Nr. 142Pradhan, P., Gräslund, A., Seidel, A., and Jernström, B.
Studies on adduct formation of (+)-anti-benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide with the oligonucleotides 5'-d(CCTA TCGTTATCC) and 5'-d(CCTATCm5GTTATCC).
Polycycl. Aromat. Compds., 17 (1999) 21-32
Studies on adduct formation of (+)-anti-benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide with the oligonucleotides 5'-d(CCTA TCGTTATCC) and 5'-d(CCTATCm5GTTATCC).
Polycycl. Aromat. Compds., 17 (1999) 21-32
Nr. 141Jacob, J., Raab, G., Soballa, V.J., Luch, A., Grimmer, G., Greim, H., Doehmer, J., Morrison, H.G., Stegeman, J.J., and Seidel, A.
Species-dependent metabolism of benzo[c]phenanthrene and dibenzo[a,l]pyrene by various CYP450 isoforms.
Polycycl. Aromat. Compds., 16 (1999) 191-203
Species-dependent metabolism of benzo[c]phenanthrene and dibenzo[a,l]pyrene by various CYP450 isoforms.
Polycycl. Aromat. Compds., 16 (1999) 191-203
Nr. 140Baird, W.M., Kaspin, L.C., Kudla, K., Seidel, A., Greim, H., and Luch, A.
Relationship of dibenzo[a,l]pyrene-DNA binding to the induction of p53, p21WAF1 and cell cycle arrest in human cells in culture.
Polycycl. Aromat. Compds., 16 (1999) 119-129
Relationship of dibenzo[a,l]pyrene-DNA binding to the induction of p53, p21WAF1 and cell cycle arrest in human cells in culture.
Polycycl. Aromat. Compds., 16 (1999) 119-129
Nr. 139Luch, A., Coffing, S.L., Seidel, A., Greim, H., Baird, W.M., and Doehmer, J.
DNA modification induced after metabolic activation of the potent carcinogen dibenzo[a,l]pyrene in V79 Chinese hamster cells stably expressing single cytochromes P450.
Polycycl. Aromat. Compds., 16 (1999) 71-78
DNA modification induced after metabolic activation of the potent carcinogen dibenzo[a,l]pyrene in V79 Chinese hamster cells stably expressing single cytochromes P450.
Polycycl. Aromat. Compds., 16 (1999) 71-78
Nr. 138Pradhan, P., Gräslund, A., Seidel, A., and Jernström, B.
Implications of cytosine methylation on (+)-anti-benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide N2-dG adduct formation in 5'-d(CGT), 5'-d(CGA), and 5'-d(CGC) sequence contexts of single- and double-stranded oligonucleotides.
Chem. Res. Toxicol., 12 (1999) 816-821
Implications of cytosine methylation on (+)-anti-benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide N2-dG adduct formation in 5'-d(CGT), 5'-d(CGA), and 5'-d(CGC) sequence contexts of single- and double-stranded oligonucleotides.
Chem. Res. Toxicol., 12 (1999) 816-821
Nr. 137Luch, A., Kishiyama, S., Seidel, A., Doehmer, J., Greim, H., and Baird, W.M.
The K-region trans-8,9-diol does not significantly contribute as an intermediate in the metabolic activation of dibenzo[a,l]pyrene to DNA-binding metabolites by human cytochrome P450 1A1 or 1B1.
Cancer Res., 59 (1999) 4603-4609
The K-region trans-8,9-diol does not significantly contribute as an intermediate in the metabolic activation of dibenzo[a,l]pyrene to DNA-binding metabolites by human cytochrome P450 1A1 or 1B1.
Cancer Res., 59 (1999) 4603-4609
Nr. 136Li, K.-M., George, M., Gross, M.L., Lin, Ch.-H., Small, G.J., Jankowiak, R., Seidel, A., Kroth, H., Eleanor G. Rogan, E.L., and Cavalieri, E.L.
Structure elucidation of the adducts formed by fjord-region dibenzo[a,l]pyrene 11,12-diol 13,14-epoxides with deoxyguanosine.
Chem. Res. Toxicol., 12 (1999) 778-788
Structure elucidation of the adducts formed by fjord-region dibenzo[a,l]pyrene 11,12-diol 13,14-epoxides with deoxyguanosine.
Chem. Res. Toxicol., 12 (1999) 778-788
Nr. 135Li, K.-M., George, M., Gross, M.L., Seidel, A., Luch, A., Rogan, E.G., and Cavalieri, E.L.
Structure elucidation of the adducts formed by fjord-region dibenzo[a,l]pyrene 11,12-diol 13,14-epoxides with deoxyadenosine.
Chem. Res. Toxicol., 12 (1999) 758-767
Structure elucidation of the adducts formed by fjord-region dibenzo[a,l]pyrene 11,12-diol 13,14-epoxides with deoxyadenosine.
Chem. Res. Toxicol., 12 (1999) 758-767
Nr. 134Pal, A., Seidel, A., Xia, H., Hu, X., Oesch, F., and Singh, S.V.
Specificity of murine glutathione S-transferase isozymes in the glutathione conjugation of (-)-anti- and (+)-syn-stereoisomers of benzo[g]chrysene 11,12-dihydrodiol 13,14-epoxide.
Carcinogenesis, 20 (1999) 1997-2001
Specificity of murine glutathione S-transferase isozymes in the glutathione conjugation of (-)-anti- and (+)-syn-stereoisomers of benzo[g]chrysene 11,12-dihydrodiol 13,14-epoxide.
Carcinogenesis, 20 (1999) 1997-2001
Nr. 133Melendez-Colon, V.J., Luch, A., Seidel, A., and Baird, W.M.
Cancer initiation by polycyclic aromatic hydrocarbons results from formation of stable DNA adducts rather than apurinic sites.
Carcinogenesis, 20 (1999) 1885-1891
Cancer initiation by polycyclic aromatic hydrocarbons results from formation of stable DNA adducts rather than apurinic sites.
Carcinogenesis, 20 (1999) 1885-1891
Nr. 132Pradhan, P., Jernström, B., Seidel, A., Nordén, B., and Gräslund, A.
Studies on the adduct heterogeneity of benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide stereo-isomers covalently bound to deoxyribooligonucleotides by induced circular dichroism and light absorption spectroscopy.
Chem. Res. Toxicol., 12 (1999) 403-411
Studies on the adduct heterogeneity of benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide stereo-isomers covalently bound to deoxyribooligonucleotides by induced circular dichroism and light absorption spectroscopy.
Chem. Res. Toxicol., 12 (1999) 403-411
Nr. 131Bluvshtein, E., Glass, G.A., Volohonsky, G., Yaakubowitz, M., Harness, E., Smorodinsky, N., Seidel, A., Frank, H., Steinberg, P., and Stark, A.A.
Inhibition of the hydrolytic and transpeptidase activities of rat kidney g-glutamyl-transpeptidase by specific monoclonal antibodies.
Eur. J. Biochem., 260 (1999) 844-854
Inhibition of the hydrolytic and transpeptidase activities of rat kidney g-glutamyl-transpeptidase by specific monoclonal antibodies.
Eur. J. Biochem., 260 (1999) 844-854
Nr. 130Melendez-Colon, V.J., Luch, A., Seidel, A., and Baird, W.M.
Comparison of cytochrome P450 and peroxidase dependent metabolic activation of the potent carcinogen dibenzo[a,l]pyrene in human cell lines: formation of stable DNA adducts and absence of a detectable increase in apurinic sites.
Cancer Res., 59 (1999) 1412-1416
Comparison of cytochrome P450 and peroxidase dependent metabolic activation of the potent carcinogen dibenzo[a,l]pyrene in human cell lines: formation of stable DNA adducts and absence of a detectable increase in apurinic sites.
Cancer Res., 59 (1999) 1412-1416
Nr. 129Luch, A., Friesel, H., Seidel, A., and Platt, K.L.
Tumor-initiating activity of the (+)-(S,S)- and (-)-(R,R)-enantiomers of trans-11,12-dihydroxy-11,12-dihydrodibenzo[a,l]pyrene in mouse skin.
Cancer Lett., 136 (1999) 119-128
Tumor-initiating activity of the (+)-(S,S)- and (-)-(R,R)-enantiomers of trans-11,12-dihydroxy-11,12-dihydrodibenzo[a,l]pyrene in mouse skin.
Cancer Lett., 136 (1999) 119-128
Nr. 128Luch, A., Schober, W., Soballa, V.J., Raab, G., Greim, H., Jacob, J., Doehmer, J. and Seidel, A.
Metabolic activation of dibenzo[a,l]pyrene by human cytochrome P450 1A1 and P450 1B1 expressed in V79 Chinese hamster cells.
Chem. Res. Toxicol., 12 (1999) 353-364
Metabolic activation of dibenzo[a,l]pyrene by human cytochrome P450 1A1 and P450 1B1 expressed in V79 Chinese hamster cells.
Chem. Res. Toxicol., 12 (1999) 353-364
Nr. 127Erb, C., Seidel, A., Frank, H., Platt, K.L., Oesch, F., and Klein, J.
Formation of N-methylnicotinamide in the brain from a dihydropyridine-type pro-drug: Effect on brain choline.
Biochem. Pharmacol., 57 (1999) 681-684
Formation of N-methylnicotinamide in the brain from a dihydropyridine-type pro-drug: Effect on brain choline.
Biochem. Pharmacol., 57 (1999) 681-684
Nr. 126Luch, A., Kudla, K., Seidel, A., Doehmer, J., Greim, H., and Baird, W.M.
The level of DNA modification by (+)-syn-(11S,12R,13S,14R)- and (-)-anti-(11R,12S,13S,14R)-dihydrodiol epoxides of dibenzo[a,l]pyrene determines the effect on the proteins p53 and p21WAF1 in the human mammary carcinoma cell line MCF-7.
Carcinogenesis, 20 (1999) 859-865
The level of DNA modification by (+)-syn-(11S,12R,13S,14R)- and (-)-anti-(11R,12S,13S,14R)-dihydrodiol epoxides of dibenzo[a,l]pyrene determines the effect on the proteins p53 and p21WAF1 in the human mammary carcinoma cell line MCF-7.
Carcinogenesis, 20 (1999) 859-865
Nr. 125Bock, K.W., Raschko, F.T., Gschaidmeier, H., Seidel, A., Oesch, F., Grove, A.D., Ritter, J.K.
Mono- and diglucuronide formation from benzo[a]pyrene and chrysene diphenols by AHH-1 cell-expressed UDP-glucuronosyltransferase UGT1A7.
Biochem. Pharmacol., 57 (1999) 653-656
Mono- and diglucuronide formation from benzo[a]pyrene and chrysene diphenols by AHH-1 cell-expressed UDP-glucuronosyltransferase UGT1A7.
Biochem. Pharmacol., 57 (1999) 653-656
Nr. 124Doehmer, J., Buters, J.T.M., Luch, A., Soballa, V., Baird, W.M., Morisson, H., Stegeman, J.J., Townsend, A.J., Greenlee, W.F., Glatt, H.R., Seidel, A., Jacob, J., and Greim, H.
Molecular studies on the toxifying effects by genetically engeneered cytochromes P450.
Drug Met. Rev., 31 (1999) 423-435
Molecular studies on the toxifying effects by genetically engeneered cytochromes P450.
Drug Met. Rev., 31 (1999) 423-435
1998
Nr. 123Sundberg, K., Seidel, A., Mannervik, B. and Jernström, B.
Detoxification of carcinogenic fjord-region diol epoxides of polycyclic aromatic hydrocarbons by glutathione transferase P1-1 variants and glutathione.
FEBS Lett, 438 (1998) 206-210
Detoxification of carcinogenic fjord-region diol epoxides of polycyclic aromatic hydrocarbons by glutathione transferase P1-1 variants and glutathione.
FEBS Lett, 438 (1998) 206-210
Nr. 122Seidel, A., Friedberg, T., Löllmann, B., Schwierzok, A., Funk, M., Frank, H., Holler, R., Oesch, F., and Glatt, H.R.
Detoxication of optically active bay- and fjord-region polycyclic aromatic hydrocarbon dihydrodiol epoxides by human glutathione transferase P1-1 expressed in Chinese hamster V79 cells.
Carcinogenesis, 19 (1998) 1975-1981
Detoxication of optically active bay- and fjord-region polycyclic aromatic hydrocarbon dihydrodiol epoxides by human glutathione transferase P1-1 expressed in Chinese hamster V79 cells.
Carcinogenesis, 19 (1998) 1975-1981
Nr. 121Hu, X., Seidel, A., Frank, H., Srivastava, S.K., Xia, H., Pal, A., Zheng, S., Oesch, F., and Singh, S.V.
Differential enantioselectivity of murine glutathione S-transferase isoenzymes in the glutathione conjugation of trans-3,4-dihydroxy-1,2-oxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene stereoisomers.
Ach. Biochem. Biophys., 358 (1998) 40-48
Differential enantioselectivity of murine glutathione S-transferase isoenzymes in the glutathione conjugation of trans-3,4-dihydroxy-1,2-oxy-1,2,3,4-tetrahydrobenzo[c]phenanthrene stereoisomers.
Ach. Biochem. Biophys., 358 (1998) 40-48
Nr. 120Landsiedel, R., Frank, H., Glatt, H.R., and Seidel, A.
Optical resolution of trans-dihydrodiol enantiomers of fjord-region polycyclic aromatic hydrocarbons by HPLC on a chiral cellulose-phase: relationship between elution order and absolute configuration.
J. Chromatogr. A, 822 (1998) 29-35
Optical resolution of trans-dihydrodiol enantiomers of fjord-region polycyclic aromatic hydrocarbons by HPLC on a chiral cellulose-phase: relationship between elution order and absolute configuration.
J. Chromatogr. A, 822 (1998) 29-35
Nr. 119Khan, Q.A., Agarwal, R., Seidel, A., Frank, H., Vousden, K.H., and Dipple, A.
Effects of optical isomers of benzo[g]chrysene anti dihydrodiol epoxide on passage of MCF-7 cells through the cell cycle.
Mol. Carcinog., 23 (1998) 115-120
Effects of optical isomers of benzo[g]chrysene anti dihydrodiol epoxide on passage of MCF-7 cells through the cell cycle.
Mol. Carcinog., 23 (1998) 115-120
Nr. 118Luch, A., Schneider, A., Coffing, S. L., Soballa, V. J., Greim, H., Jefcoate, C.R., Greenlee, W.F., Seidel, A., Baird, W.M., and Doehmer, J.
Stable expression of human cytochrome P450 1B1 in V79 Chinese hamster cells and metabolically catalyzed DNA adduct formation of dibenzo[a,l]pyrene.
Chem. Res. Toxicol., 11 (1998) 686-695
Stable expression of human cytochrome P450 1B1 in V79 Chinese hamster cells and metabolically catalyzed DNA adduct formation of dibenzo[a,l]pyrene.
Chem. Res. Toxicol., 11 (1998) 686-695
Nr. 117Jankowiak, R., Ariese, F., Hewer, A., Luch, A., Zamzow, D., Hughes, N.C., Phillips, D., Seidel, A., Platt, K.L., Oesch, F., and Small, G.J.
Structure, conformations, and repair of DNA adducts from dibenzo[a,l]pyrene: 32P-Postlabeling and fluorescence studies.
Chem. Res. Toxicol., 11 (1998) 674-685
Structure, conformations, and repair of DNA adducts from dibenzo[a,l]pyrene: 32P-Postlabeling and fluorescence studies.
Chem. Res. Toxicol., 11 (1998) 674-685
Nr. 116Landsiedel, R., Pabel, U., Engst, W., Ploschke, J., Seidel, A. and Glatt, H.R.
Chiral inversion of 1-hydroxymethylpyrene enantiomers mediated by enantioselective sulfotransferases.
Biochem. Biophys. Res. Commun., 247 (1998) 181-185
Chiral inversion of 1-hydroxymethylpyrene enantiomers mediated by enantioselective sulfotransferases.
Biochem. Biophys. Res. Commun., 247 (1998) 181-185
Nr. 115Seidel, A., Soballa, V.J., Raab, G., Frank, H., Grimmer, G., Greim, H., Jacob, J., and Doehmer, J.
Regio- and stereoselectivity in the metabolism of benzo[c]phenanthrene mediated by genetically engineered V79 Chinese hamster cells expressing rat and human cytochromes P450.
Environ. Toxicol. Pharmacol., 5 (1998) 179-196
Regio- and stereoselectivity in the metabolism of benzo[c]phenanthrene mediated by genetically engineered V79 Chinese hamster cells expressing rat and human cytochromes P450.
Environ. Toxicol. Pharmacol., 5 (1998) 179-196
Nr. 114Luch, A., Platt, K.L., and Seidel, A.
Synthesis of fjord region tetraols and their use in hepatic biotransformation studies of dihydrodiols of benzo[c]chrysene, benzo[g]chrysene and dibenzo[a,l]pyrene.
Carcinogenesis, 19 (1998) 639-648
Synthesis of fjord region tetraols and their use in hepatic biotransformation studies of dihydrodiols of benzo[c]chrysene, benzo[g]chrysene and dibenzo[a,l]pyrene.
Carcinogenesis, 19 (1998) 639-648
Nr. 113Pradhan, P., Jernström, B., Seidel, A., Nordén, B., and Gräslund, A.
Induced circular dichroism of benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide stereoisomers covalently bound to deoxyribooligonucleotides used to probe equilibrium distribution between groove binding and intercalative adduct conformations.
Biochemistry, 37 (1998) 4664-4673
Induced circular dichroism of benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide stereoisomers covalently bound to deoxyribooligonucleotides used to probe equilibrium distribution between groove binding and intercalative adduct conformations.
Biochemistry, 37 (1998) 4664-4673
Nr. 112Glatt, H.R., Bartsch, I., Christoph, St., Coughtrie, M.W.H., Falany, C.N., Hagen, M., Landsiedel, R., Pabel, U., Phillips, D.H., Seidel, A., Yamazoe, Y.
Sulfotransferase-mediated activation of mutagens, studied using heterologous expression systems.
Chem.-biol. Interact., 109 (1998) 195-219
Sulfotransferase-mediated activation of mutagens, studied using heterologous expression systems.
Chem.-biol. Interact., 109 (1998) 195-219
Nr. 111Sundberg, K., Johansson, A.S., Stenberg, G., Widersten, M., Seidel, A., Mannervik, B. and Jernström, B.
Differences in the catalytic efficiencies of allelic variants of glutathione transferase P1-1 towards carcinogenic diol epoxides of polycyclic aromatic hydrocarbons.
Carcinogenesis, 19 (1998) 433-436
Differences in the catalytic efficiencies of allelic variants of glutathione transferase P1-1 towards carcinogenic diol epoxides of polycyclic aromatic hydrocarbons.
Carcinogenesis, 19 (1998) 433-436
1997
Nr. 110Melendez-Colon, V.J., Smith, C.A., Seidel, A., Luch, A., Platt, K.L., and Baird, W.M.
Formation of stable adducts and absence of depurinating adducts upon reaction of the diol epoxides of the potent carcinogen dibenzo[a,l]pyrene with DNA in solution and in cells.
Proc. Natl. Acad. Sci. U.S.A., 94 (1997) 13542-13547
Formation of stable adducts and absence of depurinating adducts upon reaction of the diol epoxides of the potent carcinogen dibenzo[a,l]pyrene with DNA in solution and in cells.
Proc. Natl. Acad. Sci. U.S.A., 94 (1997) 13542-13547
Nr. 109Giles, A.S., Seidel, A., and Phillips, D.H.
Covalent DNA adducts formed by benzo[c]-chrysene in mouse epidermis and by benzo[c]chrysene fjord-region diol-epoxides reacted with DNA and polynucleotides.
Chem. Res. Toxicol., 10 (1997) 1275-1284
Covalent DNA adducts formed by benzo[c]-chrysene in mouse epidermis and by benzo[c]chrysene fjord-region diol-epoxides reacted with DNA and polynucleotides.
Chem. Res. Toxicol., 10 (1997) 1275-1284
Nr. 108Sundberg, K., Widersten, M., Seidel, A., Mannervik, B., and Jernström, B.
Glutathione conjugation of bay- and fjord-region diol epoxides of polycyclic aromatic hydrocarbons by glutathione transferases M1b-1b and P1-1.
Chem. Res. Toxicol., 10 (1997) 1221-1227
Glutathione conjugation of bay- and fjord-region diol epoxides of polycyclic aromatic hydrocarbons by glutathione transferases M1b-1b and P1-1.
Chem. Res. Toxicol., 10 (1997) 1221-1227
Nr. 107Luch, A., Seidel, A., Glatt, H.R., and Platt, K.L.
Metabolic activation of the (+)-(S,S)- and (-)-(R,R)-enantiomers of trans-11,12-dihydroxy-11,12-dihydrodi-benzo[a,l]pyrene: stereo-selectivity, DNA adduct formation, and mutagenicity in Chinese hamster V79 cells.
Chem. Res. Toxicol., 10 (1997) 1161-1170
Metabolic activation of the (+)-(S,S)- and (-)-(R,R)-enantiomers of trans-11,12-dihydroxy-11,12-dihydrodi-benzo[a,l]pyrene: stereo-selectivity, DNA adduct formation, and mutagenicity in Chinese hamster V79 cells.
Chem. Res. Toxicol., 10 (1997) 1161-1170
Nr. 106Funk, M., Pontén, I., Seidel, A., and Jernström, B.
Critical parameters for adduct formation of the four stereoisomeric benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxides with oligonucleotides.
Bioconjugate Chem., 8 (1997) 310-317
Critical parameters for adduct formation of the four stereoisomeric benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxides with oligonucleotides.
Bioconjugate Chem., 8 (1997) 310-317
Nr. 105Steinberg, P., Heck, R., Frank, H., Odenthal, M., Dienes, H.-P., and Seidel, A.
The role of the Ha-ras gene in the malignant transformation of rat liver oval cells.
Inter. J. Cancer., 71 (1997) 680-685
The role of the Ha-ras gene in the malignant transformation of rat liver oval cells.
Inter. J. Cancer., 71 (1997) 680-685
Nr. 104Ralston, S., Coffing, S., Seidel, A., Luch, A., Platt, K.L., and Baird, W.M.
Stereoselective activation of dibenzo[a,l]pyrene and its trans-11,12-dihydrodiol to fjord region 11,12-diol 13,14-epoxides in a human mammary carcinoma MCF-7 cell-mediated V79 cell mutation assay.
Chem. Res. Toxicol., 10 (1997) 687-693
Stereoselective activation of dibenzo[a,l]pyrene and its trans-11,12-dihydrodiol to fjord region 11,12-diol 13,14-epoxides in a human mammary carcinoma MCF-7 cell-mediated V79 cell mutation assay.
Chem. Res. Toxicol., 10 (1997) 687-693
Nr. 103Jankowiak, R., Ariese, F., Zamzow, D., Luch, A., Kroth, H., Seidel, A., and Small, G.J.
Conformational studies of stereoisomeric tetraols derived from syn- and anti-dibenzo[a,l]pyrene diolepoxides.
Chem. Res. Toxicol., 10 (1997) 677-686
Conformational studies of stereoisomeric tetraols derived from syn- and anti-dibenzo[a,l]pyrene diolepoxides.
Chem. Res. Toxicol., 10 (1997) 677-686
Nr. 102Hanelt, S., Helbig, R., Hartmann, A., Lang, M., Seidel, A., and Speit, G.
A comparative investigation of DNA adducts, DNA strand breaks and gene mutations induced by benzo[a]pyrene and (±)-benzo[a]pyrene-7,8-diol-9,10-epoxide in cultured human cells.
Mutagenesis, 390 (1997) 179-188
A comparative investigation of DNA adducts, DNA strand breaks and gene mutations induced by benzo[a]pyrene and (±)-benzo[a]pyrene-7,8-diol-9,10-epoxide in cultured human cells.
Mutagenesis, 390 (1997) 179-188
Nr. 101Müller, F., Arand, A., Frank, H., Seidel, A., Hinz, W., Winkler, L., Hänel, K., Blée, E., Beetham, J.K., Hammock, B.D., and Oesch, F.
Visualization of the covalent intermediate formed between microsomal epoxide hydrolase and 9,10-epoxystearic acid during enzymatic epoxide hydrolysis.
Eur. J. Biochem., 245 (1997) 490-496
Visualization of the covalent intermediate formed between microsomal epoxide hydrolase and 9,10-epoxystearic acid during enzymatic epoxide hydrolysis.
Eur. J. Biochem., 245 (1997) 490-496
Nr. 100Turchi, G., Glatt, H.R., Seidel, A., Puliti, A., and Sbrana, I.
Structure-activity relationship in the induction of chromosomal aberrations and spindle disturbances in Chinese hamster epithelial liver cells by regioisomeric phenanthrene quinones.
Cell Biol. Toxicol., 13 (1997) 155-165
Structure-activity relationship in the induction of chromosomal aberrations and spindle disturbances in Chinese hamster epithelial liver cells by regioisomeric phenanthrene quinones.
Cell Biol. Toxicol., 13 (1997) 155-165
1996
Nr. 99Kroth, H., Oesch, F., and Seidel, A.
Synthesis of stereoisomeric N6-deoxy-adenosine adducts of syn- and anti-dihydrodiol epoxides of benzo[a]pyrene and their incorporation into 18-mer DNA sequences from human Ha-ras protooncogene.
Polycycl. Arom. Compds., 11 (1996) 349-356
Synthesis of stereoisomeric N6-deoxy-adenosine adducts of syn- and anti-dihydrodiol epoxides of benzo[a]pyrene and their incorporation into 18-mer DNA sequences from human Ha-ras protooncogene.
Polycycl. Arom. Compds., 11 (1996) 349-356
Nr. 98Landsiedel, R., Engst, W., Scholtyssek, M., Seidel, A., Glatt, H.R.
Nucleophilic displacement reactions at the benzylic position of the sulfuric acid ester 1-sulfooxymethylpyrene: Potential influence on in vivo reactivity.
Polycycl. Arom. Compds., 11 (1996) 341-348
Nucleophilic displacement reactions at the benzylic position of the sulfuric acid ester 1-sulfooxymethylpyrene: Potential influence on in vivo reactivity.
Polycycl. Arom. Compds., 11 (1996) 341-348
Nr. 97Buchwald-Goebel, S., Oesch, F., and Seidel, A.
A tandem photochemical approach for the synthesis of biologically important metabolites of benzo[b]fluoranthene.
Polycycl. Arom. Compds., 11 (1996) 325-332
A tandem photochemical approach for the synthesis of biologically important metabolites of benzo[b]fluoranthene.
Polycycl. Arom. Compds., 11 (1996) 325-332
Nr. 96Steinberg, P., Oesch, F., and Seidel, A.
The stereoisomeric fjord-region benzo[c]-phenanthrene-3,4-dihydrodiol 1,2-oxides malignantly transform rat liver epithelial cells.
Polycycl. Arom. Compds., 10 (1996) 275-282
The stereoisomeric fjord-region benzo[c]-phenanthrene-3,4-dihydrodiol 1,2-oxides malignantly transform rat liver epithelial cells.
Polycycl. Arom. Compds., 10 (1996) 275-282
Nr. 95Baird, W.M., Ralston, S., Luch, A., Platt, K.L., and Seidel, A.
Stereoselective metabolic activation of dibenzo[a,l]pyrene in the human mammary carcinoma cell line MCF-7 results in formation of (-)-anti and (+)-syn-11,12-diol-13,14-epoxide-deoxyadenosine adducts in DNA.
Polycycl. Arom. Compds., 10 (1996) 235-242
Stereoselective metabolic activation of dibenzo[a,l]pyrene in the human mammary carcinoma cell line MCF-7 results in formation of (-)-anti and (+)-syn-11,12-diol-13,14-epoxide-deoxyadenosine adducts in DNA.
Polycycl. Arom. Compds., 10 (1996) 235-242
Nr. 94Pfau, W., Seidel, A., Phillips, D.H., Oesch, F., and Grover, P.L.
32P-postlabelling/ HPLC analysis of DNA adducts formed from chrysene and its metabolites.
Polycycl. Arom. Compds., 10 (1996) 219-226
32P-postlabelling/ HPLC analysis of DNA adducts formed from chrysene and its metabolites.
Polycycl. Arom. Compds., 10 (1996) 219-226
Nr. 93Seidel, A., Sun, Z., Kroth, H., Steinbrecher, T., Oesch, F., and Friedberg, T.
DNA-polymerase action on oligonucleotide templates from human Ha-ras proto-oncogenes containing N6-deoxyadenosine adducts derived from trans addition of (+)- and (-)-anti-benzo[c]phenanthrene-3,4-dihydrodiol 1,2-oxide at Codon 61.
Polycycl. Arom. Compds., 10 (1996) 161-170
DNA-polymerase action on oligonucleotide templates from human Ha-ras proto-oncogenes containing N6-deoxyadenosine adducts derived from trans addition of (+)- and (-)-anti-benzo[c]phenanthrene-3,4-dihydrodiol 1,2-oxide at Codon 61.
Polycycl. Arom. Compds., 10 (1996) 161-170
Nr. 92Frank, H., Luch, A., Oesch, F., and Seidel, A.
4-[4(Dimethylamino)phenylazo]-benzoate, a new red-shifted chromophore for use in the exciton chirality method: Assignment of absolute configuration to fjord-region metabolites of dibenzo[a,l]pyrene.
Polycycl. Arom. Compds., 10 (1996) 109-116
4-[4(Dimethylamino)phenylazo]-benzoate, a new red-shifted chromophore for use in the exciton chirality method: Assignment of absolute configuration to fjord-region metabolites of dibenzo[a,l]pyrene.
Polycycl. Arom. Compds., 10 (1996) 109-116
Nr. 91Luch, A., Seidel, A., Glatt, H.R., Oesch, F., and Platt, K.L.
Correlation of the extent of fjord-region oxidation with DNA binding and mutagenicity of the enantiomeric 11,12-dihydrodiols of dibenzo[a,l]pyrene in vitro.
Polycycl. Arom. Compds., 10 (1996) 101-108
Correlation of the extent of fjord-region oxidation with DNA binding and mutagenicity of the enantiomeric 11,12-dihydrodiols of dibenzo[a,l]pyrene in vitro.
Polycycl. Arom. Compds., 10 (1996) 101-108
Nr. 90Ponten, I., Seidel, A., Gräslund, A., and Jernström, B.
Studies on oligonucleotides modified with the enantiomers of the anti- and syn-diastereomers of benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide.
Polycycl. Arom. Compds., 10 (1996) 93-100
Studies on oligonucleotides modified with the enantiomers of the anti- and syn-diastereomers of benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide.
Polycycl. Arom. Compds., 10 (1996) 93-100
Nr. 89Degenhardt, C., Bors, W., Seidel, A., Frank, H., and Platt, K.L.
Metabolic activation of anthanthrene: Significance of stable radicals derived from its key metabolite 3-hydroxy-anthanthrene.
Polycycl. Arom. Compds., 10 (1996) 85-92
Metabolic activation of anthanthrene: Significance of stable radicals derived from its key metabolite 3-hydroxy-anthanthrene.
Polycycl. Arom. Compds., 10 (1996) 85-92
Nr. 88Reindl, M., Seidel, A., Frank, H. and Platt, K.L.
Detection of reactive quinones in the metabolism of polycyclic aromatic hydrocarbons by the formation of their glutathione conjugates.
Polycycl. Arom. Compds., 10 (1996) 77-84
Detection of reactive quinones in the metabolism of polycyclic aromatic hydrocarbons by the formation of their glutathione conjugates.
Polycycl. Arom. Compds., 10 (1996) 77-84
Nr. 87Jernström, B., Mannervik, B., Funk, M., and Seidel, A.
Glutathione conjugation of diol epoxides of polycyclic aromatic hydrocarbons catalyzed by human glutathione transferase A1-1.
Polycycl. Arom. Compds., 10 (1996) 51-57
Glutathione conjugation of diol epoxides of polycyclic aromatic hydrocarbons catalyzed by human glutathione transferase A1-1.
Polycycl. Arom. Compds., 10 (1996) 51-57
Nr. 86Jacob, J., Doehmer, J., Grimmer, G., Soballa, V., Raab, G., Seidel, A., and Greim, H.
Metabolism of phenanthrene, benz[a]anthracene, benzo[a]pyrene and benzo[c]phenanthrene by eight cDNA-expressed human and rat cytochromes.
Polycycl. Arom. Compds., 10 (1996) 1-9
Metabolism of phenanthrene, benz[a]anthracene, benzo[a]pyrene and benzo[c]phenanthrene by eight cDNA-expressed human and rat cytochromes.
Polycycl. Arom. Compds., 10 (1996) 1-9
Nr. 85Speit, G., Hanelt, S., Helbig, R., Seidel, A. and Hartmann, A.
Detection of DNA effects in human cells with the comet assay and their relevance for mutagenesis.
Toxicol. Lett., 88 (1996) 91-98
Detection of DNA effects in human cells with the comet assay and their relevance for mutagenesis.
Toxicol. Lett., 88 (1996) 91-98
Nr. 84Glatt, H.R., Christoph, S., Czich, A., Pauly, K., Schwierzok, A., Seidel, A., Coughtrie, M.W.H., Doehmer, J., Falany, C.N., Phillips, D.H., Yamazoe, Y., and Bartsch, I.
Rat and human sulfotransferases expressed in Ames's Salmonella typhimurium strains and Chinese hamster V79 cells for the activation of mutagens.
Control Mechanisms of Carcinogenesis (ed's J.G. Hengstler and F. Oesch), Publishing House of the Editors: J.G. Hengstler & F. Oesch (1996) p. 98-115
Rat and human sulfotransferases expressed in Ames's Salmonella typhimurium strains and Chinese hamster V79 cells for the activation of mutagens.
Control Mechanisms of Carcinogenesis (ed's J.G. Hengstler and F. Oesch), Publishing House of the Editors: J.G. Hengstler & F. Oesch (1996) p. 98-115
Nr. 83Jernström, B., Funk, M., Frank, H., Mannervik, B., and Seidel, A.
Glutathione tranferase A1-1 catalyzed conjugation of bay- and fjord-region diol epoxides of polycyclic aromatic hydrocarbons with glutathione.
Carcinogenesis, 17 (1996) 1491-1498
Glutathione tranferase A1-1 catalyzed conjugation of bay- and fjord-region diol epoxides of polycyclic aromatic hydrocarbons with glutathione.
Carcinogenesis, 17 (1996) 1491-1498
Nr. 82Giles, A.S., Seidel, A., and Phillips, D.H.
Covalent DNA adducts formed in mouse epidermis by benzo[g]chrysene.
Carcinogenesis, 17 (1996) 1331-1336
Covalent DNA adducts formed in mouse epidermis by benzo[g]chrysene.
Carcinogenesis, 17 (1996) 1331-1336
Nr. 81Windsor, S.A., Tinker, M.H., Osborne, M.R. and Seidel, A.
Studies of the binding of diol-epoxide metabolites of polycyclic aromatic hydrocarbons to DNA using electro-fluorescence polarization spectroscopy.
Carcinogenesis, 17 (1996) 605-608
Studies of the binding of diol-epoxide metabolites of polycyclic aromatic hydrocarbons to DNA using electro-fluorescence polarization spectroscopy.
Carcinogenesis, 17 (1996) 605-608
Nr. 80Jacob, J., Raab, G., Soballa, V., Holtkamp, D., Schmalix, W., Grimmer, G., Greim, H. Doehmer, J., and Seidel, A.
Cytochrome P450-mediated activation of phenanthrene in genetically engineered V79 Chinese hamster cells.
Environ. Toxicol. Pharmacol., 1 (1996) 1-11
Cytochrome P450-mediated activation of phenanthrene in genetically engineered V79 Chinese hamster cells.
Environ. Toxicol. Pharmacol., 1 (1996) 1-11
Nr. 79Pontén, I., Seidel, A., Gräslund, A., and Jernström, B.
Characterization of adducts derived from the syn-diastereomer of benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide and the oligonucleotide 5'-d(CCTATAGATATCC).
Chem. Res. Toxicol., 9 (1996) 188-196
Characterization of adducts derived from the syn-diastereomer of benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide and the oligonucleotide 5'-d(CCTATAGATATCC).
Chem. Res. Toxicol., 9 (1996) 188-196
1995
Nr. 78Glatt, H., Bartsch I., Czich A., Seidel A. and Falany C.N.
Salmonella strains and mammalian cells genetically engineered for expression of sulfotransferases.
Toxicol. Lett., 82-3 (1995) 829-834
Salmonella strains and mammalian cells genetically engineered for expression of sulfotransferases.
Toxicol. Lett., 82-3 (1995) 829-834
Nr. 77Ralston, S., Seidel, A., Platt, K.L., Luch, A., and Baird, W.M.
Stereochemical selectivity of activation of dibenzo[a,l]pyrene to (-)-anti- and (+)-syn-DB[a,l]P-11,12-diol-13,14-epoxide which bind extensively to deoxyadenosine residues of DNA in the human mammary carcinoma cell line MCF-7.
Carcinogenesis, 16 (1995) 2899-2907
Stereochemical selectivity of activation of dibenzo[a,l]pyrene to (-)-anti- and (+)-syn-DB[a,l]P-11,12-diol-13,14-epoxide which bind extensively to deoxyadenosine residues of DNA in the human mammary carcinoma cell line MCF-7.
Carcinogenesis, 16 (1995) 2899-2907
Nr. 76Sbrana, I., Puliti, A., Seidel, A., Glatt, H.R., and Turchi, G.
Induction of chromosomal aberrations and spindle disturbances in Chinese hamster epithelial liver cells in culture by pyrene and benzo[a]pyrene quinones.
Mutagenesis, 10 (1995) 505-512
Induction of chromosomal aberrations and spindle disturbances in Chinese hamster epithelial liver cells in culture by pyrene and benzo[a]pyrene quinones.
Mutagenesis, 10 (1995) 505-512
Nr. 75Du, M.Q., Seidel, A., and Phillips, D.H.
Activating mutations in human c-Ha-ras-1 protooncogene induced by the stereoisomeric fjord-region benzo[c]chrysene-9,10-diol 13,14-epoxides.
Mol. Carcinogen., 14 (1995) 160-169
Activating mutations in human c-Ha-ras-1 protooncogene induced by the stereoisomeric fjord-region benzo[c]chrysene-9,10-diol 13,14-epoxides.
Mol. Carcinogen., 14 (1995) 160-169
Nr. 74Seidel, A., Oesch, F., and Steinberg, P.
Malignant transformation of the liver tumor precursor cell line OC/CDE 22 by the four stereoisomeric fjord-region 3,4-dihydrodiol 1,2-epoxides of benzo[c]phenanthrene.
Carcinogenesis, 16 (1995) 2111-2115
Malignant transformation of the liver tumor precursor cell line OC/CDE 22 by the four stereoisomeric fjord-region 3,4-dihydrodiol 1,2-epoxides of benzo[c]phenanthrene.
Carcinogenesis, 16 (1995) 2111-2115
Nr. 73Goeptar, A.R., te Koppele, J.M., Glatt, H.R., Groot, E.J., Seidel, A., Barrenscheen, M., Wölfel, C., Doehmer, J., Vermeulen, N.P.E.
The cytotoxicity of mitomycin C and adriamycin in genetically engeneered V79 cell lines and freshly isolated hepatocytes.
Chem.-Biol. Interact., 97 (1995) 149-168
The cytotoxicity of mitomycin C and adriamycin in genetically engeneered V79 cell lines and freshly isolated hepatocytes.
Chem.-Biol. Interact., 97 (1995) 149-168
Nr. 72Gschaidmaier, H., Seidel, A., Burchell, B. and Bock, K.W.
Formation of mono- and diglucuronides and of other glycosides of benzo[a]pyrene-3,6-quinol by V79 cell-expressed human phenol UDP-glucuronsyltransferase of the UGT1 complex (UGT1.6 and UGT1.07).
Biochem. Pharmacol., 49 (1995) 1601-1606
Formation of mono- and diglucuronides and of other glycosides of benzo[a]pyrene-3,6-quinol by V79 cell-expressed human phenol UDP-glucuronsyltransferase of the UGT1 complex (UGT1.6 and UGT1.07).
Biochem. Pharmacol., 49 (1995) 1601-1606
Nr. 71Funk, M., Gath, I., Seidel, A., Oesch, F., and Platt, K.L.
Conjugation of anti-dihydrodiol epoxides of benzo[a]pyrene, chrysene, benzo[c]phenanthrene and dibenz[a,h]anthracene with glutathione catalysed by cytosol and by the mu-class glutathione transferase HTP II from rat liver.
Chem. Biol. Interact., 95 (1995) 189-201
Conjugation of anti-dihydrodiol epoxides of benzo[a]pyrene, chrysene, benzo[c]phenanthrene and dibenz[a,h]anthracene with glutathione catalysed by cytosol and by the mu-class glutathione transferase HTP II from rat liver.
Chem. Biol. Interact., 95 (1995) 189-201
Nr. 70Giles, A., Seidel, A., and Phillips, D.H.
Reactivities towards DNA of the fjord-region diol-epoxides of benzo[g]chrysene and benzo[c]phenanthrene as revealed by 32P-postlabeling.
Chem. Res. Toxicol., 8 (1995) 591 - 599
Reactivities towards DNA of the fjord-region diol-epoxides of benzo[g]chrysene and benzo[c]phenanthrene as revealed by 32P-postlabeling.
Chem. Res. Toxicol., 8 (1995) 591 - 599
Nr. 69Doehmer, J, Holtkamp, D, Soballa, V., Raab, G., Schmalix, W., Seidel, A., Greim, H. and Jacob, J.
Cytochrome P450 mediated reactions studied in genetically engineered V79 Chinese hamster cells.
Pharmacogenetics, 5 (1995) S91 - S96
Cytochrome P450 mediated reactions studied in genetically engineered V79 Chinese hamster cells.
Pharmacogenetics, 5 (1995) S91 - S96
1994
Nr. 68Glatt, H.R., Pauly, K., Frank, H., Seidel, A., Oesch, F., Harvey, R.G., and Werle-Scheider, G.
Substance-dependent sex differences in the activation of benzylic alcohols to mutagens by hepatic sulfotransferases of the rat.
Carcinogenesis, 15 (1994) 2605-2611
Substance-dependent sex differences in the activation of benzylic alcohols to mutagens by hepatic sulfotransferases of the rat.
Carcinogenesis, 15 (1994) 2605-2611
Nr. 67Luch, A., Glatt, H.R., Platt, K.L., Oesch, F., and Seidel, A.
Synthesis and mutagenicity of the diastereomeric fjord-region 11,12-dihydrodiol 13,14-epoxides of dibenzo[a,l]pyrene.
Carcinogenesis, 15 (1994) 2507-2516
Synthesis and mutagenicity of the diastereomeric fjord-region 11,12-dihydrodiol 13,14-epoxides of dibenzo[a,l]pyrene.
Carcinogenesis, 15 (1994) 2507-2516
Nr. 66Glatt, H.R., Pauly, K., Piée-Staffa, Seidel, A., Hornhardt, S., and Czich, A.
Activation of promutagens by endogenous and heterologous sulfotransferases expressed in continous cell cultures.
Toxicology Lett., 72 (1994) 13-21
Activation of promutagens by endogenous and heterologous sulfotransferases expressed in continous cell cultures.
Toxicology Lett., 72 (1994) 13-21
Nr. 65Glatt, H.R., Werle-Schneider, G., Enders, N., Monnerjahn, S., Pudil, J., Czich, A., Seidel, A., and Schwarz, M.
1-Hydroxymethylpyrene and its sulfuric acid ester: toxicological effects in vitro and in vivo, and metabolic aspects.
Chem.-Biol. Interact., 92 (1994) 305-319
1-Hydroxymethylpyrene and its sulfuric acid ester: toxicological effects in vitro and in vivo, and metabolic aspects.
Chem.-Biol. Interact., 92 (1994) 305-319
Nr. 64Glatt, H.R., Werle-Schneider, G., Seidel, A., and Schwarz, M.
Initiation and promotion of enzyme-altered foci in rat liver by 1-hydroxymethylpyrene.
Polycycl. Arom. Compds., 7 (1994) 153-160
Initiation and promotion of enzyme-altered foci in rat liver by 1-hydroxymethylpyrene.
Polycycl. Arom. Compds., 7 (1994) 153-160
Nr. 63Glatt, H.R., Pudil, J., Seidel, A., and Czich, A.
Stable expression of heterologous sulfo-transferase in V79 cells: activation of primary and secondary benzylic alcohols.
Polycycl. Arom. Compds., 7 (1994) 67-74
Stable expression of heterologous sulfo-transferase in V79 cells: activation of primary and secondary benzylic alcohols.
Polycycl. Arom. Compds., 7 (1994) 67-74
Nr. 62Ralston, S.L., Lau, H.H.S., Seidel, A., Luch, A., Platt, K.L., and Baird, W.M.
Identification of dibenzo[a,l]pyrene-DNA adducts formed in cells in culture and in mouse skin.
Polycycl. Arom. Compds., 6 (1994) 199-206
Identification of dibenzo[a,l]pyrene-DNA adducts formed in cells in culture and in mouse skin.
Polycycl. Arom. Compds., 6 (1994) 199-206
Nr. 61Seidel, A., Luch, A., Platt, K.L., Oesch, F., and Glatt, H.R.
Activated fjord-region metabolites of dibenzo[a,l]pyrene: Synthesis and mutagenic activities of the diastereomeric syn- and anti-11,12-dihydrodiol 13,14-epoxides.
Polycycl. Arom. Compds., 6 (1994) 191-198
Activated fjord-region metabolites of dibenzo[a,l]pyrene: Synthesis and mutagenic activities of the diastereomeric syn- and anti-11,12-dihydrodiol 13,14-epoxides.
Polycycl. Arom. Compds., 6 (1994) 191-198
Nr. 60Glatt, H.R., Seidel, A., Oesch, F., and Gumbsch, A.
Fjord-region diol-epoxides of benzo[c]chrysene are potent inducers of micronuclei in murine bone marrow.
Mutat. Res., 309 (1994) 37-43
Fjord-region diol-epoxides of benzo[c]chrysene are potent inducers of micronuclei in murine bone marrow.
Mutat. Res., 309 (1994) 37-43
Nr. 59Post, K., Seidel, A., Platt, K. L., Oesch, F., and Klein, J.
Regiospecific oxidation of dihydrodiols and reduction of quinones by rabbit liver dihydrodiol dehydrogenase.
Chem.-Biol. Interact., 90 (1994) 157-168
Regiospecific oxidation of dihydrodiols and reduction of quinones by rabbit liver dihydrodiol dehydrogenase.
Chem.-Biol. Interact., 90 (1994) 157-168
Nr. 58Funk, M., Gath, I., Seidel, A., Platt, K. L., Oesch, F. and Zeller, H.D.
Different enzyme kinetics during the glutathione conjugation of the four stereoisomeric forms of the fjord-region diolepoxide of benzo[c]phenanthrene by the acidic rat liver glutathione S-transferase HTP II.
Biochem. Pharmacol., 47 (1994) 505-514
Different enzyme kinetics during the glutathione conjugation of the four stereoisomeric forms of the fjord-region diolepoxide of benzo[c]phenanthrene by the acidic rat liver glutathione S-transferase HTP II.
Biochem. Pharmacol., 47 (1994) 505-514
Nr. 57Ralston, S.L., Lau, H.H.S., Seidel, A., Luch, A., Platt, K.L., and Baird, W.M.
The potent carcinogen dibenzo[a,l]pyrene is metabolically activated to fjord-region 11,12-diol 13,14-epoxides in human mammary carcinoma MCF-7 cell cultures.
Cancer Res., 54 (1994) 887 - 890
The potent carcinogen dibenzo[a,l]pyrene is metabolically activated to fjord-region 11,12-diol 13,14-epoxides in human mammary carcinoma MCF-7 cell cultures.
Cancer Res., 54 (1994) 887 - 890
1993
Nr. 56Schmalix, W.A., Mäser, H., Kiefer, F., Reen, R., Wiebel, F.J., Gonzalez, F., Seidel, A., Glatt, H.R., Greim, H., and Doehmer, J.
Stable expression of human cytochrome P450 1A1 cDNA in V79 Chinese hamster cells and metabolic activation of benzo[a]pyrene.
Eur. J. Pharmacol. - Environ. Toxicol. Pharmacol. Sec., 248 (1993) 251 - 261
Stable expression of human cytochrome P450 1A1 cDNA in V79 Chinese hamster cells and metabolic activation of benzo[a]pyrene.
Eur. J. Pharmacol. - Environ. Toxicol. Pharmacol. Sec., 248 (1993) 251 - 261
Nr. 55Glatt, H. R., Henschler, R., Frank, H., Seidel, A., Oesch, F., Yang, C. X., Abu-Shqara, E., and Harvey, R. G.
Sulfotransferase-mediated mutagenicity of 1-hydroxymethyl-pyrene and 4H-cyclopenta[def]chrysen-4-ol and its enhancement by chloride anions.
Carcinogenesis, 14 (1993) 599-602
Sulfotransferase-mediated mutagenicity of 1-hydroxymethyl-pyrene and 4H-cyclopenta[def]chrysen-4-ol and its enhancement by chloride anions.
Carcinogenesis, 14 (1993) 599-602
Nr. 54Steinbrecher, T., Becker, A, Stezowski, J.J., Oesch, F., and Seidel, A.
Synthesis of oligodeoxynucleotides containing diastereomeric diol epoxide-N6-deoxy-adenosine adducts of polycyclic aromatic hydrocarbons.
Tetrahedron Lett., 34 (1993) 1773-1774
Synthesis of oligodeoxynucleotides containing diastereomeric diol epoxide-N6-deoxy-adenosine adducts of polycyclic aromatic hydrocarbons.
Tetrahedron Lett., 34 (1993) 1773-1774
Nr. 53Jernström, B., Funk, M., Steinbrecher, T., and Seidel, A.
Glutathione transferase catalyzed conjugation of diol epoxides derived from polycyclic aromatic hydrocarbons with glutathione.
Polycycl. Arom. Compds., 3 (1993) 213 - 219
Glutathione transferase catalyzed conjugation of diol epoxides derived from polycyclic aromatic hydrocarbons with glutathione.
Polycycl. Arom. Compds., 3 (1993) 213 - 219
Nr. 52Pfau, W., Lecoq, S., Hughes, N.C., Seidel, A., Platt, K.L., Grover, P.L., and Phillips, D.H.
Formation of DNA adducts by 1-hydroxy-methylpyrene in liver cells in vivo and in vitro.
Postlabelling Methods for Detection of DNA Adducts, IARC Scientific Publication No. 124, IARC, Lyon (France) (1993) pp 233 - 242
Formation of DNA adducts by 1-hydroxy-methylpyrene in liver cells in vivo and in vitro.
Postlabelling Methods for Detection of DNA Adducts, IARC Scientific Publication No. 124, IARC, Lyon (France) (1993) pp 233 - 242
Nr. 51Monnerjahn, S., Seidel, A., Steinberg, P., Oesch, F., Hinz, M., Stezowski, J.J., Hewer, A., Phillips, D.H., and Glatt, H.R.
Formation of DNA adducts by 1-hydroxymethylpyrene in liver cells in vivo and in vitro.
Postlabelling Methods for Detection of DNA Adducts, IARC Scientific Publication No. 124, IARC, Lyon (France) (1993) pp 189 - 193
Formation of DNA adducts by 1-hydroxymethylpyrene in liver cells in vivo and in vitro.
Postlabelling Methods for Detection of DNA Adducts, IARC Scientific Publication No. 124, IARC, Lyon (France) (1993) pp 189 - 193
Nr. 50Glatt, H. R., Pauly, K., Wölfel, C., Dogra, S., Seidel, A., Lee, H., Harvey, R.G., Oesch, F., and Doehmer, J.
Stable expression of heterologous cytochromes P450 in V79 cells: mutagenicity studies with polycyclic aromatic hydrocarbons.
Polycyclic Aromatic Compounds: Synthesis, Properties, Analytical Measurements, Occurrence and Biological Effects (P. Garrigues and M. Lamotte, eds.) Gordon and Breach Science Publishers, Yverdon (Switzerland) (1993) pp 1167 - 1174
Stable expression of heterologous cytochromes P450 in V79 cells: mutagenicity studies with polycyclic aromatic hydrocarbons.
Polycyclic Aromatic Compounds: Synthesis, Properties, Analytical Measurements, Occurrence and Biological Effects (P. Garrigues and M. Lamotte, eds.) Gordon and Breach Science Publishers, Yverdon (Switzerland) (1993) pp 1167 - 1174
Nr. 49Lecoq, S., Platt, K.L., Seidel, A., Oesch, F., Phillips, D.H., and Grover, P.L.
Comparisons of the metabolic activation of dibenz[a,h]anthracene and picene using 32P-postlabelling.
Polycyclic Aromatic Compounds: Synthesis, Properties, Analytical Measurements, Occurrence and Biological Effects (P. Garrigues and M. Lamotte, eds.) Gordon and Breach Science Publishers, Yverdon (Switzerland) (1993) pp 921 - 928
Comparisons of the metabolic activation of dibenz[a,h]anthracene and picene using 32P-postlabelling.
Polycyclic Aromatic Compounds: Synthesis, Properties, Analytical Measurements, Occurrence and Biological Effects (P. Garrigues and M. Lamotte, eds.) Gordon and Breach Science Publishers, Yverdon (Switzerland) (1993) pp 921 - 928
Nr. 48Enders, N., Seidel, A., Monnerjahn, S. and Glatt, H.R.
Synthesis of 11 benzylic sulfate esters and their bacterial mutagenicity in dependence of the presence of chloride, bromide and acetate anions.
Polycyclic Aromatic Compounds: Synthesis, Properties, Analytical Measurements, Occurrence and Biological Effects (P. Garrigues and M. Lamotte, eds.) (Supplement to Polycyclic Aromatic Compounds, Vol. 3), Gordon and Breach Science Publishers, Yverdon (Swit (1993) pp 887 - 894
Synthesis of 11 benzylic sulfate esters and their bacterial mutagenicity in dependence of the presence of chloride, bromide and acetate anions.
Polycyclic Aromatic Compounds: Synthesis, Properties, Analytical Measurements, Occurrence and Biological Effects (P. Garrigues and M. Lamotte, eds.) (Supplement to Polycyclic Aromatic Compounds, Vol. 3), Gordon and Breach Science Publishers, Yverdon (Swit (1993) pp 887 - 894
Nr. 47Glatt, H.R., Wameling, C., Elsberg, S., Thomas, H., Marquardt, H., Hewer, A., Phillips, D.H., Oesch, F., and Seidel, A.
"Reverse" diol-epoxides of chrysene: genotoxicity characteristics.
Polycyclic Aromatic Compounds: Synthesis, Properties, Analytical Measurements, Occurrence and Biological Effects (P. Garrigues and M. Lamotte, eds.) Gordon and Breach Science Publishers, Yverdon (Switzerland) (1993) pp 879 - 886
"Reverse" diol-epoxides of chrysene: genotoxicity characteristics.
Polycyclic Aromatic Compounds: Synthesis, Properties, Analytical Measurements, Occurrence and Biological Effects (P. Garrigues and M. Lamotte, eds.) Gordon and Breach Science Publishers, Yverdon (Switzerland) (1993) pp 879 - 886
Nr. 46Johannes, A., Schmoldt, A., Seidel, A., and Glatt, H.R.
Sulfate conjugation of various hydroxy-PAH by rat liver sulfotransferases.
Polycyclic Aromatic Compounds: Synthesis, Properties, Analytical Measurements, Occurrence and Biological Effects (P. Garrigues and M. Lamotte, eds.) Gordon and Breach Science Publishers, Yverdon (Switzerland) (1993) pp 703 - 710
Sulfate conjugation of various hydroxy-PAH by rat liver sulfotransferases.
Polycyclic Aromatic Compounds: Synthesis, Properties, Analytical Measurements, Occurrence and Biological Effects (P. Garrigues and M. Lamotte, eds.) Gordon and Breach Science Publishers, Yverdon (Switzerland) (1993) pp 703 - 710
Nr. 45Augustin, C., Schmoldt, A., Glatt, H.R., and Seidel, A.
Various UDP-glucuronosyl-transferases involved in regiospecific conjugations of hydroxy-PAH.
Polycyclic Aromatic Compounds: Synthesis, Properties, Analytical Measurements, Occurrence and Biological Effects (P. Garrigues and M. Lamotte, eds.) Gordon and Breach Science Publishers, Yverdon (Switzerland) (1993) pp 687 - 694
Various UDP-glucuronosyl-transferases involved in regiospecific conjugations of hydroxy-PAH.
Polycyclic Aromatic Compounds: Synthesis, Properties, Analytical Measurements, Occurrence and Biological Effects (P. Garrigues and M. Lamotte, eds.) Gordon and Breach Science Publishers, Yverdon (Switzerland) (1993) pp 687 - 694
Nr. 44Steinbrecher, T., Wameling, C., Oesch, F., and Seidel, A.
Synthesis of polycyclic aromatic hydrocarbon adducts attached to the exocyclic amino group of 2'-deoxyguanosine via nucleophilic substitution.
Polycyclic Aromatic Compounds: Synthesis, Properties, Analytical Measurements, Occurrence and Biological Effects (P. Garrigues and M. Lamotte, eds.) Gordon and Breach Science Publishers, Yverdon (Switzerland) (1993) pp 223 - 230
Synthesis of polycyclic aromatic hydrocarbon adducts attached to the exocyclic amino group of 2'-deoxyguanosine via nucleophilic substitution.
Polycyclic Aromatic Compounds: Synthesis, Properties, Analytical Measurements, Occurrence and Biological Effects (P. Garrigues and M. Lamotte, eds.) Gordon and Breach Science Publishers, Yverdon (Switzerland) (1993) pp 223 - 230
Nr. 43Funk, M., Frank, H., Platt, K. L., Oesch, F., and Seidel, A.
Synthesis and characterization of glutathione conjugates of diastereomeric bay- and fjord-region dihydrodiol epoxides.
Polycyclic Aromatic Compounds: Synthesis, Properties, Analytical Measurements, Occurrence and Biological Effects (P. Garrigues and M. Lamotte, eds.) Gordon and Breach Science Publishers, Yverdon (Switzerland) (1993) pp 207 - 214
Synthesis and characterization of glutathione conjugates of diastereomeric bay- and fjord-region dihydrodiol epoxides.
Polycyclic Aromatic Compounds: Synthesis, Properties, Analytical Measurements, Occurrence and Biological Effects (P. Garrigues and M. Lamotte, eds.) Gordon and Breach Science Publishers, Yverdon (Switzerland) (1993) pp 207 - 214
Nr. 42Wameling, C., Glatt, H.R., Oesch, F., and Seidel, A.
Stereospecific synthesis of the diastereomeric "reverse" dihydrodiol epoxides of chrysene and picene.
Polycyclic Aromatic Compounds: Synthesis, Properties, Analytical Measurements, Occurrence and Biological Effects (P. Garrigues andM. Lamotte, eds.) Gordon and Breach Science Publishers, Yverdon (Switzerland) (1993) pp 191 - 198
Stereospecific synthesis of the diastereomeric "reverse" dihydrodiol epoxides of chrysene and picene.
Polycyclic Aromatic Compounds: Synthesis, Properties, Analytical Measurements, Occurrence and Biological Effects (P. Garrigues andM. Lamotte, eds.) Gordon and Breach Science Publishers, Yverdon (Switzerland) (1993) pp 191 - 198
Nr. 41Steinbrecher, T., Wameling, C., Oesch, F., and Seidel, A.
Activation of the C2 position of purine by the trifluoromethanesulfonate group: synthesis of N2-alkylated deoxyguanosines.
Angew. Chem. Int. Ed. Engl., 32 (1993) 404-406
Activation of the C2 position of purine by the trifluoromethanesulfonate group: synthesis of N2-alkylated deoxyguanosines.
Angew. Chem. Int. Ed. Engl., 32 (1993) 404-406
Nr. 40Steinbrecher, T., Wameling, C., Oesch, F., and Seidel, A.
Die Trifluormethan- sulfonatfunktion als neue Aktivierung der C-2-Position am Purin: Synthese von N2-alkylierten Deoxyguanosinen.
Angew. Chem., 105 (1993) 408-410
Die Trifluormethan- sulfonatfunktion als neue Aktivierung der C-2-Position am Purin: Synthese von N2-alkylierten Deoxyguanosinen.
Angew. Chem., 105 (1993) 408-410
Nr. 39Glatt, H.R., Wameling, C., Elsberg S., Thomas H., Marquardt H., Hewer A.,Phillips D.H., Oesch F., and Seidel, A.
Genotoxicity characteristics of prebay-region diol-epoxides of chrysene.
Carcinogenesis, 14 (1993) 11-19
Genotoxicity characteristics of prebay-region diol-epoxides of chrysene.
Carcinogenesis, 14 (1993) 11-19
1992
Nr. 38Bock, K.W., Gschaidmeier, H., Seidel, A., S. Baird, and Burchell, B.
Mono- and diglucuronide formation of chrysene and benzo[a]pyrene phenols by 3-methylcholanthrene-inducible phenol UDP-glucuronosyltransferase (UGT1A1).
Mol. Pharmacol., 42 (1992) 613-618
Mono- and diglucuronide formation of chrysene and benzo[a]pyrene phenols by 3-methylcholanthrene-inducible phenol UDP-glucuronosyltransferase (UGT1A1).
Mol. Pharmacol., 42 (1992) 613-618
Nr. 37Jernström, B., Seidel, A., Funk, M., Oesch, F., and Mannervik, B.
Glutathione conjugation of trans-3,4-dihydroxy 1,2-epoxy 1,2,3,4-tetrahydrobenzo[c]phenanthrene isomers by human glutathione transferases.
Carcinogenesis, 13 (1992) 1549-1555
Glutathione conjugation of trans-3,4-dihydroxy 1,2-epoxy 1,2,3,4-tetrahydrobenzo[c]phenanthrene isomers by human glutathione transferases.
Carcinogenesis, 13 (1992) 1549-1555
Nr. 36Wölfel, C., Heinrich-Hirsch, B., Schulz-Schalge, T., Seidel, A., Frank, H., Ramp, U., Wächter, F., Wiebel, F. J., Gonzalez, F., Greim, H., and Doehmer, J.
Genetically engineered V79 chinese hamster cells for stable expression of human cytochrome P450IA2.
Eur. J. Pharmacol. - Environ. Toxicol. Pharmacol. Sec., 228 (1992) 95-102
Genetically engineered V79 chinese hamster cells for stable expression of human cytochrome P450IA2.
Eur. J. Pharmacol. - Environ. Toxicol. Pharmacol. Sec., 228 (1992) 95-102
Nr. 35Klein, J., Post, K., Seidel, A., Frank, H., Oesch, F., and Platt, K.L.
Quinone reduction and redox cycling catalysezed by purified rat liver dihydrodiol/3a-hydroxysteroid dehydrogenase.
Biochem. Pharmacol., 44 (1992) 341-349
Quinone reduction and redox cycling catalysezed by purified rat liver dihydrodiol/3a-hydroxysteroid dehydrogenase.
Biochem. Pharmacol., 44 (1992) 341-349
Nr. 34Doehmer, J., Janssens, C., Dogra, S., Doehmer, C., Seidel, A., Platt, K.-L., Oesch, F., and Glatt, H.R.
Application of stable V79 derived cell lines expressing rat cytochromes P450IAI, IA2, and IIB1.
Xenobiotica, 22 (1992) 1093-1099
Application of stable V79 derived cell lines expressing rat cytochromes P450IAI, IA2, and IIB1.
Xenobiotica, 22 (1992) 1093-1099
Nr. 33Phillips, D.H., Hewer, A., Seidel, A., Steinbrecher, T., Schrode, R., Oesch, F., and Glatt, H.R.
Relationship between mutagenicity and DNA adduct formation in mammalian cells for fjord- and bay-region diol-epoxides of polycyclic aromatic hydrocarbons.
Chem.-Biol. Interactions, 80 (1992) 177-186
Relationship between mutagenicity and DNA adduct formation in mammalian cells for fjord- and bay-region diol-epoxides of polycyclic aromatic hydrocarbons.
Chem.-Biol. Interactions, 80 (1992) 177-186
1991
Nr. 32Klein, J., Seidel, A., Frank, H., Oesch, F., and Platt, K.L.
Regiospecific oxidation of polycyclic aromatic dihydrodiols by rat liver dihydrodiol dehydrogenase.
Chem.-Biol. Interactions, 79 (1991) 287-303
Regiospecific oxidation of polycyclic aromatic dihydrodiols by rat liver dihydrodiol dehydrogenase.
Chem.-Biol. Interactions, 79 (1991) 287-303
Nr. 31Doehmer, J., Dogra, S., Janssens, C., Edigkaufer, M., Seidel, A., Glatt, H.R., Platt, K.-L., and Oesch, F.
Die gentechnologische Konstruktion von V79 Chinesischen Hamsterzellen zur stabilen Expression von Fremdstoff-metabolisierenden Enzymen und ihre Anwendung in Metabolismus- und Mutagenitäts-Studien von Pharmaka und anderen Fremdstoffen.
Alternativen zu Tierexperimenten, 8 (1991) 52 - 64
Die gentechnologische Konstruktion von V79 Chinesischen Hamsterzellen zur stabilen Expression von Fremdstoff-metabolisierenden Enzymen und ihre Anwendung in Metabolismus- und Mutagenitäts-Studien von Pharmaka und anderen Fremdstoffen.
Alternativen zu Tierexperimenten, 8 (1991) 52 - 64
Nr. 30Seidel, A., Bochnitschek, W., Glatt, H.R., Hodgson, R.M., Grover, P.L., and Oesch, F.
Activated Metabolites of chrysene: Synthesis of 9-Hydroxychrysene-1,2-diol and the corresponding bay-region syn- and anti-triol-epoxides.
Polynuclear Aromatic Hydrocarbons: Measurements, Means and Metabolism (ed's. M. Cooke, K. Loening and J. Meritt), Battelle Press, Columbus, OH (1991) pp 801 - 817
Activated Metabolites of chrysene: Synthesis of 9-Hydroxychrysene-1,2-diol and the corresponding bay-region syn- and anti-triol-epoxides.
Polynuclear Aromatic Hydrocarbons: Measurements, Means and Metabolism (ed's. M. Cooke, K. Loening and J. Meritt), Battelle Press, Columbus, OH (1991) pp 801 - 817
Nr. 29Ludewig, G., Dogra, S., Seidel, A., Setiabudi, F., Oesch, F., and Glatt, H.R.
Quinones derived from polycyclic aromatic hydrocarbons: Induction of diverse mutagenic and genotoxic effects in mammalian cells.
Polynuclear Aromatic Hydrocarbons: Measurements, Means and Metabolism (ed's. M. Cooke, K. Loening and J. Meritt), Battelle Press, Columbus, OH (1991) pp 545 - 556
Quinones derived from polycyclic aromatic hydrocarbons: Induction of diverse mutagenic and genotoxic effects in mammalian cells.
Polynuclear Aromatic Hydrocarbons: Measurements, Means and Metabolism (ed's. M. Cooke, K. Loening and J. Meritt), Battelle Press, Columbus, OH (1991) pp 545 - 556
Nr. 28Glatt, H. R., Seidel, A., Schrode, R., Ribeiro, O., Kirkby, C. A., Hirom, P. C., and Oesch, F.
3-Hydroxybenzo[a]pyrene-7,8-dihydrodiol compared with benzo[a]pyrene-7,8-dihydrodiol and 3-hydroxybenzo[a]pyrene with regard to muta-genicity.
Polynuclear Aromatic Hydrocarbons: Measurements, Means and Metabolism (ed's. M. Cooke, K. Loening and J. Meritt), Battelle Press, Columbus, OH (1991) pp 357 - 368
3-Hydroxybenzo[a]pyrene-7,8-dihydrodiol compared with benzo[a]pyrene-7,8-dihydrodiol and 3-hydroxybenzo[a]pyrene with regard to muta-genicity.
Polynuclear Aromatic Hydrocarbons: Measurements, Means and Metabolism (ed's. M. Cooke, K. Loening and J. Meritt), Battelle Press, Columbus, OH (1991) pp 357 - 368
Nr. 27Glatt, H.R., Piée A., Pauly K., Steinbrecher, T., Schrode R., Oesch, F. and Seidel, A.
Fjord- and bay-region diol-epoxides investigated on stability, SOS induction in Escherichia coli, and mutagenicity in Salmonella typhimurium and mammalian cells.
Cancer Res, 51 (1991) 1659-1667
Fjord- and bay-region diol-epoxides investigated on stability, SOS induction in Escherichia coli, and mutagenicity in Salmonella typhimurium and mammalian cells.
Cancer Res, 51 (1991) 1659-1667
1990
Nr. 26Hradec, J., Seidel, A., Platt, K.L., Glatt, H.R., Oesch, F., and Koblyakov, V.
The Initiator tRNA acceptance assay as a short-term test for carcinogens. 6. Results with 78 polycyclic aromatic compounds.
Carcinogenesis, 11 (1990) 1921-1926
The Initiator tRNA acceptance assay as a short-term test for carcinogens. 6. Results with 78 polycyclic aromatic compounds.
Carcinogenesis, 11 (1990) 1921-1926
Nr. 25Steinberg, P., Schlemper, B., Molitor, E., Platt, K.L., Seidel, A., and Oesch, F.
Rat liver Kupffer and endothelial cell-mediated mutagenicity of polycyclic aromatic hydrocarbons and aflatoxin B1.
Environ. Health Perspect., 88 (1990) 71-76
Rat liver Kupffer and endothelial cell-mediated mutagenicity of polycyclic aromatic hydrocarbons and aflatoxin B1.
Environ. Health Perspect., 88 (1990) 71-76
Nr. 24Doehmer, J., Seidel, A., Oesch, F., and Glatt, H.R.
Genetically-engineered V79 chinese hamster cells metabolically activate the cytostatic drugs cyclophosphamide and ifosfamide.
Environ. Health Perspect., 88 (1990) 63-65
Genetically-engineered V79 chinese hamster cells metabolically activate the cytostatic drugs cyclophosphamide and ifosfamide.
Environ. Health Perspect., 88 (1990) 63-65
Nr. 23Glatt, H.R., Henschler, R., Phillips, D. H., Blake, J. W., Steinberg, P., Seidel, A., and Oesch, F.
Sulfotransferase-mediated chlorination of 1-hydroxymethylpyrene to a mutagen capable of penetrating into indicator cells.
Environ. Health Perspect., 88 (1990) 43-48
Sulfotransferase-mediated chlorination of 1-hydroxymethylpyrene to a mutagen capable of penetrating into indicator cells.
Environ. Health Perspect., 88 (1990) 43-48
Nr. 22Masento, M.S., Taylor, G.W., Watson, D., Seidel, A., Bochnitschek, W., Oesch, F., and Grover, P.L.
Metabolism of 3-hydroxychrysene by rat liver microsomal preparations.
Chem.-Biol. Interactions, 74 (1990) 163-178
Metabolism of 3-hydroxychrysene by rat liver microsomal preparations.
Chem.-Biol. Interactions, 74 (1990) 163-178
Nr. 21Dogra, S., Doehmer, J., Glatt, H.R., Siegert, P., Friedberg, T., Seidel, A., and Oesch, F.
Stable expression of rat P450IA1 cDNA in V79 Chinese hamster cells and their use in mutagenicity testing.
Mol. Pharmacol., 37 (1990) 608-613
Stable expression of rat P450IA1 cDNA in V79 Chinese hamster cells and their use in mutagenicity testing.
Mol. Pharmacol., 37 (1990) 608-613
Nr. 20Seidel, A., Glatt, H.R., Oesch, F., and Garrigues, P.
2,9-Dimethylpicene: Synthesis, mutagenic activity, and identification in natural samples.
Polycycl. Arom. Compds., 1 (1990) 3-14
2,9-Dimethylpicene: Synthesis, mutagenic activity, and identification in natural samples.
Polycycl. Arom. Compds., 1 (1990) 3-14
1989
Nr. 19Knepper T., Lenhardt, S., Przybylski, M., Bosk, C., Platt, K.L., Seidel, A., and Oesch, F.
Identification and structural characterization of mono- and bis- glutathionyl conjugates from polyaromatic quinone metabolites.
Advances in Mass Spectrometry (ed. P. Longevialle), Vol. 11B (Proceedings of the 11th International Mass Spectrometry Conference held at Bordeaux 29. August - 2. September 1988), Heydon & Son, London (1989) pp 1398 - 1399
Identification and structural characterization of mono- and bis- glutathionyl conjugates from polyaromatic quinone metabolites.
Advances in Mass Spectrometry (ed. P. Longevialle), Vol. 11B (Proceedings of the 11th International Mass Spectrometry Conference held at Bordeaux 29. August - 2. September 1988), Heydon & Son, London (1989) pp 1398 - 1399
Nr. 18Doehmer, J., Dogra, S., Edigkaufer, M., Molitor, E., Siegert, P., Friedberg, T., Glatt, H.R., Platt, K.L., Seidel, A., Thomas, H., and Oesch, F.
Introduction of cytochrome P-450 genes into V79 Chinese hamster cells to generate new mutagenicity test systems.
Arch. Toxicol., Suppl., 13 (1989) 164 - 168
Introduction of cytochrome P-450 genes into V79 Chinese hamster cells to generate new mutagenicity test systems.
Arch. Toxicol., Suppl., 13 (1989) 164 - 168
1988
Nr. 17Glatt, H.R., Hirom, P.C., Kirkby, C.A., Ribeiro, O., Seidel, A., and Oesch, F.
Complex metabolic activation pathways of polycyclic aromatic hydrocarbons: 3-Hydroxy-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene as a proximate mutagen of 3-hydroxybenzo[a]pyrene.
Chemical Carcinogenesis (eds. F. Feo, P. Pani, A. Columbano, and R. Garcea), Plenum Publishing Corporation, New York (1988) pp 37 - 44
Complex metabolic activation pathways of polycyclic aromatic hydrocarbons: 3-Hydroxy-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene as a proximate mutagen of 3-hydroxybenzo[a]pyrene.
Chemical Carcinogenesis (eds. F. Feo, P. Pani, A. Columbano, and R. Garcea), Plenum Publishing Corporation, New York (1988) pp 37 - 44
Nr. 16Platt, K.L., Petrovic, P., Seidel, A., Beermann, D., and Oesch, F.
Microsomal metabolism of picene.
Chem.-Biol. Interactions, 66 (1988) 157-175
Microsomal metabolism of picene.
Chem.-Biol. Interactions, 66 (1988) 157-175
Nr. 15Heidmann, M., Fonrobert, P., Przybylski, M., Platt, K.L., Seidel, A., and Oesch, F.
Conjugation reactions of polyaromatic quinones to mono- and bisglutathionyl adducts: Direct analysis by fast atom bombardment mass spectrometry.
Biomed. Environm. Mass Spectrometry, 15 (1988) 329-332
Conjugation reactions of polyaromatic quinones to mono- and bisglutathionyl adducts: Direct analysis by fast atom bombardment mass spectrometry.
Biomed. Environm. Mass Spectrometry, 15 (1988) 329-332
1987
Nr. 14Hodgson, R.M., Seidel, A., Bochnitschek, W., Glatt, H.R., Oesch, F., and Grover, P. L.
Formation of glutathion conjugates from chrysene diol- and triol-epoxides: Evidence for the further metabolism of the “bay-region” diol-epoxide of chrysene to a triol-epoxide. In: Glutathione S -Transferases and Carcinogenesis (eds. T.J. Mantle, C.B. Pickett, and J.D. Hayes)
Taylor & Francis, London (1987) pp 239 - 243
Formation of glutathion conjugates from chrysene diol- and triol-epoxides: Evidence for the further metabolism of the “bay-region” diol-epoxide of chrysene to a triol-epoxide. In: Glutathione S -Transferases and Carcinogenesis (eds. T.J. Mantle, C.B. Pickett, and J.D. Hayes)
Taylor & Francis, London (1987) pp 239 - 243
Nr. 13Glatt, H.R., Seidel, A., Ribeiro, O., Kirkby, C., Hirom, P., and Oesch, F.
Metabolic activation to a mutagen of 3-hydroxy-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene, a secondary metabolite of benzo[a]pyrene.
Carcinogenesis, 8 (1987) 1621-1627
Metabolic activation to a mutagen of 3-hydroxy-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene, a secondary metabolite of benzo[a]pyrene.
Carcinogenesis, 8 (1987) 1621-1627
1986
Nr. 12Glatt, H.R., Henschler, R., Klein, J., Ludewig, G., Martiné, U., Pauly, K., Piée, A., Platt, K.L., Seidel, A., Setiabudi, S. and Utesch, D.
Multiple activation pathways of both benzene and polycyclic aromatic hydrocarbons leading to products with varying cytotoxic and genotoxic characteristics. In: Primary Changes and Control Factors in Carcinogenesis (eds. T. Friedberg, and F. Oesch)
Deutscher Fach-schriften-Verlag, Wiesbaden (Germany) (1986) pp 55 - 59
Multiple activation pathways of both benzene and polycyclic aromatic hydrocarbons leading to products with varying cytotoxic and genotoxic characteristics. In: Primary Changes and Control Factors in Carcinogenesis (eds. T. Friedberg, and F. Oesch)
Deutscher Fach-schriften-Verlag, Wiesbaden (Germany) (1986) pp 55 - 59
Nr. 11Hodgson, R. M., Weston, A., Seidel, A., Bochnitschek, W., Glatt, H. R., Oesch, F., and Grover, P. L.
Metabolism of chrysene to triols and a triol-epoxide in mouse skin and rat liver preparations.
Polynuclear Aromatic Hydrocarbons: Chemistry, Characterization and Carcinogenesis (eds. M. Cooke, and A. J. Dennis), Battelle Press, Columbus, OH (1986) pp. 387 - 399
Metabolism of chrysene to triols and a triol-epoxide in mouse skin and rat liver preparations.
Polynuclear Aromatic Hydrocarbons: Chemistry, Characterization and Carcinogenesis (eds. M. Cooke, and A. J. Dennis), Battelle Press, Columbus, OH (1986) pp. 387 - 399
Nr. 10Glatt, H. R., Seidel, A., Bochnitschek, W., Marquardt, H., Marquardt, H., Hodgson, R. M., Grover, P. L., and Oesch, F.
Mutagenicity in bacterial and mammalian cells of diol-epoxides, triol-epoxides and other metabolites of chrysene.
Polynuclear Aromatic Hydrocarbons: Chemistry, Characterization and Carcinogenesis (eds. M. Cooke , and A. J. Dennis), Battelle Press, Columbus, OH (1986) pp. 343 - 358
Mutagenicity in bacterial and mammalian cells of diol-epoxides, triol-epoxides and other metabolites of chrysene.
Polynuclear Aromatic Hydrocarbons: Chemistry, Characterization and Carcinogenesis (eds. M. Cooke , and A. J. Dennis), Battelle Press, Columbus, OH (1986) pp. 343 - 358
Nr. 9Hodgson, R.M., Seidel, A., Bochnitschek, W., Glatt, H.R., Oesch, F., and Grover, P.L.
Metabolism of the bay-region diol-epoxide of chrysene to a triol-epoxide and the enzyme-catalysed conjugation of these epoxides with glutathione.
Carcinogenesis, 7 (1986) 2095-2098
Metabolism of the bay-region diol-epoxide of chrysene to a triol-epoxide and the enzyme-catalysed conjugation of these epoxides with glutathione.
Carcinogenesis, 7 (1986) 2095-2098
Nr. 8Phillips, D.H., Glatt, H.R., Seidel, A., Bochnitschek, W., Oesch, F., and Grover, P.L.
Mutagenic potential and DNA adducts formed by diol-epoxides, triol-epoxides and K-region epoxides of chrysene in mammalian cells.
Carcinogenesis, 7 (1986) 1739-1743
Mutagenic potential and DNA adducts formed by diol-epoxides, triol-epoxides and K-region epoxides of chrysene in mammalian cells.
Carcinogenesis, 7 (1986) 1739-1743
Nr. 7Glatt, H.R., Seidel, A., Bochnitschek, W., Marquardt, H., Marquardt, H., Hodgson, R.M., Grover, P.L., and Oesch, F.
Mutagenic and cell-transforming activities of triol-epoxides as compared to other chrysene metabolites.
Cancer Res., 46 (1986) 4556-4565
Mutagenic and cell-transforming activities of triol-epoxides as compared to other chrysene metabolites.
Cancer Res., 46 (1986) 4556-4565
Nr. 6Wermuth, B., Platt, K. L., Seidel, A., and Oesch, F.
Carbonyl reductase provides the enzymatic basis of quinone detoxication in man. Biochem.
Pharmacol., 35 (1986) 1277-1282
Carbonyl reductase provides the enzymatic basis of quinone detoxication in man. Biochem.
Pharmacol., 35 (1986) 1277-1282
1985
Nr. 5Hodgson, R. M., Seidel, A., Bochnitschek, W., Glatt, H.R., Oesch, F., and Grover, P.L.
The formation of 9-hydroxychrysene-1,2-diol as an intermediate in the metabolic activation of chrysene.
Carcinogenesis, 6 (1985) 135-139
The formation of 9-hydroxychrysene-1,2-diol as an intermediate in the metabolic activation of chrysene.
Carcinogenesis, 6 (1985) 135-139
Nr. 4Bochnitschek, W., Seidel, A., Kunz, H., and Oesch, F.
Reactive metabolites of carcinogenic polycyclic hydrocarbons: Synthesis and trapping reaction of 9-hydroxybenzo[a]pyrene 4,5-oxide
Angew. Chem. Int. Ed. Engl., 24 (1985) 699-700
Reactive metabolites of carcinogenic polycyclic hydrocarbons: Synthesis and trapping reaction of 9-hydroxybenzo[a]pyrene 4,5-oxide
Angew. Chem. Int. Ed. Engl., 24 (1985) 699-700
Nr. 3Bochnitschek, W., Seidel, A., Kunz, H., and Oesch, F.
Reaktive Metabolite cancerogener polycyclischer Kohlenwasserstoffe: Synthese und Abfangreaktion von 9-Hydroxy-benzo[a]pyren-4,5-oxid
, 97 (1985) 703-704
Reaktive Metabolite cancerogener polycyclischer Kohlenwasserstoffe: Synthese und Abfangreaktion von 9-Hydroxy-benzo[a]pyren-4,5-oxid
, 97 (1985) 703-704
1984
Nr. 2Oesch, F., Glatt, H. R., Vogel, K., Seidel, A., Petrovic, P., and Platt, K. L.
Dihydrodiol dehydrogenase: A new level of control by both sequestration of proximate and inactivation of ultimate carcinogens.
Biochemical Basis of Chemical Carcinogenesis (eds. H. Greim, R. Jung, M. Kramer, H. Marquardt, and F. Oesch) Raven Press, New York, pp. 23 - 31 (1984)
Dihydrodiol dehydrogenase: A new level of control by both sequestration of proximate and inactivation of ultimate carcinogens.
Biochemical Basis of Chemical Carcinogenesis (eds. H. Greim, R. Jung, M. Kramer, H. Marquardt, and F. Oesch) Raven Press, New York, pp. 23 - 31 (1984)
Nr. 1Beermann, D., Petrovic, P., Seidel, A., and Oesch, F.
A facile microsynthesis of 14C-labelled picene.
J. Labelled Compds. Radiopharm., 21 (1984) 781-787
A facile microsynthesis of 14C-labelled picene.
J. Labelled Compds. Radiopharm., 21 (1984) 781-787