Publikationen

2016

Nr. 257

Wohak, L.E., Krais, A.M., Kucab, J.E., Stertmann, J., Ovrebo, S., Seidel, A., Phillips, D.H. Arlt, V.M.
Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism.
Arch. Toxicol., 90 (2016) 291-304

Nr. 256

Sachse, B., Walter Meinl, W., Sommer, Y., Glatt, H.R., Seidel, A., Monien, B.H.
Bioactivation of suspected food carcinogens 5-hydroxymethylfurfural and furfuryl alcohol by sulfotransferases from human, mouse and rat: a comparative study.
Arch. Toxicol., 90 (2016) 137-148

Nr. 255

Krais, A.M., Speksnijder, E.N., Melis, J.P.M., Indra, R., Moserova, M., Godschalk, R.W., van Schooten, F.-J., Seidel, A., Schmeiser, H.H., Stiborova, M., Phillips, D.H., Luijten M., and Arlt, V.M.
The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/-) and Trp53(-/-) mice.
Arch. Toxicol., 90 (2016) 839-851

Nr. 254

Völkel, W., Kiranoglu, M., Dettbarn, G., Jessel, S., Seidel, A., Fromme, H.
Toxicokinetic of Di-(isononyl)-cyclohexane-1,2-dicarboxylate (DINCH®) in humans following single oral administration.
Tox. Lett., 248 (2016) 16-24

Nr. 253

Schreck, I., Grico, N., Hansjosten, I., Marquardt, C., Bormann, S., Seidel, A., Kvietkova, D. L., Pieniazek, D., Segerbäck, D., Diabate, S., van der Horst, G. T., Oesch-Bartlomowicz, B., Oesch, F., Weiss, C.
The nucleotide excision repair protein XPC is essential for bulky DNA adducts to promote interleukin 6 expression via activation of p38-SAPK.
Oncogene, 35 (2016) 908-918

2015

Nr. 252

Waizenegger, J., Lenze, D., Luckert, C., Seidel, A., Lampen, A., Hessel, S.
Dose-dependent induction of signaling pathways by the flavonoid quercetin in human primary hepatocytes: a transcriptomic study
Mol. Nutr. Food Res, 59 (2015) 1117-1129

Nr. 251

Ehlers, A., Florian, S., Schumacher, F., Meinl, H., Lenze, D., Hummel, M., Heise, T., Seidel, A., Glatt, HR., Lampen, A.
The glucosinolate metabolite 1-methoxy-3-indolyl­methyl alcohol induces a gene expression profile in mouse liver similar to the expression signature caused by known genotoxic hepatocarcinogens.
Mol. Nutr. Food Res, 59 (2015) 685-697

2014

Nr. 250

Wohak, L.U.E., Krais, A.M., Kucab, J.E., Stertmann, J., Øvrebø, S., Seidel, A., Phillips, D.H., and Arlt, V.M.
Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53 dependent mechanism.
Arch. Toxicol., 90 (2014) 291-304

Nr. 249

Kranz, J., Hessel, S., Aretz, J., Seidel, A., Petzinger, E., Geyer, J., Lampen, A.
The role of the efflux carriers Abcg2 and Abcc2 for the hepatobiliary elimination of benzo[a]pyrene and its metabolites in mice.
Chem.-Biol. Interact, 224C (2014) 36-41

Nr. 248

Polanska, K., Dettbarn, G., Jurewicz, J., Sobala, W., Magnus, P., Seidel, A., Hanke, W.
Effect of prenatal polycyclic aromatic hydrocarbons exposure on birth outcomes: the Polish mother and child cohort study.
BioMed Research International, Article ID 408939, 10 pages, open access (2014)

Nr. 247

Polanska, K., Hanke, W., Dettbarn, G., Sobala, W., Gromadzinska, J., Magnus, P., Seidel, A.
Exposure of the Polish population to polycyclic aromatic hydrocarbons - a multiple urinary biomarker study among non-smoking pregnant women.
Sci. Total Environ., 487 (2014) 102-109

Nr. 246

Westberg, E., Hedebrant, U., Haglund, J., Alsberg, T., Eriksson, J., Seidel, A., Törnqvist, M.
Conditions for sample preparation and HPLC/MS-MS-analysis of bulky adducts to serum albumin with diolepoxides of polycyclic aromatic hydrocarbons as models.
Anal. Bioanal. Chem., 406 (2014) 1519-1530

Nr. 245

Schwarz, M., Behnke, A., Brandt, M., Eisenträger, A., Hassauer, M., Kalberlah, F., Seidel, A.
Semipolar polycyclic aromatic compounds: Identification of 15 priority substances and the need of regulatory steps under reach regulation.
Integr. Environ. Assess. Manag., 10 (2014) 415-428

Nr. 244

Schumacher, F., Florian, S., Schnapper, A., Monien, B. H., Mewis, I., Schreiner, M., Seidel, A., Engst, W., Glatt. H.
A secondary metabolite of Brassicales, 1-methoxy-3-indolylmethyl glucosinolate, as well as its degradation product, 1-methoxy-3-indolylmethyl alcohol, forms DNA adducts in the mouse, but in varying tissues and cells.
Arch. Toxicol., 88 (2014) 823-836

2013

Nr. 243

Hessel, S., Stumkat, L., Lampen, A., and Seidel, A.
Polycyclic aromatic hydrocarbons in food - Efflux of the conjugated biomarker 1-hydroxypyrene is mediated by Breast Cancer Resistance Protein (ABCG2) in human intestinal Caco-2 cells.
Food Chem. Toxicol., 62 (2013) 797-804

Nr. 242

Seidel, A., Steinberg, P.
Polycyclische aromatische Kohlenwasserstoffe (PAK) in Lebensmitteln – Analytische Methoden und gesetzliche Höchstmengen.
GIT Labor-Fachzeitschrift, 9 (2013) 550-555

Nr. 241

Luckert, C., Ehlers, A., Buhrke, T., Seidel, A., Lampen, A., and Hessel, S.
Polycyclic aromatic hydrocarbons stimulate human CYP3A4 promoter activity via PXR.
Toxciol Lett., 222 (2013) 180-188

Nr. 240

Stempin, S., Andres, S., Bumke Scheer, M., Rode, A., Nau, H., Seidel , A., and Lampen, A.
Valproic acid and its derivatives enhanced estrogenic activity but not androgenic activity in a structure dependent manner.
Reprod. Toxicol., 42C (2013) 49-57

Nr. 239

Seidel, A., Steinberg, P., Appel, K., Lampen, A., H.M. Bolt, und Koss, G.
Kohlenwasserstoffe.
Toxikologie (Marquardt, H., Schäfer, S., und Barth, H., Hrsg.) Wissenschaftliche Verlagsgesellschaft mbH (WVG), Stuttgart (2013) S. 593-659

Nr. 238

Seidel, A., Steinberg, P.
Acrolein aus Lebensmitteln – Analytische Erfassung der Humanbelastung.
GIT Labor-Fachzeitschrift, 4 (2013) 231-233

Nr. 237

Nilsson, R., Antić, R., Berni, A., Dallner, G., Dettbarn, G., Gromadzinska, J., Joksić, G., Lundin, C., Palitti, F., Prochazka, G., Rydzynski, K., Segerbäck, D., Souček, P., Michael Tekle, M., and Seidel, A.
Exposure to polycyclic aromatic hydrocarbons in women from Poland, Serbia, and Italy – Relation between PAH metabolite excretion, DNA damage, diet and genotype (the EU DIEPHY project).
Biomarkers, 18 (2013) 165-173

Nr. 236

Hessel, S., John, A., Seidel, A., and Lampen, A.
Multidrug resistance-associated proteins are involved in the transport of the glutathione conjugates of the ultimate carcinogen of benzo[a]pyrene in human Caco-2 cells.
Arch. Toxicol, 87 (2013) 269-280

2012

Nr. 235

Schumacher, F., Engst, W., Monien, B.H., Florian, S., Schnapper, A., Steinhauser, L., Albert, K., Frank, H., Seidel, A., and Glatt, H.
Detection of DNA adducts originating from 1-methoxy-3-indolylmethyl glucosinolate using isotope-dilution UPLC-ESI-MS/MS.
Anal. Chem., 84 (2012) 6256-6262

Nr. 234

Monien, B.H., Engst, W., Barknowitz, G., Seidel, A., and Glatt, H.
Mutagenicity of 5-hydroxymethylfurfural in V79 cells expressing human SULT1A1: Identification and mass spectrometric quantification of DNA adducts formed.
Chem. Res. Toxicol., 25 (2012) 1484-1492

Nr. 233

John, A., Hessel, S., Lampen, A., and Seidel, A.
Analysis of GSH conjugates of bay- and fjord-region dihydrodiol epoxides of benzo[a]pyrene and dibenzo[a,l]pyrene and their transport in enterocyte-like Caco-2 cells.
Polycycl. Arom. Compds., 32 (2012) 221-237

2011

Nr. 232

Roelofzen, J.H., van der Valk, P.G., Godschalk, R., Dettbarn, G., Seidel, A., Golsteijn, L., Anzion, R., Aben, K.K., van Schooten, F.J., Kiemeney, L.A., Scheepers, P.T.
DNA adducts in skin biopsies and 1-hydroxypyrene in urine of psoriasis patients and healthy volunteers following treatment with coal tar.
Toxicol Lett., 213 (2011) 39-44

Nr. 231

Lagerqvist, A., Hakansson, D., Lundin, C., Prochazka, G., Dreij, K., Segerback, D., Jernstrom, B., Tornqvist, M., Frank, H., Seidel, A., Erixon, K. and Jenssen, D.
DNA repair and replication influence the number of mutations per adduct of polycyclic aromatic hydrocarbons in mammalian cells.
DNA Repair (Amst), 10 (2011) 877-886

Nr. 230

Schubert, J., Hahn, J., Dettbarn, G., Seidel, A., Luch, A., and Schulz, T.G.
Mainstream Smoke of the Waterpipe: Does This Environmental Matrix Reveal As Significant Source of Toxic Compounds?
Toxicol. Lett., 205 (2011) 275-284

Nr. 229

Breuer, D., Hahn, J.-U., Höber, D., Emmel, Ch., Musanke, U., Rühl, R., Spickenheuer, A., Raulf-Heimsoth, M., Bramer, R., Seidel, A., Schilling, B., Heinze, E., Kendzia, B., Marczynski, B., Welge, P., Angerer, J., Brüning, Th., and Pesch, B.
Air sampling and determination of vapours and aerosols of bitumen and polycyclic aromatic hydrocarbons in hot mastic-asphalt applications.
Arch Toxicol, 85 (Suppl 1) (2011) S11-20

Nr. 228

Lichtenstein, N., Buchwald, K.E., Hennig, M., Bernards, M., Werner, S., Hahn, J.U., Assenmacher-Maiworm, H., Kreyenschmidt, M., Brodkorb, F., Dettbarn, G., Jacob, J., and Seidel, A.
Inhalative Exposition von Dachdeckern gegenüber 2-Naphthylamin und anderen krebserzeugenden aromatischen Aminen bei der Heißverarbeitung von teerhaltigen Klebemassen.
Gefahrstoffe – Reinhaltung der Luft, 71 (2011) 109-207

Nr. 227

Gminski, R., Decker, K., Heinz, C., Seidel, A., Konczol, M., Goldenberg, E., Grobety, B., Ebner, W., Giere, R. and Mersch-Sundermann, V.
Genotoxic effects of three selected black toner powders and their dimethyl sulfoxide extracts in cultured human epithelial A549 lung cells in vitro.
Environ. Mol. Mutagen., 52 (2011) 296-309

Nr. 226

Glatt, H., Baasanjav-Gerber, C., Schumacher, F., Monien, B.H., Frank, H., Seidel, A., and Engst, W.
1-Methoxy-3-indolylmethyl glucosinolate: mechanism of bioactivation to genotoxicants for bacteria and mammalian cells.
Chem.-Biol. Interact., 192 (2011) 81-86

2010

Nr. 225

Seidel, A.
Polyzyklische aromatische Kohlenwasserstoffe. In: ”Sicherheitsrelevante Stoffe in Lebensmitteln - Toxikologie - in der praktischen Qualitätssicherung“ (Steinberg, P. und Hamscher, G., Hrsg.)
Behr’s Verlag (2010) p. 91-117

Nr. 224

Lagerqvist, A., Håkansson, D., Erixon, K., Heinz Frank, Seidel, A., and Jenssen, D.
Structural requirements for mutation formation from polycyclic aromatic hydrocarbon dihydrodiol epoxides in their interaction with food chemopreventive compounds.
Food Chem. Toxicol., 49 (2010) 879-886

Nr. 223

Singh, R., Teichert, F., Seidel, A., Roach, J., Cordell, R., Cheng, M.-K., Frank, H., Steward, W.P., Manson M.M., and Farmer, P.B.
Development of a targeted adductomic method for the determination of polycyclic aromatic hydrocarbon DNA adducts using online column-switching liquid chromatography tandem mass spectrometry.
Rapid Commun. Mass Spectrom. , 24 (2010) 2329–2340

Nr. 222

Hessel, S., S., John, A., Seidel, A., Glatt, H., Lampen, A.
Effects of quercetin on the detoxification of the food contaminant benzo[a]pyrene in the human intestinal Caco-2 cell model, in “Risk Assessment of Phytochemicals in Food: Novel Approaches”
Deutsche Forschungsgemeinschaft (DFG) (G. Eisenbrand ed.), Wiley-VCH (2010) p. 404-411

2009

Nr. 221

Hessel, S., John, A., Seidel, A., Lampen, A.
All-trans retinoic acid induces breast cancer resistance protein expression in Caco-2 cells and enhances the transport of benzo[a]pyrene-3-sulfate
Toxicol. Lett., 189 (Suppl.) (2009) S228, F05

Nr. 220

Eder, C., Frankenberger, M., Stanzel, F., Seidel, A., Schramm, K.-W., Ziegler-Heitbrock, L., and Hofer Th.P.J.
Ultrafine Carbon particles down-regulate CYP1B1 expression in human monocytes.
Part Fibre Toxicol, 6 (2009) 27

Nr. 219

Monien, B.H., Müller, C., Bakhiya, N., Donath, C., Frank, H., Seidel, A., and Glatt, H.R.
Probenecid, an inhibitor of transmembrane organic anion transporters, alters tissue distribution of DNA adducts in 1-hydroxymethylpyrene-treated rats.
Toxicology., 262 (2009) 80-85

Nr. 218

Bakhiya, N., Monien, B., Frank, H., Seidel, A., and Glatt, H.R.
Renal organic anion transporters OAT1 and OAT3 mediate the cellular accumulation of 5-sulfooxy­methylfurfural, a reactive, nephrotoxic metabolite of the Maillard product 5-hydroxy­methylfurfural.
Biochem. Pharmacol., 78 (2009) 414-419

Nr. 217

Marczynski, B., Pesch, B., Wilhelm, M., Rossbach, B., Preuss, R., Hahn, J.-U., Rabstein, S., Raulf-Heimsoth, M., Seidel, A., Rihs, H.-P., Adams, A., Scherenberg, M., Erkes, A., Engelhardt, B., Straif, K., Käfferlein, H. U., Angerer, J., and Brüning, T.
Occupational Exposure to Polycyclic Aromatic Hydrocarbons and DNA Damage by Industry – A Nationwide Study in Germany.
Arch. Tox., 83 (2009) 947-957

Nr. 216

Monien, B.H., Frank, H., Seidel, A., and Glatt, H.
Conversion of the common food constituent, 5-hydroxymethylfurfural into a mutagenic and carcinogenic sulfuric acid ester in the mouse in vivo.
Chem Res. Toxicol., 22 (2009) 1123-1128

Nr. 215

Kuhn, K., Nowak, B., Behnke, A., Seidel, A., and Lampen, A.
Combined chemical and effect-directed analysis of polycyclic aromatic hydrocarbons in smoked pork.
Food Addit Contam., 26 (2009) 1104-1112

Nr. 214

Schreck, I., Chudziak, D., Schneider, S., Seidel, A., Platt, K.-L., Oesch, F., and Weiss, C.
Influence of aryl hydrocarbon- (Ah) receptor and genotoxins on DNA repair gene expression and cell survival of mouse hepatoma cells.
Toxicology, 259 (2009) 91-96

Nr. 213

Kabler, S.L., Seidel, A., Jacob, J., Doehmer, J., Morrow, C.S., and Townsend, A.J.
Protection by human glutathione S-transferase P1 against cytotoxicity by benzo[a]pyrene or benzo[a]pyrene-7,8-dihydrodiol enantiomers in bi-transgenic cell lines that co-express rat or human cytochrome P4501A1.
Chem.-Biol. Interact., 179 (2009) 240-246

2008

Nr. 212

Yagi, H., Frank, H., Seidel, A., and Jerina, D.M.
Revised assignment of absolute configuration of the cis- and trans-N6-deoxyadenosine adducts at C14 of (±)-11β,12α-dihydroxy-13α,14α-epoxy-11,12,13,14-tetrahydrodibenzo[a,l]pyrene by stereoselective synthesis.
Chem. Res. Toxicol., 21 (2008) 2379-2392

Nr. 211

Monien, B.H., Muller, C., Engst, W., Frank, H., Seidel, A. and Glatt, H.
Time course of hepatic 1-methylpyrene DNA adducts in rats determined by isotope dilution LC-MS/MS and 32P-postlabeling.
Chem. Res. Toxicol., 21 (2008) 2017-2025

Nr. 210

Lagerqvist, A., Håkansson, D., Prochazka, G., Lundin, C., Dreij, K., Segerbäck, D., Jernström, B., Törnqvist, M., Seidel, A., Erixon, K., and Jenssen, D.
Both replication bypass fidelity and repair efficiency influence the yield of mutations per target dose in intact mammalian cells induced by benzo[a]pyrene-diol-epoxide and dibenzo[a,l]pyrene-diol-epoxide.
DNA Repair., 7 (2008) 1202-1212

Nr. 209

Glatt, H., Rost, K., Frank, H., Seidel, A., and Kollock, R.
Detoxification of promutagenic aldehydes derived from methylpyrenes by human aldehyde dehydrogenases ALDH2 and ALDH3A1.
Arch. Biochem. Biophys., 477 (2008) 196-205

Nr. 208

Kuhn, K., Nowak, N., Klein, G., Behnke, A., Seidel, A., and Lampen, A.
Determination of polycyclic aromatic hydrocarbons in smoked pork by effect directed bioassay with confirmation by chemical analysis.
J. Food Protect., 71 (2008) 993-999

Nr. 207

Seidel, A., Spickenheuer, A., Straif, K., Rihs, H.-P., Marczynski, B., Scherenberg, M., Dettbarn, G., Angerer, J., Wilhelm, M., Brüning, T., Jacob, J., and Pesch, B.
New biomarkers of occupational exposure to polycyclic aromatic hydrocarbons.
J. Toxicol. Environ. Health, A 71 (2008) 1–12

Nr. 206

Kollock, R., Frank, H., Seidel, A., Meinl, W. and Glatt, H.
Oxidation of alcohols and reduction of aldehydes derived from methyl- and dimethylpyrenes by cDNA-expressed human alcohol dehydrogenases.
Toxicology, 245 (2008) 65-75

Nr. 205

Pääjärvi, G., Jernström, B., Seidel, A., and Stenius U.
Anti-diol epoxide of benzo[a]pyrene induces transient Mdm2 and p53 Ser15 phosphorylation, while anti-diol epoxide of dibenzo[a,l]pyrene induces a nontransient p53 Ser15 phosphorylation.
Mol Carcinog, 47 (2008) 301-309

Nr. 204

Mattsson, Å., Malmlöf, M, Seidel, A., Stenius, U., Jernström, B.
H2AX, Mdm2 and p53 phosphorylations are differently affected by bay- and fjord-region diol epoxides derived from carcinogenic polycyclic aromatic hydrocarbons.
Polycyclic Aromat. Compd., 28 (2008) 392–401

Nr. 203

Kollock, R., Meinl, W., Schneider, H., Batke, M., Frank, H., Seidel, A. and Glatt, H.
Efficient oxidation of promutagenic hydroxymethylpyrenes by cDNA-expressed human alcohol dehydrogenase ADH2 and its inhibition by various agents.
Biochem. Pharmacol., 75 (2008) 527-537

2007

Nr. 202

Pesch, B., Kappler, M., Straif, K., Marczynski, B., Preuss, R., Rossbach, B., Rihs, H.P., Weiss, T., Rabstein, S., Pierl, C., Scherenberg, M., Adams, A., Kafferlein, H.U., Angerer, J., Wilhelm, M., Seidel, A. and Bruning, T.
Dose-response modeling of occupational exposure to polycyclic aromatic hydrocarbons with biomarkers of exposure and effect.
Cancer Epidemiol. Biomarkers Prev., 16 (2007) 1863-1873

Nr. 201

Bakhiya, N., Batke, M., Laake, J., Monien, B.H., Frank, H., Seidel, A., Engst, W. and Glatt, H.
Directing role of organic anion transporters in the excretion of mercapturic acids of alkylated polycyclic aromatic hydrocarbons.
Drug Metab. Dispos., 35 (2007) 1824-1831

Nr. 200

Halter, R., Hansen, T., Seidel, A., Ziemann, C., and Borlak, J.
Importance of DNA-adduct formation and gene expression profiling of disease candidate genes in rats exposed to bitumen fumes.
J. Occup. Environ. Hyg, 4 (Suppl 1) (2007) 44-64

Nr. 199

Yagi, H., Frank, H., Seidel, A., and Jerina, D.M.
Synthesis and absolute configuration of cis and trans opened cyclopenta[cd]pyrene 3,4-oxide N2-deoxyguanosine adducts: conversion to phosphoramidites for oligonucleotide synthesis.
Chem. Res. Toxicol., 20 (2007) 650-661

Nr. 198

Hansen, T., Seidel, A., and Borlak, J.
The environmental carcinogen 3-nitrobenzanthrone and its main metabolite 3-aminobenzanthrone induce production of reactive oxygen intermediates in human epithelial lung cells.
Toxicol Appl Pharmacol, 221 (2007) 222-234

Nr. 197

Glatt, H.R., Schneider, H., Seidel, A.
Polycyclische aromatische Kohlenwasserstoffe.
Handbuch der Lebensmitteltoxikologie (H. Dunkelberg, T. Gebel, A. Hartwig, eds.), Wiley-VCH Verlag, Weinheim (2007) 1121-1155

Nr. 196

Ebert, B., Seidel, A., and Lampen, A.
Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate.
Toxicol. Sci., 96 (2007) 227-236

Nr. 195

Rihs, H.-P., John, A., Scherenberg, M., Seidel, A., and Brüning, T.
Concordance between the deduced acetylation status generated by Real-time PCR based NAT2 genotyping of seven single nucleotide polymorphisms and human NAT2 phenotypes determined with caffeine.
Clinica Chim. Acta, 376 (2007) 240-243

2006

Nr. 194

Simon, R., Palme, S., Anklam E. and Collaborators: L. Delaire; V. Hanot; H. Holzer; W. Jira; C. Levasseur; F. Monteau; M.W. Obiedzinski; M. Ojala; D. Peschke; S. Ramakrishnan; C. Ranta; A. Ruthenschrör; M. Schirmacher; A. Seidel; P. Sopelana; G. Wolz; and C. Wright
Method Validation for Determination of the 15 European-Priority Polycyclic Aromatic Hydrocarbons in Primary Smoke Condensates by Gas Chromatography/Mass Spectrometry: Interlaboratory Study.
Journal of AOAC International, 89 (2006) 772-781

Nr. 193

Wang, B., Sayer, J.M., Yagi, H., Frank, H., Seidel, A., and Jerina, D.M.
Facile interstrand migration of the hydrocarbon moiety of a dibenzo[a,l]pyrene 11,12-diol 13,14-epoxide adduct at N2 of deoxyguanosine in a duplex oligonucleotide.
J. Am. Chem. Soc., 128 (2006) 10079-10084

Nr. 192

Schober, W., Luch, A., Soballa, V.J., Raab, G., Stegeman, J.J., Doehmer, J., Jacob, J. and Seidel, A.
On the species-specific biotransformation of dibenzo[a,l]pyrene.
Chem. Biol. Interact., 161 (2006) 37-48

Nr. 191

Bakhiya, N., Stephani, M., Seidel, A., Bahn, A., Ugele, B., Burckhardt, G. and Glatt, H.R.
Uptake of chemically reactive, DNA-damaging sulfuric acid esters into renal cells by human organic anion transporters.
J. Am. Soc. Nephrol., 17 (2006) 1414-1421

2005

Nr. 190

van Lipzig, M.M.H., Vermeulen, N.P.E., Gusino, R., Legler, J., Frank, H., Seidel. A. and Meerman, J.H.N.
Formation of estrogenic metabolites of benzo[a]pyrene and chrysene by cytochrome P450 activity and their combined and supra-maximal estrogenic activity.
Environ. Toxicol. Pharmacol., 19 (2005) 41-55

Nr. 189

Musafija-Jeknic, T., Luch, A., Seidel, A., Johns, C., Pereira, C., and Baird, W.M.
Effect of nucleotide sequence on the binding of (–)-anti-dibenzo[a,l]pyrene-11,12-diol 13,14-epoxide to short oligodeoxyribonucleotides.
Polycycl. Aromat. Compds., 25 (2005) 103-111

Nr. 188

Seidel, A.
Biomonitoring of PAHs - Human Exposure, in “The carcinogenic effects of polycyclic aromatic hydrocarbons” (Luch, A., ed.)
Imperial College Press (ICP), London (UK) (2005) p 97-136

Nr. 187

Ebert, B., Seidel, A., and Lampen, A.
Identification of BCRP as transporter of benzo[a]-pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists.
Carcinogenesis, 26 (2005) 1754-1763

Nr. 186

Ebert, B., Jacob, J., Seidel, A., and Lampen, A.
Oltipraz, flavone and indole-3-carbinol enhance the formation and transport of sulfate conjugates of benzo[a]pyrene in human enterocytes.
Tox. Lett., 157 (2005) 140-151

Nr. 185

Mensing, T., Marczynski, B., Engelhardt, B., Wilhelm, M., Preuss, R., Kappler, M., Angerer, J., Käfferlein, H.U., Scherenberg, M., Seidel, A., Brüning, T.
DNA adduct formation of benzo[a]pyrene in white blood cells of workers exposed to polycyclic aromatic hydrocarbons.
Int. J. Hyg. Environ. Health., 208 (2005) 173-178

Nr. 184

Rihs, H.-P., Pesch, B., Kappler, M., Rabstein, S., Roßbach, B., Angerer, J., Scherenberg, M., Adams, A., Wilhelm, M., Seidel, A., and Brüning, T.
Occupational exposure to polycyclic aromatic hydrocarbons in German industries: Association between ambient exposure and urinary metabolites and its modulation by enzyme polymorphisms.
Tox. Lett., 157 (2005) 241-255

Nr. 183

Dreij, K., Seidel, A., and Jernström, J.
Differential removal of DNA-adducts derived from anti-diol epoxides of dibenzo[a,l]pyrene and benzo[a]pyrene in human cells.
Chem Res. Toxicol., 18 (2005) 655-664

Nr. 182

Marczynski, B., Preuss, R., Mensing, T., Angerer, J., Seidel, A., El Mourabit, A., Wilhelm, M., and Brüning, T.
Genotoxic risk assessment in white blood cells of occupationally exposed workers before and after alteration of the polycyclic aromatic hydrocarbon (PAH) profile in the production material: comparison with PAH air and urinary metabolite levels.
Int Arch Occup Environ Health, 78 (2005) 98-108

2004

Nr. 181

Angerer, J., Roßbach, B., und Seidel, A.
Bestandsaufnahme zur Frage des Zusammenhangs zwischen dem DNA-Adduktgehalt in weißen Blutzellen und in humanem Lungengewebe.
Poly-cyclische aromatische Kohlenwasserstoffe – DFG Forschungsbericht (Jacob, J., und Greim, H., Hrsg.) WILEY-VCH Verlag GmbH & Co KGaA, (Weinheim) (2004) S. 77-117

Nr. 180

Seidel, A., Angerer, J.
Nukleobasen-Addukte von PAH im Humanurin.
Poly-cyclische aromatische Kohlenwasserstoffe – DFG Forschungsbericht (Jacob, J., und Greim, H., Hrsg.) WILEY-VCH Verlag GmbH & Co KGaA, (Weinheim) (2004) S. 70-76

Nr. 179

Jacob, J., Seidel, A.
Biomonitoring von PAH-Metaboliten im Humanurin.
Polycyclische aromatische Kohlenwasserstoffe – DFG Forschungsbericht (Jacob, J., und Greim, H., Hrsg.) WILEY-VCH Verlag GmbH & Co KGaA, (Weinheim) (2004) S. 42-69

Nr. 178

Jacob, J., Seidel, A.
Verwendung eines auf Wirkungsäquivalenten basierenden Summenparameters für die Abschätzung der PAH-Exposition und ihres Krebs erregenden Potentials.
Polycyclische aromatische Kohlenwasserstoffe – DFG Forschungsbericht (Jacob, J., und Greim, H., Hrsg.) WILEY-VCH Verlag GmbH & Co KGaA, (Weinheim) (2004) S. 8-22

Nr. 177

Seidel, A., Frank, H., Behnke, A., Schneider, D., and Jacob, J.
Determination of dibenzo[a,l]pyrene and other fjord-region PAH isomers with mw 302 in environmental samples.
Polycycl. Aromat. Compds., 24 (2004) 759-771

Nr. 176

Dreij, K., Bajak E., Sundberg K., Cotgreave I., Jernström. B., Seidel, A. and Gusnanto A.
DNA adducts of benzo[a]pyrene- and dibenzo[a,l]pyrene-diol epoxides in human lung epithelial cells: kinetics of adduct removal, effects on cell cycle checkpoints, and gene expression.
Polycycl. Aromat. Compds., 24 (2004) 549-566

Nr. 175

Päärjävi, G., Jernström. B., Stenius, U., and Seidel, A.
Exposure of mammalian cells to diol epoxides from benzo[a]pyrene and dibenzo[a,l]pyrene and effects on Mdm2 and p53.
Polycycl. Aromat. Compds., 24 (2004) 537-548

Nr. 174

Lampen, A., Ebert, B., Stumkat, L., Jacob, J., and Seidel, A.
Induction of gene expression of xenobiotic metabolism enzymes and ABC-transport proteins by PAH and a reconstituted PAH mixture in human Caco-2 cells.
Biochim. Biophys. Acta, 1681 (2004) 38-46

2003

Nr. 173

Wu, J., Wu, J., Zhu, B.B., Yu, J., Zhu, H., Qiu, L., Kindy, M.S., Gu, L., Seidel, A., Li, G.M.
In vitro and in vivo modulations of benzo[c]phenanthrene-DNA adducts by DNA mismatch repair system.
Nucleic Acids Res., 31 (2003) 6428-6434

Nr. 172

Arlt, V.M., Glatt, H.R., Muckel, E., Pabel, U., Sorg, B.L., Seidel, A., Frank, H., Schmeiser, H.H., and Phillips, D.H.
Activation of 3-nitrobenzanthrone and its metabolites by human acetyltransferases, sulfotransferases and cytochrome P450 expressed in Chinese hamster V79 cells.
Int. J. Cancer, 105 (2003) 583-592

Nr. 171

Mahadevan, B., Dashwood, W.-M., Luch, A., Pecaj, A., Doehmer, J., Seidel, A., and Baird, W.M.
Mutations induced by (–)-anti-11R,12S-dihydrodiol 13S,14R-epoxide of dibenzo[a,l]pyrene in the coding region of the hypoxanthine phosphoribosyltransferase (hprt) gene in Chinese hamster V79 cells.
Environ. Mol. Mutagen., 41 (2003) 131-139

Nr. 170

Arlt V.M., Bernd L. Sorg, B.L., Osborne, M., Hewer, A., Seidel, A., Schmeiser, H.H., and Phillips, D.H.
DNA adduct formation by the ubiquitous environmental pollutant 3-nitro-benzanthrone and its metabolites in rats.
Biochem. Biophys. Res. Commun., 300 (2003) 107-114

Nr. 169

Buesen, R., Mock, M., Nau, H., Seidel, A., Jacob, J., and Lampen, A.
Evidence for an active transport of polar [14C]-benzo[a]pyrene metabolites in human intestinal Caco-2 cells.
Chem.-biol. Interact., 142 (2003) 201-344

2002

Nr. 168

Buesen, R., Mock, M., Seidel, A., Jacob, J., and Lampen, A.
Interaction between metabolism and transport of benzo[a]pyrene and its metabolites in enterocytes.
Toxicol. Appl. Pharmacol., 183 (2002) 168-178

Nr. 167

Sundberg, K., Dreij, K., Jernström, B. and Seidel, A.
Detoxification of polycyclic aromatic hydrocarbon diol epoxides by human glutathione transferases: efficiency of conjugation in intact cells relative to purified enzymes.
Polycycl. Aromat. Compds., 22 (2002) 947-953

Nr. 166

Dreij, K., Sundberg, K., Jernström, B., Johansson, A.-S., Mannervik, B., and Seidel, A.
Inactivation of carcinogenic diol epoxides of dibenzo[a,l]pyrene (dibenzo[def,p]chrysene by human alpha class glutathione transferases.
Polycycl. Aromat. Compds., 22 (2002) 823-829

Nr. 165

Luch, A., Greim, H., Buters, J.T.M., Mahadevan, B., Baird, W.M., Doehmer, J., Seidel, A., and Glatt, H.R.
The role of cytochrome P450 1B1 in dibenzo[a,l]pyrene-induced carcinogenesis.
Polycycl. Aromat. Compds., 22 (2002) 781-789

Nr. 164

Baird, W.M., Hooven, L.A., Mahadevan, B., Luch, A., Seidel, A., Iversen, P.L.
Responses of human cells to PAH-induced DNA damage.
Polycycl. Aromat. Compds., 22 (2002) 771-780

Nr. 163

Jacob, J., Seidel, A.
Biomonitoring of polycyclic aromatic hydrocarbons (review)
J. Chromatogr. B, 778 (2002) 31-47

Nr. 162

Dreij, K., Sundberg, K., Johansson, A.-S., Nordling, E., Seidel, A., Persson, E., Mannervik, B., and Jernström, B.
Catalytic activities of human alpha class glutathione transferases towards carcinogenic dibenzo[a,l]pyrene diol epoxides.
Chem. Res. Toxicol., 15 (2002) 825-831

Nr. 161

Jacob, J., Seidel, A.
Zur Problematik der Verwendung von Benzo[a]pyren als Leitkomponente für das PAH-bedingte karzinogene Potential in Umweltmatrices
Gefahrstoffe - Reinhaltung der Luft, 62 (2002) 239-246

Nr. 160

Platt, K.-L., Degenhardt, C., Grupe, S., Frank, H., and Seidel, A.
Microsomal activation of anthanthrene, a hexacyclic aromatic hydrocarbon without a bay-region, to mutagenic metabolites.
Chem. Res. Toxicol., 15 (2002) 332-342

Nr. 159

Seidel, A., Dahmann, D., Krekeler, H., and Jacob, J.
Biomonitoring of polycyclic aromatic compounds in the urine of mining workers occupationally exposed to diesel-exhaust.
Inter. J. Hyg. Environ. Health, 204 (2002) 333-338

Nr. 158

Sundberg, K., Dreij, K., Seidel, A., and Jernström, B.
Glutathione conjugation and DNA adduct formation of dibenzo[a,l]pyrene and benzo[a]pyrene diol epoxides in V79 cells stably expressing different human glutathione transferases.
Chem. Res. Toxicol., 15 (2002) 170-179

Nr. 157

Schwerdtle, T., Seidel, A., and Hartwig, A.
Effect of soluble particulate nickel compounds on the formation and repair of stable benzo[a]pyrene DNA adducts in human lung cells.
Carcinogenesis, 23 (2002) 47-53

2001

Nr. 156

Seidel, A., Grimmer, G., Dettbarn, G., and Jacob, J.
Nachweis von kanzerogenen aromatischen Aminen im Harn von Nichtrauchern.
Umweltmed. Forsch. Prax., 6 (2001) 213-220

Nr. 155

Mahadevan, B., Luch, A., Seidel, A., Pelling, J.C., and Baird, W.M.
Effects of (–)-anti-11R,12S-dihydrodiol 13S,14R-epoxide of dibenzo[a,l]pyrene on DNA adduct formation and cell cycle arrest in human diploid fibroblasts.
Carcinogenesis, 22 (2001) 161-169

2000

Nr. 154

Ma, L., Landsiedel, R., Seidel, A., and Glatt, H.R.
Detection of mercapturic acids and nucleoside adducts in blood, urine and faeces of rats treated with 1-hydroxy-methylpyrene.
Polycycl. Arom. Compds., 21 (2000) 135-149

Nr. 153

Sundberg, K., Townsend, A., Luch, A., Seidel, A., and Jernström, B.
Effect of glutathione transferases on DNA-adduct formation of polycyclic aromatic hydrocarbons in mammalian cells.
Polycycl. Arom. Compds., 21 (2000) 123-133

Nr. 152

Jacob, J., Schober, W., Raab, G., Frank, H., Luch, A., Doehmer, J., and Seidel, A.
Species dependent metabolism of benzo[c]chrysene mediated by c-DNA-expressed human, rodent and fish cytochrome P450 enzymes.
Polycycl. Arom. Compds., 21 (2000) 109-121

Nr. 151

Luch, A., Schober, W., Greim, H., Doehmer, J., Jacob, J., Seidel, A., and Baird, W.M.
Metabolic activation of dibenzo[a,l]pyrene by cytochrome P450 enzymes to stable DNA adducts occurs exclusively through the formation of the (–)-trans-(11R,12R)-dihydrodiol.
Polycycl. Arom. Compds., 21 (2000) 87-98

Nr. 150

Borlak, J., Hansen, T., Yuan, X.Y., Sikka, H.C., Kumar, S., Schmidbauer, S., Raab, G., Frank, H., Jacob, J., and Seidel, A.
Metabolism and DNA binding of 3-nitrobenzanthrone in human fetal bronchial epithelial and alveolar typ II cells.
Polycycl. Arom. Compds., 21 (2000) 73-86

Nr. 149

Kroth, H., Yagi, H., Seidel, A., and Jerina, D.M.
New and highly efficient synthesis of cis- and trans-opened benzo[a]pyrene 7,8-diol 9,10-epoxide adducts at the exocyclic amino group of deoxyguanosine.
J. Org. Chem., 65 (2000) 5558-5564

Nr. 148

Doehmer, J., Krebsfänger, N., Schober, W., Luch, A., Buters, J.T.M., Jacob, J., Seidel, A., Mürdter, T., Zanger, U.M., and Eichelbaum, M.
Building a bio-technology platform for metabolism studies in pharmacology and toxicology.
Progress in the Reduction, Refinement and Replacement of Animal Experimentation, (Balls, M., van Zeller, A.-M., and Halder, M.E., ed's), Elsevier Science B.V. (2000) pp 139-146

Nr. 147

Buterin, T., Hess, M.T., Luneva, N., Geacintov, N.E., Amin, S., Kroth, H., Seidel, A., and Naegeli, H.
Unrepaired fjord region polycyclic aromatic hydrocarbon-DNA adducts in ras codon 61 mutational hot spots
Cancer Res., 60 (2000) 1849-1856

Nr. 146

Li, D.N., Seidel, A., Pritchard, M.P., Wolf, C.R., and Friedberg, T.
Polymorphisms in P450 CYP1B1 affect the conversion of estradiol to the potentially carcinogenic metabolite 4-hydroxyestradiol.
Pharmacogenetics, 10 (2000) 343-353

Nr. 145

Grimmer, G., Dettbarn, G., Seidel, A., and Jacob, J.
Detection of carcinogenic aromatic amines in the urine of non-smokers.
Sci. Total Environ., 247 (2000) 81-90

Nr. 144

Melendez-Colon, V.J., Luch, A., Seidel, A., and Baird, W.M.
Formation of stable DNA adducts and apurinic sites upon metabolic activation of bay and fjord region polycyclic aromatic hydrocarbons in human cell cultures.
Chem. Res. Toxicol., 13 (2000) 10-17

1999

Nr. 143

Sundberg, K., Seidel, A., Mannervik, B., and Jernström, B.
Catalytic efficiency of glutathione transferase P1-1 variants towards bay- and fjord-region diol epoxides of polycyclic aromatic hydrocarbons.
Polycycl. Aromat. Compds., 17 (1999) 43-51

Nr. 142

Pradhan, P., Gräslund, A., Seidel, A., and Jernström, B.
Studies on adduct formation of (+)-anti-benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide with the oligonucleotides 5'-d(CCTA TCGTTATCC) and 5'-d(CCTATCm5GTTATCC).
Polycycl. Aromat. Compds., 17 (1999) 21-32

Nr. 141

Jacob, J., Raab, G., Soballa, V.J., Luch, A., Grimmer, G., Greim, H., Doehmer, J., Morrison, H.G., Stegeman, J.J., and Seidel, A.
Species-dependent metabolism of benzo[c]phenanthrene and dibenzo[a,l]pyrene by various CYP450 isoforms.
Polycycl. Aromat. Compds., 16 (1999) 191-203

Nr. 140

Baird, W.M., Kaspin, L.C., Kudla, K., Seidel, A., Greim, H., and Luch, A.
Relationship of dibenzo[a,l]pyrene-DNA binding to the induction of p53, p21WAF1 and cell cycle arrest in human cells in culture.
Polycycl. Aromat. Compds., 16 (1999) 119-129

Nr. 139

Luch, A., Coffing, S.L., Seidel, A., Greim, H., Baird, W.M., and Doehmer, J.
DNA modification induced after metabolic activation of the potent carcinogen dibenzo[a,l]pyrene in V79 Chinese hamster cells stably expressing single cytochromes P450.
Polycycl. Aromat. Compds., 16 (1999) 71-78

Nr. 138

Pradhan, P., Gräslund, A., Seidel, A., and Jernström, B.
Implications of cytosine methylation on (+)-anti-benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide N2-dG adduct formation in 5'-d(CGT), 5'-d(CGA), and 5'-d(CGC) sequence contexts of single- and double-stranded oligonucleotides.
Chem. Res. Toxicol., 12 (1999) 816-821

Nr. 137

Luch, A., Kishiyama, S., Seidel, A., Doehmer, J., Greim, H., and Baird, W.M.
The K-region trans-8,9-diol does not significantly contribute as an intermediate in the metabolic activation of dibenzo[a,l]pyrene to DNA-binding metabolites by human cytochrome P450 1A1 or 1B1.
Cancer Res., 59 (1999) 4603-4609

Nr. 136

Li, K.-M., George, M., Gross, M.L., Lin, Ch.-H., Small, G.J., Jankowiak, R., Seidel, A., Kroth, H., Eleanor G. Rogan, E.L., and Cavalieri, E.L.
Structure elucidation of the adducts formed by fjord-region dibenzo[a,l]pyrene 11,12-diol 13,14-epoxides with deoxy­guanosine.
Chem. Res. Toxicol., 12 (1999) 778-788

Nr. 135

Li, K.-M., George, M., Gross, M.L., Seidel, A., Luch, A., Rogan, E.G., and Cavalieri, E.L.
Structure elucidation of the adducts formed by fjord-region dibenzo[a,l]pyrene 11,12-diol 13,14-epoxides with deoxyadenosine.
Chem. Res. Toxicol., 12 (1999) 758-767

Nr. 134

Pal, A., Seidel, A., Xia, H., Hu, X., Oesch, F., and Singh, S.V.
Specificity of murine glutathione S-transferase isozymes in the glutathione conjugation of (-)-anti- and (+)-syn-stereoisomers of benzo[g]chrysene 11,12-dihydrodiol 13,14-epoxide.
Carcinogenesis, 20 (1999) 1997-2001

Nr. 133

Melendez-Colon, V.J., Luch, A., Seidel, A., and Baird, W.M.
Cancer initiation by polycyclic aromatic hydrocarbons results from formation of stable DNA adducts rather than apurinic sites.
Carcinogenesis, 20 (1999) 1885-1891

Nr. 132

Pradhan, P., Jernström, B., Seidel, A., Nordén, B., and Gräslund, A.
Studies on the adduct heterogeneity of benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide stereo-isomers covalently bound to deoxyribooligonucleotides by induced circular dichroism and light absorption spectroscopy.
Chem. Res. Toxicol., 12 (1999) 403-411

Nr. 131

Bluvshtein, E., Glass, G.A., Volohonsky, G., Yaakubowitz, M., Harness, E., Smorodinsky, N., Seidel, A., Frank, H., Steinberg, P., and Stark, A.A.
Inhibition of the hydrolytic and transpeptidase activities of rat kidney g-glutamyl-transpeptidase by specific monoclonal antibodies.
Eur. J. Biochem., 260 (1999) 844-854

Nr. 130

Melendez-Colon, V.J., Luch, A., Seidel, A., and Baird, W.M.
Comparison of cytochrome P450 and peroxidase dependent metabolic activation of the potent carcinogen dibenzo[a,l]­pyrene in human cell lines: formation of stable DNA adducts and absence of a detectable increase in apurinic sites.
Cancer Res., 59 (1999) 1412-1416

Nr. 129

Luch, A., Friesel, H., Seidel, A., and Platt, K.L.
Tumor-initiating activity of the (+)-(S,S)- and (-)-(R,R)-enantiomers of trans-11,12-dihydroxy-11,12-dihydrodibenzo[a,l]pyrene in mouse skin.
Cancer Lett., 136 (1999) 119-128

Nr. 128

Luch, A., Schober, W., Soballa, V.J., Raab, G., Greim, H., Jacob, J., Doehmer, J. and Seidel, A.
Metabolic activation of dibenzo[a,l]pyrene by human cytochrome P450 1A1 and P450 1B1 expressed in V79 Chinese hamster cells.
Chem. Res. Toxicol., 12 (1999) 353-364

Nr. 127

Erb, C., Seidel, A., Frank, H., Platt, K.L., Oesch, F., and Klein, J.
Formation of N-methyl­nicotinamide in the brain from a dihydropyridine-type pro-drug: Effect on brain choline.
Biochem. Pharmacol., 57 (1999) 681-684

Nr. 126

Luch, A., Kudla, K., Seidel, A., Doehmer, J., Greim, H., and Baird, W.M.
The level of DNA modification by (+)-syn-(11S,12R,13S,14R)- and (-)-anti-(11R,12S,13S,14R)-dihydrodiol epoxides of dibenzo[a,l]pyrene determines the effect on the proteins p53 and p21WAF1 in the human mammary carcinoma cell line MCF-7.
Carcinogenesis, 20 (1999) 859-865

Nr. 125

Bock, K.W., Raschko, F.T., Gschaidmeier, H., Seidel, A., Oesch, F., Grove, A.D., Ritter, J.K.
Mono- and diglucuronide formation from benzo[a]pyrene and chrysene diphenols by AHH-1 cell-expressed UDP-glucuronosyltransferase UGT1A7.
Biochem. Pharmacol., 57 (1999) 653-656

Nr. 124

Doehmer, J., Buters, J.T.M., Luch, A., Soballa, V., Baird, W.M., Morisson, H., Stegeman, J.J., Townsend, A.J., Greenlee, W.F., Glatt, H.R., Seidel, A., Jacob, J., and Greim, H.
Molecular studies on the toxifying effects by genetically engeneered cytochromes P450.
Drug Met. Rev., 31 (1999) 423-435

1998

Nr. 123

Sundberg, K., Seidel, A., Mannervik, B. and Jernström, B.
Detoxification of carcinogenic fjord-region diol epoxides of polycyclic aromatic hydrocarbons by glutathione transferase P1-1 variants and glutathione.
FEBS Lett, 438 (1998) 206-210

Nr. 122

Seidel, A., Friedberg, T., Löllmann, B., Schwierzok, A., Funk, M., Frank, H., Holler, R., Oesch, F., and Glatt, H.R.
Detoxication of optically active bay- and fjord-region polycyclic aromatic hydrocarbon dihydrodiol epoxides by human glutathione transferase P1-1 expressed in Chinese hamster V79 cells.
Carcinogenesis, 19 (1998) 1975-1981

Nr. 121

Hu, X., Seidel, A., Frank, H., Srivastava, S.K., Xia, H., Pal, A., Zheng, S., Oesch, F., and Singh, S.V.
Differential enantioselectivity of murine glutathione S-transferase isoenzymes in the glutathione conjugation of trans-3,4-dihydroxy-1,2-oxy-1,2,3,4-tetrahydrobenzo[c]­phenanthrene stereoisomers.
Ach. Biochem. Biophys., 358 (1998) 40-48

Nr. 120

Landsiedel, R., Frank, H., Glatt, H.R., and Seidel, A.
Optical resolution of trans-dihydrodiol enantiomers of fjord-region polycyclic aromatic hydrocarbons by HPLC on a chiral cellulose-phase: relationship between elution order and absolute configuration.
J. Chromatogr. A, 822 (1998) 29-35

Nr. 119

Khan, Q.A., Agarwal, R., Seidel, A., Frank, H., Vousden, K.H., and Dipple, A.
Effects of optical isomers of benzo[g]chrysene anti dihydrodiol epoxide on passage of MCF-7 cells through the cell cycle.
Mol. Carcinog., 23 (1998) 115-120

Nr. 118

Luch, A., Schneider, A., Coffing, S. L., Soballa, V. J., Greim, H., Jefcoate, C.R., Greenlee, W.F., Seidel, A., Baird, W.M., and Doehmer, J.
Stable expression of human cytochrome P450 1B1 in V79 Chinese hamster cells and metabolically catalyzed DNA adduct formation of dibenzo[a,l]pyrene.
Chem. Res. Toxicol., 11 (1998) 686-695

Nr. 117

Jankowiak, R., Ariese, F., Hewer, A., Luch, A., Zamzow, D., Hughes, N.C., Phillips, D., Seidel, A., Platt, K.L., Oesch, F., and Small, G.J.
Structure, conformations, and repair of DNA adducts from dibenzo[a,l]pyrene: 32P-Postlabeling and fluorescence studies.
Chem. Res. Toxicol., 11 (1998) 674-685

Nr. 116

Landsiedel, R., Pabel, U., Engst, W., Ploschke, J., Seidel, A. and Glatt, H.R.
Chiral inversion of 1-hydroxymethylpyrene enantiomers mediated by enantioselective sulfotransferases.
Biochem. Biophys. Res. Commun., 247 (1998) 181-185

Nr. 115

Seidel, A., Soballa, V.J., Raab, G., Frank, H., Grimmer, G., Greim, H., Jacob, J., and Doehmer, J.
Regio- and stereoselectivity in the metabolism of benzo[c]phenanthrene mediated by genetically engineered V79 Chinese hamster cells expressing rat and human cytochromes P450.
Environ. Toxicol. Pharmacol., 5 (1998) 179-196

Nr. 114

Luch, A., Platt, K.L., and Seidel, A.
Synthesis of fjord region tetraols and their use in hepatic biotransformation studies of dihydrodiols of benzo[c]chrysene, benzo[g]chrysene and dibenzo[a,l]pyrene.
Carcinogenesis, 19 (1998) 639-648

Nr. 113

Pradhan, P., Jernström, B., Seidel, A., Nordén, B., and Gräslund, A.
Induced circular dichroism of benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide stereoisomers covalently bound to deoxyribooligonucleotides used to probe equilibrium distribution between groove binding and intercalative adduct conformations.
Biochemistry, 37 (1998) 4664-4673

Nr. 112

Glatt, H.R., Bartsch, I., Christoph, St., Coughtrie, M.W.H., Falany, C.N., Hagen, M., Landsiedel, R., Pabel, U., Phillips, D.H., Seidel, A., Yamazoe, Y.
Sulfotransferase-mediated activation of mutagens, studied using heterologous expression systems.
Chem.-biol. Interact., 109 (1998) 195-219

Nr. 111

Sundberg, K., Johansson, A.S., Stenberg, G., Widersten, M., Seidel, A., Mannervik, B. and Jernström, B.
Differences in the catalytic efficiencies of allelic variants of glutathione transferase P1-1 towards carcinogenic diol epoxides of polycyclic aromatic hydrocarbons.
Carcinogenesis, 19 (1998) 433-436

1997

Nr. 110

Melendez-Colon, V.J., Smith, C.A., Seidel, A., Luch, A., Platt, K.L., and Baird, W.M.
Formation of stable adducts and absence of depurinating adducts upon reaction of the diol epoxides of the potent carcinogen dibenzo[a,l]pyrene with DNA in solution and in cells.
Proc. Natl. Acad. Sci. U.S.A., 94 (1997) 13542-13547

Nr. 109

Giles, A.S., Seidel, A., and Phillips, D.H.
Covalent DNA adducts formed by benzo[c]-chrysene in mouse epidermis and by benzo[c]chrysene fjord-region diol-epoxides reacted with DNA and polynucleotides.
Chem. Res. Toxicol., 10 (1997) 1275-1284

Nr. 108

Sundberg, K., Widersten, M., Seidel, A., Mannervik, B., and Jernström, B.
Glutathione conjugation of bay- and fjord-region diol epoxides of polycyclic aromatic hydrocarbons by glutathione transferases M1b-1b and P1-1.
Chem. Res. Toxicol., 10 (1997) 1221-1227

Nr. 107

Luch, A., Seidel, A., Glatt, H.R., and Platt, K.L.
Metabolic activation of the (+)-(S,S)- and (-)-(R,R)-enantiomers of trans-11,12-dihydroxy-11,12-dihydrodi-benzo[a,l]pyrene: stereo-selectivity, DNA adduct formation, and mutagenicity in Chinese hamster V79 cells.
Chem. Res. Toxicol., 10 (1997) 1161-1170

Nr. 106

Funk, M., Pontén, I., Seidel, A., and Jernström, B.
Critical parameters for adduct formation of the four stereoisomeric benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxides with oligo­nucleotides.
Bioconjugate Chem., 8 (1997) 310-317

Nr. 105

Steinberg, P., Heck, R., Frank, H., Odenthal, M., Dienes, H.-P., and Seidel, A.
The role of the Ha-ras gene in the malignant transformation of rat liver oval cells.
Inter. J. Cancer., 71 (1997) 680-685

Nr. 104

Ralston, S., Coffing, S., Seidel, A., Luch, A., Platt, K.L., and Baird, W.M.
Stereoselective activation of dibenzo[a,l]pyrene and its trans-11,12-dihydrodiol to fjord region 11,12-diol 13,14-epoxides in a human mammary carcinoma MCF-7 cell-mediated V79 cell mutation assay.
Chem. Res. Toxicol., 10 (1997) 687-693

Nr. 103

Jankowiak, R., Ariese, F., Zamzow, D., Luch, A., Kroth, H., Seidel, A., and Small, G.J.
Conformational studies of stereoisomeric tetraols derived from syn- and anti-dibenzo[a,l]pyrene diolepoxides.
Chem. Res. Toxicol., 10 (1997) 677-686

Nr. 102

Hanelt, S., Helbig, R., Hartmann, A., Lang, M., Seidel, A., and Speit, G.
A comparative investigation of DNA adducts, DNA strand breaks and gene mutations induced by benzo[a]pyrene and (±)-benzo[a]pyrene-7,8-diol-9,10-epoxide in cultured human cells.
Mutagenesis, 390 (1997) 179-188

Nr. 101

Müller, F., Arand, A., Frank, H., Seidel, A., Hinz, W., Winkler, L., Hänel, K., Blée, E., Beetham, J.K., Hammock, B.D., and Oesch, F.
Visualization of the covalent intermediate formed between microsomal epoxide hydrolase and 9,10-epoxystearic acid during enzymatic epoxide hydrolysis.
Eur. J. Biochem., 245 (1997) 490-496

Nr. 100

Turchi, G., Glatt, H.R., Seidel, A., Puliti, A., and Sbrana, I.
Structure-activity relationship in the induction of chromosomal aberrations and spindle disturbances in Chinese hamster epithelial liver cells by regioisomeric phenanthrene quinones.
Cell Biol. Toxicol., 13 (1997) 155-165

1996

Nr. 99

Kroth, H., Oesch, F., and Seidel, A.
Synthesis of stereoisomeric N6-deoxy-adenosine adducts of syn- and anti-dihydrodiol epoxides of benzo[a]pyrene and their incorporation into 18-mer DNA sequences from human Ha-ras protooncogene.
Polycycl. Arom. Compds., 11 (1996) 349-356

Nr. 98

Landsiedel, R., Engst, W., Scholtyssek, M., Seidel, A., Glatt, H.R.
Nucleophilic displacement reactions at the benzylic position of the sulfuric acid ester 1-sulfooxymethylpyrene: Potential influence on in vivo reactivity.
Polycycl. Arom. Compds., 11 (1996) 341-348

Nr. 97

Buchwald-Goebel, S., Oesch, F., and Seidel, A.
A tandem photochemical approach for the synthesis of biologically important metabolites of benzo[b]fluoranthene.
Polycycl. Arom. Compds., 11 (1996) 325-332

Nr. 96

Steinberg, P., Oesch, F., and Seidel, A.
The stereoisomeric fjord-region benzo[c]-phenanthrene-3,4-dihydrodiol 1,2-oxides malignantly transform rat liver epithelial cells.
Polycycl. Arom. Compds., 10 (1996) 275-282

Nr. 95

Baird, W.M., Ralston, S., Luch, A., Platt, K.L., and Seidel, A.
Stereoselective metabolic activation of dibenzo[a,l]pyrene in the human mammary carcinoma cell line MCF-7 results in formation of (-)-anti and (+)-syn-11,12-diol-13,14-epoxide-deoxyadenosine adducts in DNA.
Polycycl. Arom. Compds., 10 (1996) 235-242

Nr. 94

Pfau, W., Seidel, A., Phillips, D.H., Oesch, F., and Grover, P.L.
32P-postlabelling/ HPLC analysis of DNA adducts formed from chrysene and its metabolites.
Polycycl. Arom. Compds., 10 (1996) 219-226

Nr. 93

Seidel, A., Sun, Z., Kroth, H., Steinbrecher, T., Oesch, F., and Friedberg, T.
DNA-polymerase action on oligonucleotide templates from human Ha-ras proto-oncogenes containing N6-deoxyadenosine adducts derived from trans addition of (+)- and (-)-anti-benzo[c]­phenanthrene-3,4-dihydrodiol 1,2-oxide at Codon 61.
Polycycl. Arom. Compds., 10 (1996) 161-170

Nr. 92

Frank, H., Luch, A., Oesch, F., and Seidel, A.
4-[4(Dimethylamino)phenylazo]-benzoate, a new red-shifted chromophore for use in the exciton chirality method: Assignment of absolute configuration to fjord-region metabolites of dibenzo[a,l]pyrene.
Polycycl. Arom. Compds., 10 (1996) 109-116

Nr. 91

Luch, A., Seidel, A., Glatt, H.R., Oesch, F., and Platt, K.L.
Correlation of the extent of fjord-region oxidation with DNA binding and mutagenicity of the enantiomeric 11,12-dihydrodiols of dibenzo[a,l]pyrene in vitro.
Polycycl. Arom. Compds., 10 (1996) 101-108

Nr. 90

Ponten, I., Seidel, A., Gräslund, A., and Jernström, B.
Studies on oligonucleotides modified with the enantiomers of the anti- and syn-diastereomers of benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide.
Polycycl. Arom. Compds., 10 (1996) 93-100

Nr. 89

Degenhardt, C., Bors, W., Seidel, A., Frank, H., and Platt, K.L.
Metabolic activation of anthanthrene: Significance of stable radicals derived from its key metabolite 3-hydroxy-anthanthrene.
Polycycl. Arom. Compds., 10 (1996) 85-92

Nr. 88

Reindl, M., Seidel, A., Frank, H. and Platt, K.L.
Detection of reactive quinones in the metabolism of polycyclic aromatic hydrocarbons by the formation of their glutathione conjugates.
Polycycl. Arom. Compds., 10 (1996) 77-84

Nr. 87

Jernström, B., Mannervik, B., Funk, M., and Seidel, A.
Glutathione conjugation of diol epoxides of polycyclic aromatic hydrocarbons catalyzed by human glutathione transferase A1-1.
Polycycl. Arom. Compds., 10 (1996) 51-57

Nr. 86

Jacob, J., Doehmer, J., Grimmer, G., Soballa, V., Raab, G., Seidel, A., and Greim, H.
Metabolism of phenanthrene, benz[a]anthracene, benzo[a]pyrene and benzo[c]­phenanthrene by eight cDNA-expressed human and rat cytochromes.
Polycycl. Arom. Compds., 10 (1996) 1-9

Nr. 85

Speit, G., Hanelt, S., Helbig, R., Seidel, A. and Hartmann, A.
Detection of DNA effects in human cells with the comet assay and their relevance for mutagenesis.
Toxicol. Lett., 88 (1996) 91-98

Nr. 84

Glatt, H.R., Christoph, S., Czich, A., Pauly, K., Schwierzok, A., Seidel, A., Coughtrie, M.W.H., Doehmer, J., Falany, C.N., Phillips, D.H., Yamazoe, Y., and Bartsch, I.
Rat and human sulfotransferases expressed in Ames's Salmonella typhimurium strains and Chinese hamster V79 cells for the activation of mutagens.
Control Mechanisms of Carcinogenesis (ed's J.G. Hengstler and F. Oesch), Publishing House of the Editors: J.G. Hengstler & F. Oesch (1996) p. 98-115

Nr. 83

Jernström, B., Funk, M., Frank, H., Mannervik, B., and Seidel, A.
Glutathione tranferase A1-1 catalyzed conjugation of bay- and fjord-region diol epoxides of polycyclic aromatic hydrocarbons with glutathione.
Carcinogenesis, 17 (1996) 1491-1498

Nr. 82

Giles, A.S., Seidel, A., and Phillips, D.H.
Covalent DNA adducts formed in mouse epidermis by benzo[g]chrysene.
Carcinogenesis, 17 (1996) 1331-1336

Nr. 81

Windsor, S.A., Tinker, M.H., Osborne, M.R. and Seidel, A.
Studies of the binding of diol-epoxide metabolites of polycyclic aromatic hydrocarbons to DNA using electro-fluorescence polarization spectroscopy.
Carcinogenesis, 17 (1996) 605-608

Nr. 80

Jacob, J., Raab, G., Soballa, V., Holtkamp, D., Schmalix, W., Grimmer, G., Greim, H. Doehmer, J., and Seidel, A.
Cytochrome P450-mediated activation of phenanthrene in genetically engineered V79 Chinese hamster cells.
Environ. Toxicol. Pharmacol., 1 (1996) 1-11

Nr. 79

Pontén, I., Seidel, A., Gräslund, A., and Jernström, B.
Characterization of adducts derived from the syn-diastereomer of benzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide and the oligo­nucleotide 5'-d(CCTATAGATATCC).
Chem. Res. Toxicol., 9 (1996) 188-196

1995

Nr. 78

Glatt, H., Bartsch I., Czich A., Seidel A. and Falany C.N.
Salmonella strains and mammalian cells genetically engineered for expression of sulfotransferases.
Toxicol. Lett., 82-3 (1995) 829-834

Nr. 77

Ralston, S., Seidel, A., Platt, K.L., Luch, A., and Baird, W.M.
Stereochemical selectivity of activation of dibenzo[a,l]pyrene to (-)-anti- and (+)-syn-DB[a,l]P-11,12-diol-13,14-epoxide which bind extensively to deoxyadenosine residues of DNA in the human mammary carcinoma cell line MCF-7.
Carcinogenesis, 16 (1995) 2899-2907

Nr. 76

Sbrana, I., Puliti, A., Seidel, A., Glatt, H.R., and Turchi, G.
Induction of chromosomal aberrations and spindle disturbances in Chinese hamster epithelial liver cells in culture by pyrene and benzo[a]pyrene quinones.
Mutagenesis, 10 (1995) 505-512

Nr. 75

Du, M.Q., Seidel, A., and Phillips, D.H.
Activating mutations in human c-Ha-ras-1 protooncogene induced by the stereoisomeric fjord-region benzo[c]chrysene-9,10-diol 13,14-epoxides.
Mol. Carcinogen., 14 (1995) 160-169

Nr. 74

Seidel, A., Oesch, F., and Steinberg, P.
Malignant transformation of the liver tumor precursor cell line OC/CDE 22 by the four stereoisomeric fjord-region 3,4-dihydrodiol 1,2-epoxides of benzo[c]phenanthrene.
Carcinogenesis, 16 (1995) 2111-2115

Nr. 73

Goeptar, A.R., te Koppele, J.M., Glatt, H.R., Groot, E.J., Seidel, A., Barrenscheen, M., Wölfel, C., Doehmer, J., Vermeulen, N.P.E.
The cytotoxicity of mitomycin C and adriamycin in genetically engeneered V79 cell lines and freshly isolated hepatocytes.
Chem.-Biol. Interact., 97 (1995) 149-168

Nr. 72

Gschaidmaier, H., Seidel, A., Burchell, B. and Bock, K.W.
Formation of mono- and diglucuronides and of other glycosides of benzo[a]pyrene-3,6-quinol by V79 cell-expressed human phenol UDP-glucuronsyltransferase of the UGT1 complex (UGT1.6 and UGT1.07).
Biochem. Pharmacol., 49 (1995) 1601-1606

Nr. 71

Funk, M., Gath, I., Seidel, A., Oesch, F., and Platt, K.L.
Conjugation of anti-dihydrodiol epoxides of benzo[a]pyrene, chrysene, benzo[c]phenanthrene and dibenz[a,h]anthracene with glutathione catalysed by cytosol and by the mu-class glutathione transferase HTP II from rat liver.
Chem. Biol. Interact., 95 (1995) 189-201

Nr. 70

Giles, A., Seidel, A., and Phillips, D.H.
Reactivities towards DNA of the fjord-region diol-epoxides of benzo[g]chrysene and benzo[c]phenanthrene as revealed by 32P-postlabeling.
Chem. Res. Toxicol., 8 (1995) 591 - 599

Nr. 69

Doehmer, J, Holtkamp, D, Soballa, V., Raab, G., Schmalix, W., Seidel, A., Greim, H. and Jacob, J.
Cytochrome P450 mediated reactions studied in genetically engineered V79 Chinese hamster cells.
Pharmacogenetics, 5 (1995) S91 - S96

1994

Nr. 68

Glatt, H.R., Pauly, K., Frank, H., Seidel, A., Oesch, F., Harvey, R.G., and Werle-Scheider, G.
Substance-dependent sex differences in the activation of benzylic alcohols to mutagens by hepatic sulfotransferases of the rat.
Carcinogenesis, 15 (1994) 2605-2611

Nr. 67

Luch, A., Glatt, H.R., Platt, K.L., Oesch, F., and Seidel, A.
Synthesis and mutagenicity of the diastereomeric fjord-region 11,12-dihydrodiol 13,14-epoxides of dibenzo[a,l]pyrene.
Carcinogenesis, 15 (1994) 2507-2516

Nr. 66

Glatt, H.R., Pauly, K., Piée-Staffa, Seidel, A., Hornhardt, S., and Czich, A.
Activation of promutagens by endogenous and heterologous sulfotransferases expressed in continous cell cultures.
Toxicology Lett., 72 (1994) 13-21

Nr. 65

Glatt, H.R., Werle-Schneider, G., Enders, N., Monnerjahn, S., Pudil, J., Czich, A., Seidel, A., and Schwarz, M.
1-Hydroxymethylpyrene and its sulfuric acid ester: toxicological effects in vitro and in vivo, and metabolic aspects.
Chem.-Biol. Interact., 92 (1994) 305-319

Nr. 64

Glatt, H.R., Werle-Schneider, G., Seidel, A., and Schwarz, M.
Initiation and promotion of enzyme-altered foci in rat liver by 1-hydroxymethylpyrene.
Polycycl. Arom. Compds., 7 (1994) 153-160

Nr. 63

Glatt, H.R., Pudil, J., Seidel, A., and Czich, A.
Stable expression of heterologous sulfo-transferase in V79 cells: activation of primary and secondary benzylic alcohols.
Polycycl. Arom. Compds., 7 (1994) 67-74

Nr. 62

Ralston, S.L., Lau, H.H.S., Seidel, A., Luch, A., Platt, K.L., and Baird, W.M.
Identification of dibenzo[a,l]pyrene-DNA adducts formed in cells in culture and in mouse skin.
Polycycl. Arom. Compds., 6 (1994) 199-206

Nr. 61

Seidel, A., Luch, A., Platt, K.L., Oesch, F., and Glatt, H.R.
Activated fjord-region metabolites of dibenzo[a,l]pyrene: Synthesis and mutagenic activities of the diastereomeric syn- and anti-11,12-dihydrodiol 13,14-epoxides.
Polycycl. Arom. Compds., 6 (1994) 191-198

Nr. 60

Glatt, H.R., Seidel, A., Oesch, F., and Gumbsch, A.
Fjord-region diol-epoxides of benzo[c]chrysene are potent inducers of micronuclei in murine bone marrow.
Mutat. Res., 309 (1994) 37-43

Nr. 59

Post, K., Seidel, A., Platt, K. L., Oesch, F., and Klein, J.
Regiospecific oxidation of dihydrodiols and reduction of quinones by rabbit liver dihydrodiol dehydrogenase.
Chem.-Biol. Interact., 90 (1994) 157-168

Nr. 58

Funk, M., Gath, I., Seidel, A., Platt, K. L., Oesch, F. and Zeller, H.D.
Different enzyme kinetics during the glutathione conjugation of the four stereoisomeric forms of the fjord-region diolepoxide of benzo[c]phenanthrene by the acidic rat liver glutathione S-transferase HTP II.
Biochem. Pharmacol., 47 (1994) 505-514

Nr. 57

Ralston, S.L., Lau, H.H.S., Seidel, A., Luch, A., Platt, K.L., and Baird, W.M.
The potent carcinogen dibenzo[a,l]pyrene is metabolically activated to fjord-region 11,12-diol 13,14-epoxides in human mammary carcinoma MCF-7 cell cultures.
Cancer Res., 54 (1994) 887 - 890

1993

Nr. 56

Schmalix, W.A., Mäser, H., Kiefer, F., Reen, R., Wiebel, F.J., Gonzalez, F., Seidel, A., Glatt, H.R., Greim, H., and Doehmer, J.
Stable expression of human cytochrome P450 1A1 cDNA in V79 Chinese hamster cells and metabolic activation of benzo[a]pyrene.
Eur. J. Pharmacol. - Environ. Toxicol. Pharmacol. Sec., 248 (1993) 251 - 261

Nr. 55

Glatt, H. R., Henschler, R., Frank, H., Seidel, A., Oesch, F., Yang, C. X., Abu-Shqara, E., and Harvey, R. G.
Sulfotransferase-mediated mutagenicity of 1-hydroxymethyl-pyrene and 4H-cyclopenta[def]chrysen-4-ol and its enhancement by chloride anions.
Carcinogenesis, 14 (1993) 599-602

Nr. 54

Steinbrecher, T., Becker, A, Stezowski, J.J., Oesch, F., and Seidel, A.
Synthesis of oligo­deoxynucleotides containing diastereomeric diol epoxide-N6-deoxy-adenosine adducts of polycyclic aromatic hydrocarbons.
Tetrahedron Lett., 34 (1993) 1773-1774

Nr. 53

Jernström, B., Funk, M., Steinbrecher, T., and Seidel, A.
Glutathione transferase catalyzed conjugation of diol epoxides derived from polycyclic aromatic hydrocarbons with glutathione.
Polycycl. Arom. Compds., 3 (1993) 213 - 219

Nr. 52

Pfau, W., Lecoq, S., Hughes, N.C., Seidel, A., Platt, K.L., Grover, P.L., and Phillips, D.H.
Formation of DNA adducts by 1-hydroxy-methylpyrene in liver cells in vivo and in vitro.
Postlabelling Methods for Detection of DNA Adducts, IARC Scientific Publication No. 124, IARC, Lyon (France) (1993) pp 233 - 242

Nr. 51

Monnerjahn, S., Seidel, A., Steinberg, P., Oesch, F., Hinz, M., Stezowski, J.J., Hewer, A., Phillips, D.H., and Glatt, H.R.
Formation of DNA adducts by 1-hydroxymethylpyrene in liver cells in vivo and in vitro.
Postlabelling Methods for Detection of DNA Adducts, IARC Scientific Publication No. 124, IARC, Lyon (France) (1993) pp 189 - 193

Nr. 50

Glatt, H. R., Pauly, K., Wölfel, C., Dogra, S., Seidel, A., Lee, H., Harvey, R.G., Oesch, F., and Doehmer, J.
Stable expression of heterologous cytochromes P450 in V79 cells: mutagenicity studies with polycyclic aromatic hydrocarbons.
Polycyclic Aromatic Compounds: Synthesis, Properties, Analytical Measurements, Occurrence and Biological Effects (P. Garrigues and M. Lamotte, eds.) Gordon and Breach Science Publishers, Yverdon (Switzerland) (1993) pp 1167 - 1174

Nr. 49

Lecoq, S., Platt, K.L., Seidel, A., Oesch, F., Phillips, D.H., and Grover, P.L.
Comparisons of the metabolic activation of dibenz[a,h]anthracene and picene using 32P-postlabelling.
Polycyclic Aromatic Compounds: Synthesis, Properties, Analytical Measurements, Occurrence and Biological Effects (P. Garrigues and M. Lamotte, eds.) Gordon and Breach Science Publishers, Yverdon (Switzerland) (1993) pp 921 - 928

Nr. 48

Enders, N., Seidel, A., Monnerjahn, S. and Glatt, H.R.
Synthesis of 11 benzylic sulfate esters and their bacterial mutagenicity in dependence of the presence of chloride, bromide and acetate anions.
Polycyclic Aromatic Compounds: Synthesis, Properties, Analytical Measurements, Occurrence and Biological Effects (P. Garrigues and M. Lamotte, eds.) (Supplement to Polycyclic Aromatic Compounds, Vol. 3), Gordon and Breach Science Publishers, Yverdon (Swit (1993) pp 887 - 894

Nr. 47

Glatt, H.R., Wameling, C., Elsberg, S., Thomas, H., Marquardt, H., Hewer, A., Phillips, D.H., Oesch, F., and Seidel, A.
"Reverse" diol-epoxides of chrysene: genotoxicity characteristics.
Polycyclic Aromatic Compounds: Synthesis, Properties, Analytical Measurements, Occurrence and Biological Effects (P. Garrigues and M. Lamotte, eds.) Gordon and Breach Science Publishers, Yverdon (Switzerland) (1993) pp 879 - 886

Nr. 46

Johannes, A., Schmoldt, A., Seidel, A., and Glatt, H.R.
Sulfate conjugation of various hydroxy-PAH by rat liver sulfotransferases.
Polycyclic Aromatic Compounds: Synthesis, Properties, Analytical Measurements, Occurrence and Biological Effects (P. Garrigues and M. Lamotte, eds.) Gordon and Breach Science Publishers, Yverdon (Switzerland) (1993) pp 703 - 710

Nr. 45

Augustin, C., Schmoldt, A., Glatt, H.R., and Seidel, A.
Various UDP-glucuronosyl-transferases involved in regiospecific conjugations of hydroxy-PAH.
Polycyclic Aromatic Compounds: Synthesis, Properties, Analytical Measurements, Occurrence and Biological Effects (P. Garrigues and M. Lamotte, eds.) Gordon and Breach Science Publishers, Yverdon (Switzerland) (1993) pp 687 - 694

Nr. 44

Steinbrecher, T., Wameling, C., Oesch, F., and Seidel, A.
Synthesis of polycyclic aromatic hydrocarbon adducts attached to the exocyclic amino group of 2'-deoxyguanosine via nucleophilic substitution.
Polycyclic Aromatic Compounds: Synthesis, Properties, Analytical Measurements, Occurrence and Biological Effects (P. Garrigues and M. Lamotte, eds.) Gordon and Breach Science Publishers, Yverdon (Switzerland) (1993) pp 223 - 230

Nr. 43

Funk, M., Frank, H., Platt, K. L., Oesch, F., and Seidel, A.
Synthesis and characterization of glutathione conjugates of diastereomeric bay- and fjord-region dihydrodiol epoxides.
Polycyclic Aromatic Compounds: Synthesis, Properties, Analytical Measurements, Occurrence and Biological Effects (P. Garrigues and M. Lamotte, eds.) Gordon and Breach Science Publishers, Yverdon (Switzerland) (1993) pp 207 - 214

Nr. 42

Wameling, C., Glatt, H.R., Oesch, F., and Seidel, A.
Stereospecific synthesis of the diastereomeric "reverse" dihydrodiol epoxides of chrysene and picene.
Polycyclic Aromatic Compounds: Synthesis, Properties, Analytical Measurements, Occurrence and Biological Effects (P. Garrigues andM. Lamotte, eds.) Gordon and Breach Science Publishers, Yverdon (Switzerland) (1993) pp 191 - 198

Nr. 41

Steinbrecher, T., Wameling, C., Oesch, F., and Seidel, A.
Activation of the C2 position of purine by the trifluoromethanesulfonate group: synthesis of N2-alkylated deoxyguanosines.
Angew. Chem. Int. Ed. Engl., 32 (1993) 404-406

Nr. 40

Steinbrecher, T., Wameling, C., Oesch, F., and Seidel, A.
Die Trifluormethan- sulfonatfunktion als neue Aktivierung der C-2-Position am Purin: Synthese von N2-alkylierten Deoxyguanosinen.
Angew. Chem., 105 (1993) 408-410

Nr. 39

Glatt, H.R., Wameling, C., Elsberg S., Thomas H., Marquardt H., Hewer A.,Phillips D.H., Oesch F., and Seidel, A.
Genotoxicity characteristics of prebay-region diol-epoxides of chrysene.
Carcinogenesis, 14 (1993) 11-19

1992

Nr. 38

Bock, K.W., Gschaidmeier, H., Seidel, A., S. Baird, and Burchell, B.
Mono- and diglucuronide formation of chrysene and benzo[a]pyrene phenols by 3-methylcholanthrene-inducible phenol UDP-glucuronosyltransferase (UGT1A1).
Mol. Pharmacol., 42 (1992) 613-618

Nr. 37

Jernström, B., Seidel, A., Funk, M., Oesch, F., and Mannervik, B.
Glutathione conjugation of trans-3,4-dihydroxy 1,2-epoxy 1,2,3,4-tetrahydrobenzo[c]phenanthrene isomers by human glutathione transferases.
Carcinogenesis, 13 (1992) 1549-1555

Nr. 36

Wölfel, C., Heinrich-Hirsch, B., Schulz-Schalge, T., Seidel, A., Frank, H., Ramp, U., Wächter, F., Wiebel, F. J., Gonzalez, F., Greim, H., and Doehmer, J.
Genetically engineered V79 chinese hamster cells for stable expression of human cytochrome P450IA2.
Eur. J. Pharmacol. - Environ. Toxicol. Pharmacol. Sec., 228 (1992) 95-102

Nr. 35

Klein, J., Post, K., Seidel, A., Frank, H., Oesch, F., and Platt, K.L.
Quinone reduction and redox cycling catalysezed by purified rat liver dihydrodiol/3a-hydroxysteroid dehydrogenase.
Biochem. Pharmacol., 44 (1992) 341-349

Nr. 34

Doehmer, J., Janssens, C., Dogra, S., Doehmer, C., Seidel, A., Platt, K.-L., Oesch, F., and Glatt, H.R.
Application of stable V79 derived cell lines expressing rat cytochromes P450IAI, IA2, and IIB1.
Xenobiotica, 22 (1992) 1093-1099

Nr. 33

Phillips, D.H., Hewer, A., Seidel, A., Steinbrecher, T., Schrode, R., Oesch, F., and Glatt, H.R.
Relationship between mutagenicity and DNA adduct formation in mammalian cells for fjord- and bay-region diol-epoxides of polycyclic aromatic hydrocarbons.
Chem.-Biol. Interactions, 80 (1992) 177-186

1991

Nr. 32

Klein, J., Seidel, A., Frank, H., Oesch, F., and Platt, K.L.
Regiospecific oxidation of polycyclic aromatic dihydrodiols by rat liver dihydrodiol dehydrogenase.
Chem.-Biol. Interactions, 79 (1991) 287-303

Nr. 31

Doehmer, J., Dogra, S., Janssens, C., Edigkaufer, M., Seidel, A., Glatt, H.R., Platt, K.-L., and Oesch, F.
Die gentechnologische Konstruktion von V79 Chinesischen Hamsterzellen zur stabilen Expression von Fremdstoff-metabolisierenden Enzymen und ihre Anwendung in Metabolismus- und Mutagenitäts-Studien von Pharmaka und anderen Fremdstoffen.
Alternativen zu Tierexperimenten, 8 (1991) 52 - 64

Nr. 30

Seidel, A., Bochnitschek, W., Glatt, H.R., Hodgson, R.M., Grover, P.L., and Oesch, F.
Activated Metabolites of chrysene: Synthesis of 9-Hydroxychrysene-1,2-diol and the corresponding bay-region syn- and anti-triol-epoxides.
Polynuclear Aromatic Hydrocarbons: Measurements, Means and Metabolism (ed's. M. Cooke, K. Loening and J. Meritt), Battelle Press, Columbus, OH (1991) pp 801 - 817

Nr. 29

Ludewig, G., Dogra, S., Seidel, A., Setiabudi, F., Oesch, F., and Glatt, H.R.
Quinones derived from polycyclic aromatic hydrocarbons: Induction of diverse mutagenic and genotoxic effects in mammalian cells.
Polynuclear Aromatic Hydrocarbons: Measurements, Means and Metabolism (ed's. M. Cooke, K. Loening and J. Meritt), Battelle Press, Columbus, OH (1991) pp 545 - 556

Nr. 28

Glatt, H. R., Seidel, A., Schrode, R., Ribeiro, O., Kirkby, C. A., Hirom, P. C., and Oesch, F.
3-Hydroxybenzo[a]pyrene-7,8-dihydrodiol compared with benzo[a]­pyrene-7,8-dihydrodiol and 3-hydroxybenzo[a]pyrene with regard to muta-genicity.
Polynuclear Aromatic Hydrocarbons: Measurements, Means and Metabolism (ed's. M. Cooke, K. Loening and J. Meritt), Battelle Press, Columbus, OH (1991) pp 357 - 368

Nr. 27

Glatt, H.R., Piée A., Pauly K., Steinbrecher, T., Schrode R., Oesch, F. and Seidel, A.
Fjord- and bay-region diol-epoxides investigated on stability, SOS induction in Escherichia coli, and mutagenicity in Salmonella typhimurium and mammalian cells.
Cancer Res, 51 (1991) 1659-1667

1990

Nr. 26

Hradec, J., Seidel, A., Platt, K.L., Glatt, H.R., Oesch, F., and Koblyakov, V.
The Initiator tRNA acceptance assay as a short-term test for carcinogens. 6. Results with 78 polycyclic aromatic compounds.
Carcinogenesis, 11 (1990) 1921-1926

Nr. 25

Steinberg, P., Schlemper, B., Molitor, E., Platt, K.L., Seidel, A., and Oesch, F.
Rat liver Kupffer and endothelial cell-mediated mutagenicity of polycyclic aromatic hydrocarbons and aflatoxin B1.
Environ. Health Perspect., 88 (1990) 71-76

Nr. 24

Doehmer, J., Seidel, A., Oesch, F., and Glatt, H.R.
Genetically-engineered V79 chinese hamster cells metabolically activate the cytostatic drugs cyclophosphamide and ifosfamide.
Environ. Health Perspect., 88 (1990) 63-65

Nr. 23

Glatt, H.R., Henschler, R., Phillips, D. H., Blake, J. W., Steinberg, P., Seidel, A., and Oesch, F.
Sulfotransferase-mediated chlorination of 1-hydroxymethylpyrene to a mutagen capable of penetrating into indicator cells.
Environ. Health Perspect., 88 (1990) 43-48

Nr. 22

Masento, M.S., Taylor, G.W., Watson, D., Seidel, A., Bochnitschek, W., Oesch, F., and Grover, P.L.
Metabolism of 3-hydroxychrysene by rat liver microsomal preparations.
Chem.-Biol. Interactions, 74 (1990) 163-178

Nr. 21

Dogra, S., Doehmer, J., Glatt, H.R., Siegert, P., Friedberg, T., Seidel, A., and Oesch, F.
Stable expression of rat P450IA1 cDNA in V79 Chinese hamster cells and their use in mutagenicity testing.
Mol. Pharmacol., 37 (1990) 608-613

Nr. 20

Seidel, A., Glatt, H.R., Oesch, F., and Garrigues, P.
2,9-Dimethylpicene: Synthesis, mutagenic activity, and identification in natural samples.
Polycycl. Arom. Compds., 1 (1990) 3-14

1989

Nr. 19

Knepper T., Lenhardt, S., Przybylski, M., Bosk, C., Platt, K.L., Seidel, A., and Oesch, F.
Identification and structural characterization of mono- and bis- glutathionyl conjugates from polyaromatic quinone metabolites.
Advances in Mass Spectrometry (ed. P. Longevialle), Vol. 11B (Proceedings of the 11th International Mass Spectrometry Conference held at Bordeaux 29. August - 2. September 1988), Heydon & Son, London (1989) pp 1398 - 1399

Nr. 18

Doehmer, J., Dogra, S., Edigkaufer, M., Molitor, E., Siegert, P., Friedberg, T., Glatt, H.R., Platt, K.L., Seidel, A., Thomas, H., and Oesch, F.
Introduction of cytochrome P-450 genes into V79 Chinese hamster cells to generate new mutagenicity test systems.
Arch. Toxicol., Suppl., 13 (1989) 164 - 168

1988

Nr. 17

Glatt, H.R., Hirom, P.C., Kirkby, C.A., Ribeiro, O., Seidel, A., and Oesch, F.
Complex metabolic activation pathways of polycyclic aromatic hydrocarbons: 3-Hydroxy-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene as a proximate mutagen of 3-hydroxybenzo[a]­pyrene.
Chemical Carcinogenesis (eds. F. Feo, P. Pani, A. Columbano, and R. Garcea), Plenum Publishing Corporation, New York (1988) pp 37 - 44

Nr. 16

Platt, K.L., Petrovic, P., Seidel, A., Beermann, D., and Oesch, F.
Microsomal metabolism of picene.
Chem.-Biol. Interactions, 66 (1988) 157-175

Nr. 15

Heidmann, M., Fonrobert, P., Przybylski, M., Platt, K.L., Seidel, A., and Oesch, F.
Conjugation reactions of polyaromatic quinones to mono- and bisglutathionyl adducts: Direct analysis by fast atom bombardment mass spectrometry.
Biomed. Environm. Mass Spectrometry, 15 (1988) 329-332

1987

Nr. 14

Hodgson, R.M., Seidel, A., Bochnitschek, W., Glatt, H.R., Oesch, F., and Grover, P. L.
Formation of glutathion conjugates from chrysene diol- and triol-epoxides: Evidence for the further metabolism of the “bay-region” diol-epoxide of chrysene to a triol-epoxide. In: Glutathione S -Transferases and Carcinogenesis (eds. T.J. Mantle, C.B. Pickett, and J.D. Hayes)
Taylor & Francis, London (1987) pp 239 - 243

Nr. 13

Glatt, H.R., Seidel, A., Ribeiro, O., Kirkby, C., Hirom, P., and Oesch, F.
Metabolic activation to a mutagen of 3-hydroxy-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene, a secondary metabolite of benzo[a]pyrene.
Carcinogenesis, 8 (1987) 1621-1627

1986

Nr. 12

Glatt, H.R., Henschler, R., Klein, J., Ludewig, G., Martiné, U., Pauly, K., Piée, A., Platt, K.L., Seidel, A., Setiabudi, S. and Utesch, D.
Multiple activation pathways of both benzene and polycyclic aromatic hydrocarbons leading to products with varying cytotoxic and genotoxic characteristics. In: Primary Changes and Control Factors in Carcinogenesis (eds. T. Friedberg, and F. Oesch)
Deutscher Fach-schriften-Verlag, Wiesbaden (Germany) (1986) pp 55 - 59

Nr. 11

Hodgson, R. M., Weston, A., Seidel, A., Bochnitschek, W., Glatt, H. R., Oesch, F., and Grover, P. L.
Metabolism of chrysene to triols and a triol-epoxide in mouse skin and rat liver preparations.
Polynuclear Aromatic Hydrocarbons: Chemistry, Characterization and Carcinogenesis (eds. M. Cooke, and A. J. Dennis), Battelle Press, Columbus, OH (1986) pp. 387 - 399

Nr. 10

Glatt, H. R., Seidel, A., Bochnitschek, W., Marquardt, H., Marquardt, H., Hodgson, R. M., Grover, P. L., and Oesch, F.
Mutagenicity in bacterial and mammalian cells of diol-epoxides, triol-epoxides and other metabolites of chrysene.
Polynuclear Aromatic Hydrocarbons: Chemistry, Characterization and Carcinogenesis (eds. M. Cooke , and A. J. Dennis), Battelle Press, Columbus, OH (1986) pp. 343 - 358

Nr. 9

Hodgson, R.M., Seidel, A., Bochnitschek, W., Glatt, H.R., Oesch, F., and Grover, P.L.
Metabolism of the bay-region diol-epoxide of chrysene to a triol-epoxide and the enzyme-catalysed conjugation of these epoxides with glutathione.
Carcinogenesis, 7 (1986) 2095-2098

Nr. 8

Phillips, D.H., Glatt, H.R., Seidel, A., Bochnitschek, W., Oesch, F., and Grover, P.L.
Mutagenic potential and DNA adducts formed by diol-epoxides, triol-epoxides and K-region epoxides of chrysene in mammalian cells.
Carcinogenesis, 7 (1986) 1739-1743

Nr. 7

Glatt, H.R., Seidel, A., Bochnitschek, W., Marquardt, H., Marquardt, H., Hodgson, R.M., Grover, P.L., and Oesch, F.
Mutagenic and cell-transforming activities of triol-epoxides as compared to other chrysene metabolites.
Cancer Res., 46 (1986) 4556-4565

Nr. 6

Wermuth, B., Platt, K. L., Seidel, A., and Oesch, F.
Carbonyl reductase provides the enzymatic basis of quinone detoxication in man. Biochem.
Pharmacol., 35 (1986) 1277-1282

1985

Nr. 5

Hodgson, R. M., Seidel, A., Bochnitschek, W., Glatt, H.R., Oesch, F., and Grover, P.L.
The formation of 9-hydroxychrysene-1,2-diol as an intermediate in the metabolic activation of chrysene.
Carcinogenesis, 6 (1985) 135-139

Nr. 4

Bochnitschek, W., Seidel, A., Kunz, H., and Oesch, F.
Reactive metabolites of carcinogenic polycyclic hydrocarbons: Synthesis and trapping reaction of 9-hydroxybenzo[a]pyrene 4,5-oxide
Angew. Chem. Int. Ed. Engl., 24 (1985) 699-700

Nr. 3

Bochnitschek, W., Seidel, A., Kunz, H., and Oesch, F.
Reaktive Metabolite cancerogener polycyclischer Kohlenwasserstoffe: Synthese und Abfangreaktion von 9-Hydroxy-benzo[a]pyren-4,5-oxid
, 97 (1985) 703-704

1984

Nr. 2

Oesch, F., Glatt, H. R., Vogel, K., Seidel, A., Petrovic, P., and Platt, K. L.
Dihydrodiol dehydrogenase: A new level of control by both sequestration of proximate and inactivation of ultimate carcinogens.
Biochemical Basis of Chemical Carcinogenesis (eds. H. Greim, R. Jung, M. Kramer, H. Marquardt, and F. Oesch) Raven Press, New York, pp. 23 - 31 (1984)

Nr. 1

Beermann, D., Petrovic, P., Seidel, A., and Oesch, F.
A facile microsynthesis of 14C-labelled picene.
J. Labelled Compds. Radiopharm., 21 (1984) 781-787